全文获取类型
收费全文 | 10825篇 |
免费 | 779篇 |
国内免费 | 46篇 |
专业分类
耳鼻咽喉 | 98篇 |
儿科学 | 293篇 |
妇产科学 | 97篇 |
基础医学 | 1376篇 |
口腔科学 | 239篇 |
临床医学 | 1042篇 |
内科学 | 2250篇 |
皮肤病学 | 188篇 |
神经病学 | 1319篇 |
特种医学 | 761篇 |
外科学 | 1911篇 |
综合类 | 65篇 |
一般理论 | 4篇 |
预防医学 | 572篇 |
眼科学 | 204篇 |
药学 | 522篇 |
中国医学 | 8篇 |
肿瘤学 | 701篇 |
出版年
2024年 | 24篇 |
2023年 | 134篇 |
2022年 | 217篇 |
2021年 | 407篇 |
2020年 | 262篇 |
2019年 | 314篇 |
2018年 | 350篇 |
2017年 | 314篇 |
2016年 | 393篇 |
2015年 | 395篇 |
2014年 | 516篇 |
2013年 | 627篇 |
2012年 | 940篇 |
2011年 | 915篇 |
2010年 | 533篇 |
2009年 | 445篇 |
2008年 | 690篇 |
2007年 | 678篇 |
2006年 | 557篇 |
2005年 | 440篇 |
2004年 | 413篇 |
2003年 | 344篇 |
2002年 | 336篇 |
2001年 | 135篇 |
2000年 | 113篇 |
1999年 | 104篇 |
1998年 | 60篇 |
1997年 | 33篇 |
1996年 | 36篇 |
1995年 | 29篇 |
1994年 | 23篇 |
1993年 | 28篇 |
1992年 | 63篇 |
1991年 | 48篇 |
1990年 | 61篇 |
1989年 | 50篇 |
1988年 | 54篇 |
1987年 | 56篇 |
1986年 | 40篇 |
1985年 | 40篇 |
1984年 | 32篇 |
1983年 | 32篇 |
1982年 | 26篇 |
1979年 | 39篇 |
1978年 | 23篇 |
1977年 | 22篇 |
1976年 | 20篇 |
1974年 | 21篇 |
1973年 | 23篇 |
1972年 | 20篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
Kienbaum Peter Schaefer Maximilian S. Weibel Stephanie Schlesinger Tobias Meybohm Patrick Eberhart Leopold H. Kranke Peter 《Der Anaesthesist》2022,71(2):123-128
Die Anaesthesiologie - Auch wenn für Anästhesiologen über Jahrzehnte die Prophylaxe und Therapie postoperativer Schmerzen im Rahmen des postoperativen Patientenkomforts an vorderster... 相似文献
2.
Oliveira Gonalves Ana Sofia Panteli Dimitra Neeb Lars Kurth Tobias Aigner Annette 《The European journal of health economics》2022,23(1):47-57
The European Journal of Health Economics - The aims of this study were to assess whether there is a conceptual overlap between the questionnaires HIT-6 and EQ-5D and to develop a mapping algorithm... 相似文献
3.
Tobias Kisch Julia Maria Klemens Katharina Hofmann Eirini Liodaki Matthias Gierloff Dirk Moellmeier Felix Stang Peter Mailaender Jens Habermann Matthias Brandenburger 《Medicine》2015,94(41)
The regrowth of amputated digit tips represents a unique regenerative healing in mammals with subcutaneous volume regrowth, restoration of dactylogram, and suppression of scar formation. Although factor analysis in amphibians and even in mice is easy to obtain, safety of harvesting biomaterial from human digit tip amputations for analysis has not yet been described.The aim of this study was to evaluate if recovering wound exudate does hamper clinical outcome or influence microbiologic or inflammation status.A predefined cohort of 18 patients with fresh digit tip amputations was randomly assigned to receive standard therapy (debridement, occlusive dressing) with (n = 9) or without (n = 9) collection of the whole wound exudate in every dressing change. Primary endpoint (lengthening) and secondary endpoints (regeneration of dactylogram, nail bed and bone healing, time to complete wound closure, scar formation, 2-point discrimination, microbiologic analysis, inflammatory factors interleukin (IL)-1α, tumor necrosis factor-α, IL-4, and IL-6) were determined by an independent, blinded observer.Patients’ characteristics showed no significant differences between the groups. All patients completed the study to the end of 3 months follow-up. Exudate collection did not influence primary and secondary endpoints. Furthermore, positive microbiologic findings as well as pus- and necrosis-like appearance neither impaired tissue restoration nor influenced inflammatory factor release.Here, the authors developed an easy and safe protocol for harvesting wound exudate from human digit tip amputations. For the first time, it was shown that harvesting does not impair regenerative healing. Using this method, further studies can be conducted to analyze regeneration associated factors in the human digit tip.DRKS.de Identifier: DRKS00006882 (UTN: U1111-1166-5723). 相似文献
4.
5.
6.
