Pattern of hyperlipidemia in rats with chronic renal failure

The character of the hyperlipidemia was studied in rats with chronic uremia caused by removal of five-sixths of the total weight of kidney tissue. The blood cholesterol and phospholipid concentrations were almost twice the normal level 13–30 days after subtotal nephrectomy in the rats with uremia. The hyperlipidemia was more marked when the blood nonprotein nitrogen level was high. The serum triglyceride concentration was not increased. The total concentration of serum -and pre--lipoproteins, determined nephelometrically, was significantly increased only if the nonprotein nitrogen exceeded 80 mg%. Disk electrophoresis of the serum lipoproteins of the rats with uremia revealed a definite increase in the -lipoprotein concentration and a very small increase in the -lipoprotein concentration. Postheparin plasma lipolytic activity in the rats with uremia was normal. Massive proteinuria was observed in the experimental rats, but the hypoproteinemia was not significant.Nephrology Problem Laboratory, I. M. Sechenov First Moscow Medical Institute. Pathomorphological Laboratory, Institute of Nutrition, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR E. M. Tareev.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 85, No. 6, pp. 676–679, June, 1978.     

A method of determining Campylobacter pylori in the gastric mucosa in peptic ulcer and chronic gastritis

An original method is described for the detection of Campylobacter pylori in gastric mucosa biopsy specimens in chronic gastritis and gastroduodenal ulcers. The method is based on the detection (by a special test) of extremely high urease activity of C. pylori. The method has been employed in examinations of 211 patients. The results and prospects for the use of this technique for the detection of C. pylori in patients with gastroduodenal diseases are discussed.     

An automated method of detecting bacteriuria]

A screening test for bacteriuria was developed, based on the use of the Bioscreen microbiological system (Labsystem, Finland) and nutrient media manufactured in the USSR. The diagnostic characteristics of the new test were assessed in screening of inpatients; the test has proved to be not inferior to similar methods realized in the microbiological systems manufactured in Western Europe and USA.