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Jackelline Rodrigues Alvares Orlando Cesar Mantese Alan de Paula Paula Carolina Bejo Wolkers Viviene Vieira Prado Almeida Samanta Cristine Grassi Almeida Maria Luiza Leopoldo Silva Guerra Maria Cristina de Cunto Brandileone 《The Brazilian journal of infectious diseases》2011,15(1):22-27
ObjectivesTo determine the prevalence of pneumococcal serotypes and antimicrobial susceptibility in patients with meningitis, and to evaluate the implications for vaccine coverage.MethodsPneumococcal strains obtained from normally sterile fluids from patients admitted with meningitis were isolated at the Hospital de Clínicas of the Universidade Federal de Uberlândia, Minas Gerais State, and sent to the Instituto Adolfo Lutz, city of São Paulo, São Paulo State, for further identification, serotyping, and antimicrobial susceptibility determination.ResultsFrom April 1999 to April 2009, 338 pneumococcal strains were isolated, and 72 obtained from patients with meningitis, were analyzed. Patients’ ages varied from one month to 82.2 years (mean of 18.4 ± 22.9 years; median of 5.2 years) and 46 (63.9%) patients were male. Strains were isolated from cerebrospinal fluid [66 occasions (91.7%)] and blood [6 occasions (8.3%)]. The most commonly identified serotypes were 14, 19F, 3, 7F, 6A, 6B, 10A, 18C, 23F, 5, and 34. Of the 20 [27.8%] oxacillin-resistant strains, 17 [23.6%] were resistant to penicillin and nine [12.5%] to ceftriaxone, both resistance patterns being more common in children aged two years or less and during the 2005–2009 period.ConclusionsResistance to penicillin and ceftriaxone was detected in 23.6% and 12.5% of the strains, respectively, and predominated in children aged two years or less and during the 2005–2009 period. There were 24 different serotypes of pneumococcus and 79.8% of the serotypes were represented in the 7-valent conjugated vaccine [PVC7]. 相似文献
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da Fonseca LM da Luz MM Lacerda-Filho A Cabral MM da Silva RG 《International journal of colorectal disease》2012,27(2):249-255
Purpose
Although colorectal cancer is typical in the older population, tumor onset before age 40 is not infrequent. However, the behavior, characteristics, and prognosis of this disease in young patients are unclear when compared to the older population. It is believed that young patients have a poor prognosis. We hypothesized that young patients have a poor prognosis because they have advanced-stage cancer with more aggressive pathologic features. 相似文献8.
Summary
This paper presents a multi-method research project to develop a conceptual framework for measuring outcomes in studies of osteoporotic kyphosis. The research involved literature research and qualitative interviews among clinicians who treat patients with kyphosis and among patients with the condition.Introduction
Kyphosis due to at least one vertebral compression fracture is prevalent among osteoporotic patients, resulting in well-documented symptoms and impact on functioning and well-being. A three-part study led to development of a conceptual measurement framework for comprehensive assessment of symptoms, impact, and treatment benefit for kyphosis.Methods
A literature-based disease model (DM) was developed and tested with physicians (n?=?10) and patients (n?=?10), and FDA guidelines were used to develop a final disease model and a conceptual framework.Results
The DM included signs, symptoms, causes/triggers, exacerbations, and functional status associated with kyphosis. The DM was largely confirmed, but physicians and patients added several concepts related to impact on functioning, and some concepts were not confirmed and removed from the DM.Conclusions
This study confirms the need for more comprehensive assessment of health outcomes in kyphosis, as most current studies omit key concepts. 相似文献9.
Reynolds Jess E. Whitehouse Andrew J. O. Alvares Gail A. Waddington Hannah Macaskill Ella Licari Melissa K. 《Journal of autism and developmental disorders》2022,52(11):4739-4749
Journal of Autism and Developmental Disorders - This study aimed to explore the rates of motor difficulties in children from the Australian Autism Biobank, and how early motor concerns impacted on... 相似文献
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The role of lymph node revealing solution on the improvement of lymph node harvest in colorectal cancer specimens
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