全文获取类型
收费全文 | 88篇 |
免费 | 4篇 |
专业分类
耳鼻咽喉 | 1篇 |
基础医学 | 20篇 |
口腔科学 | 3篇 |
临床医学 | 5篇 |
内科学 | 6篇 |
神经病学 | 17篇 |
特种医学 | 7篇 |
外科学 | 17篇 |
预防医学 | 3篇 |
眼科学 | 1篇 |
药学 | 4篇 |
肿瘤学 | 8篇 |
出版年
2023年 | 2篇 |
2020年 | 4篇 |
2019年 | 2篇 |
2018年 | 2篇 |
2017年 | 2篇 |
2016年 | 6篇 |
2015年 | 4篇 |
2014年 | 7篇 |
2013年 | 3篇 |
2012年 | 7篇 |
2011年 | 11篇 |
2010年 | 3篇 |
2008年 | 3篇 |
2007年 | 3篇 |
2006年 | 1篇 |
2005年 | 4篇 |
2004年 | 2篇 |
2003年 | 3篇 |
2002年 | 2篇 |
2001年 | 4篇 |
1999年 | 3篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1996年 | 2篇 |
1995年 | 1篇 |
1993年 | 1篇 |
1989年 | 1篇 |
1985年 | 1篇 |
1984年 | 2篇 |
1976年 | 2篇 |
1973年 | 1篇 |
1970年 | 1篇 |
排序方式: 共有92条查询结果,搜索用时 15 毫秒
1.
2.
E.O.de Souza V. Tricoli C. Bueno Junior M.G. Pereira P.C. Brum E.M. Oliveira H. Roschel M.S. Aoki C. Urginowitsch 《Brazilian journal of medical and biological research》2013,46(4):343-347
The activation of competing intracellular pathways has been proposed to explain the
reduced training adaptations after concurrent strength and endurance exercises (CE).
The present study investigated the acute effects of CE, strength exercises (SE), and
endurance exercises (EE) on phosphorylated/total ratios of selected AMPK and
Akt/mTOR/p70S6K1 pathway proteins in rats. Six animals per exercise
group were killed immediately (0 h) and 2 h after each exercise mode. In addition, 6
animals in a non-exercised condition (NE) were killed on the same day and under the
same conditions. The levels of AMPK, phospho-Thr172AMPK (p-AMPK), Akt,
phospho-Ser473Akt (p-Akt), p70S6K1,
phospho-Thr389-p70S6K1 (p-p70S6K1), mTOR,
phospho-Ser2448mTOR (p-mTOR), and phospho-Thr1462-TSC2
(p-TSC2) expression were evaluated by immunoblotting in total plantaris muscle
extracts. The only significant difference detected was an increase (i.e., 87%) in Akt
phosphorylated/total ratio in the CE group 2 h after exercise compared to the NE
group (P = 0.002). There were no changes in AMPK, TSC2, mTOR, or p70S6K1
ratios when the exercise modes were compared to the NE condition (P ≥ 0.05). In
conclusion, our data suggest that low-intensity and low-volume CE might not blunt the
training-induced adaptations, since it did not activate competing intracellular
pathways in an acute bout of strength and endurance exercises in rat skeletal
muscle. 相似文献
3.
Specific surface area is a key parameter determining the rates of thermochemical redox reactions in metal oxides. We have experimentally investigated the effect of specific surface area on syngas production of pure ceria powders under two experiments such as a heating experiment without syngas production and an isothermal thermochemical redox cycling experiment using carbon dioxide splitting and methane partial oxidation. The specific surface area of ceria powders decreased relatively slowly during 50 hours of ceria powder heating without syngas production due to a combination of oriented attachment and grain-boundary diffusion. When cycled thermochemically, the specific surface area of ceria powders rapidly decreased only in the initial 10 minutes of reduction in the 1st cycle due to evaporation and condensation. A significant decrease of specific surface area during the initial stage of thermochemical ceria powder cycling is unavoidable even if temperatures as low as T = 1173 K are used in the reduction reaction coupled to methane partial oxidation.Specific surface area is a key parameter determining the rates of thermochemical redox reactions in metal oxides. 相似文献
4.
5.
6.
Irineu Loturco Carlos Ugrinowitsch Hamilton Roschel Valmor Tricoli Juan José González-Badillo 《Journal of Sports Science and Medicine》2013,12(1):109-115
The purpose of this study was to test if substituting a regular maximum strength-oriented training regimen by a power-oriented one at the optimal power load in the first phase of a traditional periodization produces similar performance improvements later on into the training period. Forty five soldiers of the Brazilian brigade of special operations with at least one year of army training experience were divided into a control group (CG - n = 15, 20.18 ± 0.72 yrs, 1.74 ± 0.06 m, 66.7 ± 9.8 kg, and 1RM/weight ratio = 1.14 ± 0.12), a traditional periodization group (TG - n = 15, 20.11 ± 0.7 yrs, 1.72 ± 0.045 m, 63.1 ± 3.6 kg, and 1RM/weight ratio = 1.21 ± 0.16); and a maximum-power group (MPG - n = 15, 20.5 ± 0.6 yrs, 1.73 ± 0.049m, 67.3 ± 9.8 kg, 1RM/weight ratio = 1.20 ± 0.14). Maximum strength (26.2% and 24.6%), CMJ height (30.8% and 39.1%) and sprint speed (11.6% and 14.5%) increased significantly (p < 0.05) and similarly for the MPG and TG, respectively, from pre- to post-assessments. Our data suggests that a power training regimen may be used in the initial phase of the training cycle without impairing performance later on into the training period.
Key points
- Training at the optimal power zone during two mesocycles of a traditional periodization did not hamper strength, speed and power performance improvements.
