Häufung von Malariatodesfällen nac Salvarsaninjektionen

Ohne Zusammenfassung     

Observations on the chemical and physiological properties of urodiolenone, an urinary compound found in hypertension

Urodiolenone is a substance that appears as the glucuronide in the urine of 1 in 3 hypertensive subjects. It is a potent inhibitor of Na+, K+-ATPase in kidney tissue of the guinea pig, as measured by cytochemical assay. Chemical and mass spectrometric evidence is presented, from which it is concluded that urodiolenone is a sesquiterpenoid substance, is a bicyclic enone with a vicinal diol side chain, and has molecular formula C15H24O3.     

Zur Kenntnis der Keratodermia maculosa disseminata symmetrica (Buschke-Fischer)

Ohne Zusammenfassung     

Vergiftungen

International Journal of Legal Medicine -     

Die Kalk-Salvarsan-Therapie

Ohne Zusammenfassung     

Syringomyelie auf syphilitischer Grundlage

Ohne Zusammenfassung     

mTORC2 regulates multiple aspects of NKT‐cell development and function

Invariant NKT (iNKT) cells bridge innate and adaptive immunity by rapidly secreting cytokines and lysing targets following TCR recognition of lipid antigens. Based on their ability to secrete IFN‐γ, IL‐4 and IL‐17A, iNKT‐cells are classified as NKT‐1, NKT‐2, and NKT‐17 subsets, respectively. The molecular pathways regulating iNKT‐cell fate are not fully defined. Recent studies implicate Rictor, a required component of mTORC2, in the development of select iNKT‐cell subsets, however these reports are conflicting. To resolve these questions, we used Rictor^fl/fl CD4cre⁺ mice and found that Rictor is required for NKT‐17 cell development and normal iNKT‐cell cytolytic function. Conversely, Rictor is not absolutely required for IL‐4 and IFN‐γ production as peripheral iNKT‐cells make copious amounts of these cytokines. Overall iNKT‐cell numbers are dramatically reduced in the absence of Rictor. We provide data indicating Rictor regulates cell survival as well as proliferation of developing and mature iNKT‐cells. Thus, mTORC2 regulates multiple aspects of iNKT‐cell development and function.     

Über Keratodermia maculosa disseminata symmetrica palmaris et plantaris (Buschke-Fischer)

Ohne ZusammenfassungMit 3 Textabbildungen.     

Über multiple neurotische Hautgangrän und ihre Beziehungen zur inneren Sekretion

Ohne Zusammenfassung