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排序方式: 共有246条查询结果,搜索用时 15 毫秒
1.
Angelo M. Carella Sandro Nati Paolo Carlier Daniela Pierluigi Domenico Giordano Angela Congiu Gino Santini Daniele Scarpati Salvina Barra Renzo Corvo Vito Vitale Maria R. Raffo Raffaella Cerri Marco Risso Mauro Spriano Renato Vimercati Ester Pungolino Andrea Bacigalupo Eugenio Damasio 《Leukemia & lymphoma》1991,5(1):43-47
Forty consecutive adult patients under the age of 50 with acute non-lymphoblastic leukemia (ANLL) in first complete remission, underwent autologous bone marrow transplantation (ABMT) between March 1984 and April 1990. The conditioning regimen employed included cyclophosphamide and total body irradiation, followed by the administration of unpurged ABMT. The median time from diagnosis to transplant was 7 months (3-15 months), and the median time from complete remission to ABMT was 4 months (range 3-9 months). Twenty-two (51%) patients remain in complete remission 6-81 months (median 24 months) after ABMT.
The causes of death were, recurrent leukemia (11 patients), parenchymal toxicities such as acute respiratory distress syndrome and veno-occlusive disease (3 patients), hemorrhage (2 patients) and infection (2 patients). Eleven patients relapsed after 3-12 months (median 5 months). This study has produced survival data comparable to those of other institutions employing TBI for either allo or autotransplants. 相似文献
The causes of death were, recurrent leukemia (11 patients), parenchymal toxicities such as acute respiratory distress syndrome and veno-occlusive disease (3 patients), hemorrhage (2 patients) and infection (2 patients). Eleven patients relapsed after 3-12 months (median 5 months). This study has produced survival data comparable to those of other institutions employing TBI for either allo or autotransplants. 相似文献
2.
A M Carella P Carlier A Congiu D Occhini S Nati G Santini D Pierluigi D Giordano A Bacigalupo E Damasio 《Bone marrow transplantation》1991,8(2):99-103
Fifteen patients with very poor prognosis Hodgkin's disease in remission after MOPP/ABVD regimen, were treated with high-dose chemotherapy (HDC) and autologous marrow transplantation (ABMT) immediately after achieving complete remission (CR). Thirteen patients (86.6%) remain alive in unmaintained CR at a median time of 36 months (range 10-64 months) post-transplant. In the other two patients reasons for failure included relapse of Hodgkin's disease (one patient) and death due to interstitial pneumonitis secondary to carmustine therapy. These patients were compared with a historical control group consisting of 24 patients with the same poor prognostic factors, who achieved CR with MOPP/ABVD and did not receive other treatment. Eight out of 24 patients (33%) remain alive and well in unmaintained CR at a median time of 42 months (range 19-83 months). The administration of MOPP/ABVD combined with HDC and ABMT was not associated with an increased incidence of major toxicity. The results achieved support the early sequential treatment of a highly effective drug combination followed by HDC/ABMT that can substantially improve the likelihood of cure in these advanced stage very poor prognosis Hodgkin's disease patients. 相似文献
3.
Francesco Muntoni Anna Mateddu Maria Giovanna Marrosu Miiena Cau Rita Congiu Maria Antonietta Melis Antonio Cao Carlo Cianchetti 《Clinical genetics》1992,42(1):35-38
The majority of Duchenne muscular dystrophy (DMD) female carriers show dystrophin immunostaining abnormalities, although a significant proportion of clinically non-manifesting carriers are normal following this analysis. We had the opportunity to study dystrophin immunostaining in two different muscles, the vastus lateralis and the rectus abdominis of a possible DMD carrier. While the vastus showed normal dystrophin immunostaining, pathological staining was detected in her rectus abdominis. These findings seem to indicate that dystrophin expression can vary in different muscle groups of a DMD carrier. The implications of these findings in DMD carrier detection and possible dystrophin function are discussed. 相似文献
4.
Castagnola M Congiu D Denotti G Di Nunzio A Fadda MB Melis S Messana I Misiti F Murtas R Olianas A Piras V Pittau A Puddu G 《Journal of chromatography. B, Biomedical sciences and applications》2001,751(1):153-160
A reversed-phase high-performance liquid chromatography (HPLC) method with diode-array detection for the quantification of several human salivary peptides is described. Sample pretreatment consisted of the acidification of whole saliva by phosphate buffer. This treatment produced precipitation of mucins, alpha-amylases and other high-molecular-mass salivary proteins, simultaneous inhibition of intrinsic protease activities and reduction of sample viscosity. Direct HPLC analysis by diode-array detection of the resulting acidic sample allowed one to quantify histatin 1, histatin 3, histatin 5, statherin, as well as uric acid, in normal subjects. Moreover, the groups of peaks pertaining to proline-rich proteins and cystatins were tentatively identified. The method can be useful in assessing the concentration of salivary peptides from normal subjects and from patients suffering oral and/or periodontal diseases. 相似文献
5.
