全文获取类型
收费全文 | 1501篇 |
免费 | 71篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 137篇 |
妇产科学 | 27篇 |
基础医学 | 190篇 |
口腔科学 | 105篇 |
临床医学 | 73篇 |
内科学 | 283篇 |
皮肤病学 | 41篇 |
神经病学 | 97篇 |
特种医学 | 82篇 |
外科学 | 259篇 |
综合类 | 2篇 |
预防医学 | 31篇 |
眼科学 | 98篇 |
药学 | 39篇 |
肿瘤学 | 106篇 |
出版年
2023年 | 6篇 |
2022年 | 8篇 |
2021年 | 26篇 |
2020年 | 9篇 |
2019年 | 18篇 |
2018年 | 38篇 |
2017年 | 7篇 |
2016年 | 33篇 |
2015年 | 23篇 |
2014年 | 34篇 |
2013年 | 46篇 |
2012年 | 89篇 |
2011年 | 63篇 |
2010年 | 57篇 |
2009年 | 39篇 |
2008年 | 60篇 |
2007年 | 60篇 |
2006年 | 58篇 |
2005年 | 62篇 |
2004年 | 78篇 |
2003年 | 77篇 |
2002年 | 63篇 |
2001年 | 63篇 |
2000年 | 64篇 |
1999年 | 52篇 |
1998年 | 23篇 |
1997年 | 15篇 |
1996年 | 22篇 |
1995年 | 17篇 |
1994年 | 16篇 |
1993年 | 18篇 |
1992年 | 34篇 |
1991年 | 23篇 |
1990年 | 27篇 |
1989年 | 28篇 |
1988年 | 29篇 |
1987年 | 25篇 |
1986年 | 28篇 |
1985年 | 18篇 |
1984年 | 13篇 |
1983年 | 18篇 |
1982年 | 7篇 |
1981年 | 11篇 |
1980年 | 10篇 |
1978年 | 9篇 |
1977年 | 9篇 |
1973年 | 5篇 |
1972年 | 6篇 |
1971年 | 8篇 |
1967年 | 4篇 |
排序方式: 共有1578条查询结果,搜索用时 15 毫秒
1.
Eloise R. Galligan Lindsey Fix Sameera Husain Philip Zachariah Darrell J. Yamashiro Christine T. Lauren 《Journal of cutaneous pathology》2019,46(2):159-161
We report a case of disseminated Trichosporon asahii in a patient on systemic antifungal therapy who presented with multiple cutaneous nodules suggestive of fungal infection. Histologic features resembled neutrophilic eccrine hidradenitis but staining with periodic acid‐Schiff and Gomori methenamine silver confirmed the clinical diagnosis. This case highlights the importance of maintaining suspicion for trichosporonosis and contextualizing histologic findings within the underlying clinical picture. 相似文献
2.
Aro Ino Tatsuya Hayashi Kazunori Yamashiro Tetsuji Cho Toshifumi Kishimoto 《Nihon Arukōru Yakubutsu Igakkai zasshi》2005,40(1):47-56
One hundred fifty-three inpatients with alcohol dependence syndrome were treated with the structured BDIM (Before-Discharge Intervention Method). 82 patients of them have participated to self-help group meetings or kept having therapy as our outpatients or inpatients during the study period. We chose the families of the 82 patients as our study subject Out of the study subjects who took part in BDIM, 64 families (117 persons) answered our questionnaire. Among them 63 families (101 persons) gave their described answers of impressions and opinions about BDIM, which were summarized as follows. (1) Through BDIM the family members gained second thought on their alcoholic family member (IP: identified patient) and they could tell their new view to IP. BDIM enabled them to tell IP their sincere feeling and hope for recovery of IP. BDIM empowered both IP and IP's family members. (2) The family members became to know IP's orientation on his or her disease. They came to know IP's denial and understand him or her as he or she was. (3) The family members felt emotional ties among themselves and IP through BDIM. When the family members of a dysfunctional family took part together in BDIM, they could know the feelings, thoughts, experiences and hopes one another. The family members had a precious experience of mutual understanding among themselves and IP to hope for recovery together. (4) The family members appreciated BDIM as a effective therapy. In BDIM many of them regarded highly of giving their letters to IP as a useful method to convey their feeling and thoughts calmly to IP. (5) On the other hand some family members pointed out the difficulty for themselves to write on BDIM. For family members who are not good at writing a letter or tend only to blame IP through their letters, writing and giving letters to IP is not appropriate as a therapy. If family members feel strong anxiety or fear, it is safe not to practice BDIM. 相似文献
3.
4.