The vagal nerve as a link between the nervous and immune system in the instance of polymicrobial sepsis 总被引:5,自引:0,他引:5
Wolfram Kessler Tobias Traeger Alexandra Westerholt Friederike Neher Marlene Mikulcak Antje Müller Stefan Maier Claus-Dieter Heidecke 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》2006,391(2):83-87
Background The role of the vagal nerve in the autonomic nervous system is widely well known. Recently, an additional function was revealed
serving as a connector between the nervous and immune system. This connection is called the “cholinergic inflammatory pathway.”
Through stimulation of the acetylcholine receptors located upon the macrophages, the “unspecific” immune system can be directly
influenced.
Methods The vagal nerve was completely transected directly posterior to its passage through the diaphragm. The effect of complete
vagotomy was analyzed using a murine model of polymicrobial peritonitis (colon ascendens stent peritonitis, CASP). Survival
and clinical course of vagotomized or sham-operated mice were analyzed in the CASP model.
Results After CASP surgery, vagotomy led to a significantly increased mortality (64.7%) in comparison to sham-vagotomized animals
(34%). No difference in the bacterial load of various tissues (lung, liver, spleen, blood, lavage fluid, and kidney) from
septic animals with or without vagotomy was observed. Vagotomized animals reveal elevated serum cytokine levels (TNF, IL-6,
IL-10, and MCP-1) 20 h after the induction of polymicrobial peritonitis.
Conclusion The vagal nerve is therefore an important modulator of the immune system.
W. Kessler and T. Traeger contributed equally to this work
Best of Forum Papers presented at the Annual Meeting of the German Society of Surgery, 2–5 May 2006, Berlin, Germany 相似文献
7.
P Pencharz J Beesley P Sauer J Van Aerde U Canagarayar J Renner M McVey D Wesson P Swyer 《The American journal of clinical nutrition》1989,50(6):1395-1400
The effects of nonprotein energy source (ie, glucose only vs glucose and lipid) on nitrogen retention and total-body protein turnover were studied in 20 parenterally fed newborn infants. All infants received approximately 3 g amino acids and 80-90 kcal.kg body wt.d. Total-body protein synthesis was estimated by using three constant-infusion, end-product methods: enrichment of urinary urea and ammonia in response to a [15N]glycine label and exhaled carbon dioxide enrichment in response to a [1-13C]leucine label. No differences were seen in nitrogen retention between the two energy sources. The estimate of total-body protein turnover obtained from the 13C label was similar to that obtained with the [15N]urea label. No differences in turnover rates were observed between the two diet groups. Use of the glucose-plus-lipid fuel system enhanced energy storage and the reutilization of amino acid for protein synthesis. 相似文献
8.
We appreciate to read Dr Komócsís comments toour article entitled Low response to clopidogrel is associatedwith cardiovascular outcome after coronary stent implantation. He critically remarked the mortality rate in our study. Indeed,we found an all-cause mortality of 5.2% within 3 months (cardiovascularmortality: 3.9%). However, it is worthy to note that we investigatedan unselected patient collective with moderate- to 相似文献
9.
10.
Genetic predisposition for adult lactose intolerance and relation to diet, bone density, and bone fractures. 总被引:8,自引:0,他引:8
Barbara M Obermayer-Pietsch Christine M Bonelli Daniela E Walter Regina J Kuhn Astrid Fahrleitner-Pammer Andrea Berghold Walter Goessler Vinzenz Stepan Harald Dobnig Georg Leb Wilfried Renner 《Journal of bone and mineral research》2004,19(1):42-47
Evidence that genetic disposition for adult lactose intolerance significantly affects calcium intake, bone density, and fractures in postmenopausal women is presented. PCR-based genotyping of lactase gene polymorphisms may complement diagnostic procedures to identify persons at risk for both lactose malabsorption and osteoporosis. INTRODUCTION: Lactase deficiency is a common autosomal recessive condition resulting in decreased intestinal lactose degradation. A -13910 T/C dimorphism (LCT) near the lactase phlorizin hydrolase gene, reported to be strongly associated with adult lactase nonpersistence, may have an impact on calcium supply, bone density, and osteoporotic fractures in the elderly. MATERIALS AND METHODS: We determined LCT genotypes TT, TC, and CC in 258 postmenopausal women using a polymerase chain reaction-based assay. Genotypes were related to milk intolerance, nutritional calcium intake, intestinal calcium absorption, bone mineral density (BMD), and nonvertebral fractures. RESULTS: Twenty-four percent of all women were found to have CC genotypes and genetic lactase deficiency. Age-adjusted BMD at the hip in CC genotypes and at the spine in CC and TC genotypes was reduced by -7% to -11% depending on the site measured (p = 0.04). LCT(T/C-13910) polymorphisms alone accounted for 2-4% of BMD in a multiple regression model. Bone fracture incidence was significantly associated with CC genotypes (p = 0.001). Milk calcium intake was significantly lower (-55%, p = 0.004) and aversion to milk consumption was significantly higher (+166%, p = 0.01) in women with the CC genotype, but there were no differences in overall dietary calcium intake or in intestinal calcium absorption test values. CONCLUSION: The LCT(T/C-13910) polymorphism is associated with subjective milk intolerance, reduced milk calcium intake, and reduced BMD at the hip and the lumbar spine and may predispose to bone fractures. Genetic testing for lactase deficiency may complement indirect methods in the detection of individuals at risk for both lactose malabsorption and osteoporosis. 相似文献