全文获取类型
收费全文 | 26748篇 |
免费 | 1296篇 |
国内免费 | 133篇 |
专业分类
耳鼻咽喉 | 349篇 |
儿科学 | 424篇 |
妇产科学 | 493篇 |
基础医学 | 3397篇 |
口腔科学 | 657篇 |
临床医学 | 1905篇 |
内科学 | 7185篇 |
皮肤病学 | 322篇 |
神经病学 | 2067篇 |
特种医学 | 817篇 |
外科学 | 4534篇 |
综合类 | 119篇 |
一般理论 | 1篇 |
预防医学 | 865篇 |
眼科学 | 429篇 |
药学 | 1855篇 |
中国医学 | 46篇 |
肿瘤学 | 2712篇 |
出版年
2022年 | 233篇 |
2021年 | 465篇 |
2020年 | 270篇 |
2019年 | 301篇 |
2018年 | 439篇 |
2017年 | 339篇 |
2016年 | 420篇 |
2015年 | 436篇 |
2014年 | 600篇 |
2013年 | 754篇 |
2012年 | 1156篇 |
2011年 | 1279篇 |
2010年 | 702篇 |
2009年 | 631篇 |
2008年 | 1205篇 |
2007年 | 1269篇 |
2006年 | 1238篇 |
2005年 | 1161篇 |
2004年 | 1163篇 |
2003年 | 1161篇 |
2002年 | 1201篇 |
2001年 | 929篇 |
2000年 | 974篇 |
1999年 | 858篇 |
1998年 | 349篇 |
1997年 | 274篇 |
1996年 | 259篇 |
1995年 | 227篇 |
1994年 | 187篇 |
1993年 | 164篇 |
1992年 | 630篇 |
1991年 | 662篇 |
1990年 | 563篇 |
1989年 | 575篇 |
1988年 | 556篇 |
1987年 | 516篇 |
1986年 | 449篇 |
1985年 | 451篇 |
1984年 | 339篇 |
1983年 | 259篇 |
1979年 | 249篇 |
1978年 | 159篇 |
1977年 | 154篇 |
1974年 | 144篇 |
1973年 | 128篇 |
1972年 | 143篇 |
1971年 | 135篇 |
1970年 | 125篇 |
1969年 | 140篇 |
1967年 | 140篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
Taichi Goto Gojiro Nakagami Takeo Minematsu Sanai Tomida Masamichi Shinoda Koichi Iwata Hiromi Sanada 《Experimental dermatology》2019,28(9):1010-1016
Cutaneous wound pain causes physical and psychological stress for patients with wounds. Previous studies reported that stress induces hyperalgesia and deteriorates wound healing. However, the effect of the stress response such as in hypothalamic‐pituitary‐adrenal (HPA) axis on local wound area is unclear. We aimed to investigate the effects of a stress response on the mechanical withdrawal threshold in the local wound area and describe the identification of a wound pain exacerbation. We topically injected adrenocorticotropic hormone (ACTH) into the granulation tissue of full‐thickness cutaneous wound model rats on the fifth day postwounding and measured the mechanical withdrawal thresholds, cytochrome P450 2Bs levels and concentration of 5,6‐epoxyeicosatrienoic acid in wound exudate. We found that ACTH induced mechanical hypersensitivity at 4 and 6 hours after injection (P = .004 and .021, respectively), and increased gene expression of cytochrome P450 2B12 expression (P = .046). Concentration of 5,6‐EET in the wound exudate was moderately correlated with the mechanical withdrawal threshold (r = ?.630). Finally, the mechanical withdrawal threshold in the 5,6‐EET group was significantly lower than that in the control group at 2 hours after the injection (P = .015). We propose that 5,6‐EET is one of the most promising contributors to the wound pain exacerbation. These findings could guide clinical wound and pain management. 相似文献
6.
7.
Koji Saito Takashi Saito Sumio Kawada 《Nihon Shokakibyo Gakkai zasshi》2006,103(10):1176, 1179-1176, 1180
8.
Masahiro Yamauchi Hiroko Kusano Etsuko Saito Takeshi Iwata Masashi Nakakura Yasuki Kato Takaaki Uochi Shiro Akinaga Noboru Aoki 《Journal of controlled release》2006,114(2):268-275
Previously, we demonstrated that wrapping dextran fluorescein anionic/cationic lipid complexes with neutral lipids produced a stable formulation that markedly increased the duration of the compound in plasma after intravenous administration to rats. The improved drug-delivery properties of the wrapped liposomes (WL) relative to other formulations suggested that this technology could offer important advantages for the administration of other polyanionic drugs, including antisense oligodeoxynucleotides (ODN). In the present study, we investigated the value of WL for formulating fluorescence-labeled phosphorothioated ODN (F-ODN). WL encapsulating F-ODN/cationic lipid complexes were prepared efficiently using similar methodology to that used in our earlier study. Studies confirmed that these WL were stable in vitro. Following intravenous administration to mice, free F-ODN and naked F-ODN/cationic lipid complexes were rapidly eliminated whereas administration of the WL resulted in high blood concentrations of drug that were maintained for several hours. Additional studies were conducted in mice that were inoculated with tumor cells (Caki-1 xenograft model, human kidney); in these experiments, intravenous administration of WL delivered 13 times more F-ODN to the tumor site than achieved after injection of free F-ODN. 相似文献
9.
10.
Y Ohtsuka X-T Wang J Saito T Ishida M Munakata 《The European respiratory journal》2006,28(5):1013-1019
Inter-individual variations in the development of silicosis, even within the same environments, have been reported, which suggest the contribution of genetic factors in silicosis aetiology. The aim of the present study was to determine whether there is any significant genetic influence on the development of silicosis. Furthermore, which genetic loci are responsible for the pulmonary response to silica exposure? Eight strains of inbred mice were used to examine the genetic influence on the lung fibrotic response to silica exposure. After intercross-breeding between the most susceptible and most resistant strains, a genome-wide linkage analysis of quantitative trait loci (QTL) was performed. Hydroxyproline was applied as an index, and genotypes of 167 marker genes were analysed by fragment analysis using a capillary-type sequencer. There was significant inter-strain difference in the mean concentration of hydroxyproline contents among the eight strains of mice. Breeding studies were conducted between the most susceptible, C57BL/6J, and the most resistant strain, CBA/J. A genome-wide linkage analysis of silica-exposed intercrossed cohorts identified significant QTL on chromosome 4 and suggestive QTL on chromosomes 3 and 18. The present study demonstrates that genetic factors may play a significant role in fibrotic-lung responses to silica; one significant and two suggestive quantitative trait loci were identified. 相似文献