- Additional research is required in order to find out if longer periods of training at optimal power zone are capable of producing similar performance improvements to traditional strength training regimen.
7.
Carla Silva-Batista Hélcio Kanegusuku Hamilton Roschel Eduardo O. Souza Telma F. Cunha Gilberto C. Laurentino N. Manoel Jr Marco T. De Mello Maria E.P. Piemonte Patrícia C. Brum Claudia L. Forjaz Valmor Tricoli Carlos Ugrinowitsch 《Journal of Sports Science and Medicine》2014,13(3):597-603
This case report assessed quality of life, activities of daily living, motor symptoms, functional ability, neuromuscular parameters and mRNA expression of selected genes related to muscle protein synthesis and degradation in a patient with Multiple System Atrophy (MSA). The patient underwent resistance training with instability devices (i.e., bosu, dyna disk, balance disk, Swiss ball) for six months twice a week. After the six months training, the patient’s left and right quadriceps muscle cross-sectional area and leg press one-repetition maximum increased 6.4%, 6.8%, and 40%, respectively; the patient’s timed up and go, sit to stand, dynamic balance, and activities of daily living improved 33.3%, 28.6%, 42.3%, and 40.1%, respectively; the patient’s severity of motor symptoms and risk of falls decreased 32% and 128.1%, respectively. Most of the subscales of quality of life demonstrated improvements as well, varying from 13.0% to 100.0%. mRNA expression of mechanogrowth factor and mammalian target of rapamycin increased 12.7-fold and 1.5-fold, respectively. This case report describes likely the first nonpharmacological therapeutic tool that might be able to decrease the severity of motor symptoms and risk of falls, and to improve functional ability, neuromuscular parameters, and quality of the life in a patient with MSA.
Key points
- Six months of resistance training with instability alleviate the MSA-related effects and improve the quality of life in a patient with MSA.
- High complexity exercise intervention (i.e., resistance training with instability) may be very beneficial to individuals with impaired motor control and function as MSA patients.
- Caution should be exercised when interpreting our findings as they cannot be generalized to the entire MSA population and they do not allow establishing causal conclusions on the effects of this mode of exercise on MSA.
8.
L. Lamas M. S. Aoki C. Ugrinowitsch G. E. R. Campos M. Regazzini A. S. Moriscot V. Tricoli 《Scandinavian journal of medicine & science in sports》2010,20(2):216-225
The purpose of our study was to compare the effects of 8‐week progressive strength and power training regimens on strength gains and muscle plasticity [muscle fiber hypertrophy and phenotype shift, mammalian target of rapamycin (mTOR), regulatory‐associated protein of mTOR (RAPTOR), rapamycin‐insensitive companion of m‐TOR (RICTOR), calcineurin and calcipressin gene expression]. Twenty‐nine physically active subjects were divided into three groups: strength training (ST), power training (PT) and control (C). Squat 1 RM and muscle biopsies were obtained before and after the training period. Strength increased similarly for both ST and PT groups (P<0.001). Fiber types I, IIa and IIb presented hypertrophy main time effect (P<0.05). Only type IIb percentage decreased from pre‐ to post‐test (main time effect, P<0.05). mTOR and RICTOR mRNA expression increased similarly from pre‐ to post‐test (P<0.01). RAPTOR increased after training for both groups (P<0.0001), but to a greater extent in the ST (P<0.001) than in the PT group. 4EBP‐1 decreased after training when the ST and PT groups were pooled (P<0.05). Calcineurin levels did not change after training, while calcipressin increased similarly from pre‐ to post‐test (P<0.01). In conclusion, our data indicate that these training regimens produce similar performance improvements; however, there was a trend toward greater hypertrophy‐related gene expression and muscle fiber hypertrophy in the ST group. 相似文献
9.
Cruz Portela LV Oses JP Silveira AL Schmidt AP Lara DR Oliveira Battastini AM Ramirez G Vinadé L Freitas Sarkis JJ Souza DO 《Brain research》2002,950(1-2):74-78
Adenine and guanine nucleotides have been shown to exert multiple roles in central and peripheral nervous systems, and the sequential breakdown of these nucleotides by enzymatic systems is an important step in the modulation of their extracellular effects. The aim of this study was to investigate whether nucleotide hydrolysis also occurs in the cerebrospinal fluid (CSF) of rats. CSF was able to hydrolyze all guanine and adenine nucleotides investigated (2.0 mM): GDPADP=ATP=GTPAMP=GMP. More detailed studies with the diphosphate nucleotides showed that the hydrolysis of ADP and GDP was linear with incubation time and protein concentration. The apparent KM (Henry–Michaelis–Menten constant) and V (maximal velocity) values for ADP and GDP were 164.3±54.7 μM and 12.2±3.8 nmol Pi/min per mg protein, and 841.0±90.2 μM and 22.8±8.0 nmol Pi/min per mg protein. The sum of ADP, GDP and UDP hydrolysis (2.0 mM) upon individual incubations with CSF was similar to the hydrolysis observed when all three nucleotides were incubated together. This pattern of hydrolysis strongly suggests the involvement of more than one enzyme activity. The higher maximum activity for GDP and UDP compared to ADP is compatible with presence of a soluble NTDPase5. 相似文献
10.
A human genomic DNA segment (hal) which hybridizes with rat pancreatic amylase cDNA was used to regionally assign amylase genes in human-mouse somatic cell hybrids. The assignment of amylase genes to chromosome 1 was confirmed and regionally mapped to the short arm region p22.1p21 using a cell hybrid retaining a translocation involving chromosome 1 [46,XX,t(1;2)(p21;q37)]. Restriction length polymorphisms at the amylase loci are reported for gene linkage studies. 相似文献