全文获取类型
收费全文 | 6303篇 |
免费 | 249篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 35篇 |
儿科学 | 166篇 |
妇产科学 | 106篇 |
基础医学 | 805篇 |
口腔科学 | 80篇 |
临床医学 | 335篇 |
内科学 | 1707篇 |
皮肤病学 | 68篇 |
神经病学 | 398篇 |
特种医学 | 248篇 |
外科学 | 1134篇 |
综合类 | 20篇 |
预防医学 | 173篇 |
眼科学 | 84篇 |
药学 | 396篇 |
中国医学 | 19篇 |
肿瘤学 | 796篇 |
出版年
2023年 | 21篇 |
2022年 | 50篇 |
2021年 | 85篇 |
2020年 | 54篇 |
2019年 | 72篇 |
2018年 | 85篇 |
2017年 | 59篇 |
2016年 | 69篇 |
2015年 | 92篇 |
2014年 | 146篇 |
2013年 | 211篇 |
2012年 | 301篇 |
2011年 | 338篇 |
2010年 | 173篇 |
2009年 | 166篇 |
2008年 | 328篇 |
2007年 | 394篇 |
2006年 | 406篇 |
2005年 | 384篇 |
2004年 | 378篇 |
2003年 | 362篇 |
2002年 | 420篇 |
2001年 | 175篇 |
2000年 | 175篇 |
1999年 | 176篇 |
1998年 | 108篇 |
1997年 | 83篇 |
1996年 | 75篇 |
1995年 | 73篇 |
1994年 | 65篇 |
1993年 | 52篇 |
1992年 | 116篇 |
1991年 | 121篇 |
1990年 | 100篇 |
1989年 | 106篇 |
1988年 | 74篇 |
1987年 | 70篇 |
1986年 | 67篇 |
1985年 | 59篇 |
1984年 | 37篇 |
1983年 | 27篇 |
1982年 | 19篇 |
1981年 | 15篇 |
1980年 | 18篇 |
1979年 | 19篇 |
1970年 | 13篇 |
1969年 | 12篇 |
1968年 | 16篇 |
1967年 | 15篇 |
1966年 | 13篇 |
排序方式: 共有6570条查询结果,搜索用时 15 毫秒
1.
Toshiro Hara Rony Chanoch-Myers Nathan D. Mathewson Chad Myskiw Lyla Atta Lillian Bussema Stephen W. Eichhorn Alissa C. Greenwald Gabriela S. Kinker Christopher Rodman L. Nicolas Gonzalez Castro Hiroaki Wakimoto Orit Rozenblatt-Rosen Xiaowei Zhuang Jean Fan Tony Hunter Inder M. Verma Kai W. Wucherpfennig Itay Tirosh 《Cancer cell》2021,39(6):779-792.e11
- Download : Download high-res image (228KB)
- Download : Download full-size image
2.
Yuki Asada Kazuaki Kanda Kazuyuki Ozeki Toshiro Tanaka Yohei Mizuta Shigeru Kohno 《Nihon Shokakibyo Gakkai zasshi》2006,103(12):1372-1376
Two patients with mesenteric panniculitis are presented. In the first patient, a provisional diagnosis of ileus was made, based on the clinical features and imaging data. Laparotomic findings showed that the ileum was bound tightly by a fibrous strip and dilated, with thickened and swollen mesentery. Incision of the fibrous strip was performed, and the clinical symptoms were improved. The second patient was strongly suspected to have mesenteric panniculitis, from characteristic features on abdominal computed tomography and barium enema. Conservative therapy was effective in this case. We emphasize the variety of clinical courses in mesenteric panniculitis, requiring selection of the most suitable treatment. 相似文献
3.
4.
T Uno H Kondo Y Inoue Y Kawahata M Sotomura K Iuchi G Tsukamoto 《Journal of medicinal chemistry》1990,33(10):2929-2932
A series of novel pyridone carboxylic acids having a 4-hydroxypiperazinyl group at the 7-position of norfloxacin and ciprofloxacin were prepared. The in vivo antibacterial efficacies of these compounds were superior to those of corresponding piperazinyl derivatives. From the results of the studies on the pharmacokinetic profile and toxicity, the 4-hydroxypiperazinyl derivatives were confirmed to be pharmacologically superior to corresponding piperazinyl derivatives. Thus, a 4-hydroxypiperazinyl group was revealed to be a beneficial substituent for potential use in future quinolone antibacterials. 相似文献
5.
T Uno M Takamatsu Y Inoue Y Kawahata K Iuchi G Tsukamoto 《Journal of medicinal chemistry》1987,30(12):2163-2169
A series of 6-fluoro- and 6,8-difluoro-7-(azole substituted)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids were prepared. Structure-activity relationship studies indicated that the antibacterial potency was better when the 6,8-substituents were fluorine atoms and the 7-substituent was either 1-imidazolyl, 20, or 4-methyl-1-imidazolyl, 25. From the results of studies on pharmacokinetic profile and toxicity, 20 and 25 were found to possess excellent antibacterial activities and to show high blood levels after oral administration to mice with low toxicity. 相似文献
6.