Riva A Congiu T Lantini MS Puxeddu R Riva FT 《Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia》1995,100(Z1):367-374
The secretory and ductal cells of human salivary glands have been studied at Scanning Electron Microscopy (SEM) by our modification of the Aldehyde-Osmium-DMSO-Osmium (A-ODO) maceration method which enables the analytical study of human bioptical specimens. The most interesting results are those concerning the visualization of the cytoplasmic aspect of intercellular canaliculi of serous cells and of mitochondria of ductal cells. The canaliculi appear as elongated cylindrical structures fenestrated by holes correspohding to the bases of microvilli deprived of the cytoskeleton. Mitochondria of principal cells are longer and more complex than previously reported. 相似文献
6.
A Olivieri G Santini C Patti T Chisesi C De Souza A Rubagotti S Aversa A Billio A Porcellini M Candela R Centurioni A M Congiu M Brunori S Nati M Spriano R Vimercati G Marino A Contu L Tedeschi I Majolino M Crugnola M R Sertoli 《Annals of oncology》2005,16(12):1941-1948
BACKGROUND: There is not univocal concordance for using high-dose sequential therapy (HDS) as first-line treatment for aggressive non-Hodgkin's lymphoma (NHL). We designed this study to evaluate the usefulness of HDS followed by high-dose therapy (HDT) with autologous stem cell transplantation as front-line treatment in different subsets of aggressive NHL. PATIENTS AND METHODS: Among 223 patients aged 15-60 years with aggressive, advanced stage NHL, 106 patients were randomized to VACOP-B (etoposide, doxorubicin, cyclophosphamide, vincristine, prednisone, bleomycin) for 12 weeks (plus HDS/HDT in case of persistent disease) (arm A), and 117 patients to VACOP-B for 8 weeks plus upfront HDS/HDT (arm B). RESULTS: According to the intention-to-treat analysis, the complete response rate was 75% for arm A and 72.6% for arm B. With a median follow-up of 62 months there was no difference in 7-year probability of survival (60% and 57.8%; P = 0.5), disease-free survival (DFS) (62% and 71%; P = 0.2) and progression-free survival (PFS) (44.9% and 40.9%; P = 0.7) between the two arms. Subgroup analyses confirmed that the best results in terms of survival, DFS and PFS were achieved by patients with large B-cell NHL without bone marrow (BM) involvement, independently of the treatment arm. Results were poorer in other categories of patients and poorest in patients with BM involvement. CONCLUSIONS: Aggressive NHL patients do not benefit from upfront HDS/HDT. 相似文献
7.
8.
In isolated rat hepatocytes N-acetylcysteine induces an increase of lipid peroxidation, as evaluated by the malondialdehyde production and diene conjugation. Lipid peroxidation did not result in increased cell mortality. Antioxidants and free radicals scavengers completely protect toward lipid peroxidation induced by N-acetylcysteine. 相似文献
9.
Background: Comparative gene expression is commonly determined with reference to the expression of a housekeeping gene (HKG), the level of which is assumed to be unregulated. There are little data to date on the effect of disease on the expression of classic HKGs in hepatitis C virus (HCV)‐infected human liver. Aims: To identity HKGs stable across a wide spectrum of disease in human HCV‐infected liver. Methods: β‐Actin, hypoxanthine phosphoribosyltransferase 1 (HPRT1), glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH), splicing factor arginine/serine‐rich 4, β‐glucuronidase and 18S ribosomal RNA (18S rRNA) were measured by real‐time polymerase chain reaction in liver biopsy tissue. Samples were categorised for inflammation, fibrosis and steatosis, and allocated into groups with mild or severe liver disease. Values were analysed using Spearman's rank correlation, NormFinder, BestKeeper and geNorm programs. Results: All genes performed well in the samples of patients with low disease activity, but HPRT1, β‐actin, GAPDH and 18S rRNA ranked poorly in samples with severe fibrosis or inflammation. Conclusions: Our results indicate that liver disease affects the expression of common HKGs and that β‐glucuronidase and splicing factor arginine/serine‐rich 4 are the most stable HKGs from this group for studies of gene expression in HCV‐infected human liver. 相似文献