青蒿琥酯皮肤擦剂在小鼠和兔体内的药代动力学研究

将青蒿琥酯溶于苯二甲酸二甲酯,加适量氨酮制成皮肤擦剂。给兔脱毛后,皮肤涂抹此擦剂25mg/kg后,血药浓度达峰时间平均为2 h,峰浓度平均为1.80μg/ml。药物在兔体内平均驻留时间为3.54 h,清除半衰期约为2.46 h。给小鼠脱毛皮肤涂抹擦剂6.7,31.3和71.4 mg/kg,血药浓度在给药后0.5～4 h达高峰,峰浓度分别为0.82,2.05和7.11μg/ml,体内药物平均驻留时间为3.39,2.79及3.54 h,清除半衰期为2.35,1.93及2.45 h。可见,给兔及小鼠皮肤擦剂后,青蒿琥酯吸收良好,血药浓度维持时间较长。     

A review of the functional electrical stimulation equipment market

The market for functional electrical stimulation (FES) equipment for use in rehabilitation is growing as increasingly sophisticated products enter the market each year. Factors that impact the availability of FES equipment include technological limitations, government regulation, reimbursement status, and clinician training. New products have become available in the last decade with many innovative applications available under investigational status. The current availability of FES equipment for selected applications such as therapeutic muscle stimulation, cardiovascular exercise, restoration of function in the lower and upper extremities, respiratory assist, restoration of bladder function, electroejaculation, and scoliosis correction is reviewed. A review of FES equipment for nonneuromuscular applications such as control of epilepsy, cochlear implants, electrotactile stimulation, and systems to enhance wound healing and bone growth is also included. Key manufacturers are identified.     

Repeatability of measuring knee flexion angles with wearable inertial sensors

Background

As assessment with inertial-measurement-units (IMUs) increases in research and in clinics, it is important to be aware of the repeatability of these sensors. The objectives of this experiment were to evaluate the measurement repeatability of IMU joint angles using a repeatable robot controller and an anthropomorphic leg phantom and to determine effects of joint speed and sensor positioning on the angles collected by these sensors. Comparisons to an electro-goniometer and three-dimensional (3D) motion capture cameras were also completed.