Allergic Predisposition Among Infants with Bronchiolitis 总被引:1,自引:0,他引:1
Yoko Nagayama Nobukiyo Sakurai Toshiro Nakahara Masahiro Makuta Somei Kojima Shigeru Funabashi Akihito Honda 《The Journal of asthma》1987,24(1):9-17
Allergic predisposition among infants with bronchiolitis was examined. The number of infants with serum IgE exceeding mean +1 SD was 31/70 (44.3%). The rate of positive radioallergosorbent test (RAST) scores of 1 or more to mites, egg white, or milk was 31/71 (43.7%) and that of scores over 2 was 11/71 (15.5%). Eosinophils and/or mast cells were found in their nasal smears on several occasions. These results indicated that allergic predisposition may be observed among infants with bronchiolitis. 相似文献
7.
Tsuneharu Miki Yoichi Mizutani Hideyuki Akaza Seiichiro Ozono Taiji Tsukamoto Toshiro Terachi Katsusuke Naito Norio Nonomura Isao Hara Osamu Yoshida The Japan Blood Cell Transplantation Study Group for Testicular Germ Cell Tumor 《International journal of urology》2007,14(1):54-59
OBJECTIVE: Standard chemotherapy shows relatively low long-term survival in patients with poor-risk testicular germ cell tumor (GCT). First-line high-dose chemotherapy (HD-CT) may improve the result. High-dose carboplatin, etoposide, ifosfamide chemotherapy followed by autologous peripheral blood stem cell transplantation (PBSCT) was investigated as first-line chemotherapy in patients with advanced testicular GCT. METHODS: Fifty-five previously untreated testicular GCT patients with Indiana 'advanced disease' criteria received three cycles of bleomycin, etoposide and cisplatin (BEP) followed by one cycle of HD-CT plus PBSCT, if elevated serum tumor markers were observed after three cycles of the BEP regimen. RESULTS: Thirty patients were treated with BEP alone, because the tumor marker(s) declined to normal range. Twenty-five patients received BEP and HD-CT. One patient died of rhabdomyolysis due to HD-CT. Three and six (13% and 25%) out of 24 patients treated with BEP and HD-CT achieved marker-negative and marker-positive partial responses, respectively. The other patients achieved no change. Fifteen (63%) are alive and 14 (58%) are free of disease at a median follow-up time of 54 months. Severe toxicity included treatment-related death (4%). CONCLUSIONS: HD-CT with peripheral stem cell support can be successfully applied in a multicenter setting. HD-CT demonstrated modest anticancer activity for Japanese patients with advanced testicular GCT and was well tolerated. This regimen might be examined for further investigation in randomized trials in first-line chemotherapy for patients with poor-risk testicular GCT. 相似文献
8.
K Ouchi J Kameyama T Hoshikawa O Matsumoto S Ishiyama M Toyono M Tsukamoto 《Nihon Geka Gakkai zasshi》1990,91(2):262-265
It is well known that primary hyperparathyroidism is often associated with peptic ulcer. The purpose of this study is to confirm the relationship between the gastrin-levels before and after parathyroidectomy in fourteen patients with primary hyperparathyroidism, and to determine the localization of gastrin in the surgically resected parathyroid tumor. The results obtained were as follows: 1) Three patients had peptic ulcer (gastric ulcer and duodenal ulcer), the incidence being 21%. 2) The basal serum gastrin levels were 123.0% +/- 68.1 pg/ml before operation and decreased to 90.2 +/- 44.5 pg/ml after operation. In the 3 patients with slightly elevated gastrin levels, the mean level before operation was 209.1 +/- 61.2 pg/ml. The gastrin level decreased to 116.4 +/- 62.0 pg/ml after operation. 3) Gastrin immunoreactivity was detected in 10 out of 14 tumors and its localization was at the periphery of tumor cells. From these results, we conclude that extragastric gastrin secretion from parathyroid tumors may be one of the cause of peptic ulcer in patients with primary hyperparathyroidism. 相似文献
9.
T. Onishi T. Machida N. Iizuka K. Nakauchi H. Shirakawa F. Masuda S. Mochizuki H. Tsukamoto N. Harada 《Urological research》1990,18(5):313-318
Summary Utilizing two types of human renal carcinoma heterotransplanted in nude mice, we investigated the variations in hyperthermic effects (42.5°C for 30 min) caused by differences in tumor type with special reference to variations in tumor vascularity. In the hypovascular JRC1 strain, sporadic vascular dilation was observed throughout the tumors after heating. Destruction of tumor cells was observed mainly in the region of dilation. In the hypervascular JRC11 strain, homogenous vascular dilation was observed immediately after heating, mainly at the periphery of tumors. There was a decrease in the viability of cells in the center of the tumor. Therefore, the hypervascular tumors showed greater destruction mainly at the center where blood circulation was reduced. The range of necrosis was also greatly affected by the extent of vascular dilation caused by heating in hypovascular tumors. 相似文献
10.