Yasuhiro Sano Shigeharu Yamashiro Asuka Komano Hisashi Maruko Hiroshi Sekiguchi Yasuo Takayama Ryoji Sekioka Kouichiro Tsuge Isaac Ohsawa Mieko Kanamori-Kataoka Yasuo Seto Akiyoshi Satoh 《Forensic Toxicology》2007,25(2):76-79
We previously reported that the Guardian Bio-Threat Alert (BTA) system could detect (detection limit: about 0.1 μg/ml) staphylococcal
enterotoxin B (SEB), botulinum toxins (BTX) A and B, and ricin, with no interference by white-powdered materials or colored
matrices. In this study, the capability of the BTA system was further assessed. With 10 min of preheating at 60°C, all toxins
could be detected, but with preheating at 80°C, BTX A and B and ricin became undetectable. About 20% SEB could be detected
after heating at 80°C, but this detection ability was completely removed after heating at 100°C. The effects of chemicals
usually used for decontamination, such as sodium hypochlorite, hydrogen peroxide, formaldehyde, and sodium nitrite, on the
detectability of SEB, BTX A, or ricin in the BTA system were also tested. The concentrations giving 50% line intensity for
SEB, BTX A, and ricin were 3.1, 11, and 15 μM for sodium hypochlorite and 88, 210, and 60 mM for formaldehyde, respectively.
The addition of hydrogen peroxide or sodium nitrite did not decrease the detectability even when used at high concentrations. 相似文献
5.
6.
Kazuo Kitagawa Masayasu Matsumoto Keisuke Kuwabara Masafumi Tagaya Toshiho Ohtsuki Ryuji Hata Hirokazu Ueda Nobou Handa Kazufumi Kimura Takenobu Kamada 《Brain research》1991,561(2)
We investigated the effects of mild and non-lethal ischemic insult on neuronal death following subsequent lethal ischemic stress in various brain regions, using a gerbil model of bilateral cerebral ischemia. Single 10-min ischemia consistently caused neuronal damage in the hippocampal CA1, CA2, CA3 and CA4, layer III/IV of the cerebral cortex, dorsolateral part of the caudoputamen and ventrolateral part of the thalamus. On the other hand, in double ischemia groups, 2-min ischemic insult 2 days before 10-min ischemia exhibited significant protection in the CA1 and CA3 of the hippocampus, the cerebral cortex, the caudoputamen and the thalamus. Five-min ischemic insult 2 days before 10-min ischemia also showed protective effect in the same areas as those of 2-min ischemia except for the CA1 region of the hippocampus, while 1-min ischemic insult exhibited no protective effect in any brain regions. In the immunoblot analysis, both 2- and 5-min ischemia caused increased synthesis of heat shock protein 72 (HSP 72) in the hippocampus, but 1-min ischemia did not. The present study demonstrated that the ‘ischemic tolerance’ phenomenon was widely found in the brain and also suggested that ischemic treatment severe enough to cause HSP 72 synthesis might be needed for induction of ‘ischemic tolerance’. 相似文献
7.
Tadahito Kanda Takashi Onda Soichi Zanma Toshiharu Yasugi Akemi Furuno Sumie Watanabe Takashi Kawana Motoyasu Sugase Kuniaki Ueda Takahiko Sonoda Saburo Suzuki Takenobu Yamashiro Hiroyuki Yoshikawa Kunito Yoshiike 《Virology》1992,190(2)
The E4 open reading frame (ORF) of human papillomaviruses (HPVs) is transcribed in abundant mRNAs encoding an
fusion gene during the productive infection, and the HPV 16 E7 ORF encodes an oncoprotein detectable in the cell lines derived from cervical carcinoma. We examined 421 human sera, which included 108 samples from the patients with cervical carcinoma, for the presence of IgG antibodies against the HPV 16 E4 and E7 proteins by enzyme-linked immunosorbent assay. Bacterially expressed fusion protein lac-
and nonfusion protein E7 were purified and used as antigens. All of the 22 serum samples positive for anti-E7 antibody and the 11 out of 15 samples positive for anti-
antibody were from the patients with cervical carcinoma, but only one sample was found to contain both anti-
and anti-E7 antibodies. These findings show specific and independent association of these antibodies with cervical carcinoma. 相似文献
8.
M Yoshida T Takahashi H Hashimoto T Noro Y Hino T Hirashima H Terashima H Tsubuku N Wakakuri M Yamashiro 《Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics》1992,29(11):836-840
A 10-year experience with 2,441 patients over 65 years of age undergoing operations for non-upper gastrointestinal tracts was reviewed to evaluate both the incidence of postoperative upper gastrointestinal bleeding and the clinical risk factors associated with the complication. A total of 18 (0.7%, 7 males and 11 females) patients had overt postoperative upper gastrointestinal bleeding of non-variceal origin documented by endoscopic findings or blood transfusions. Of these, the complication developed in 10 (1.5%) of 646 patients after an operation for biliary or pancreatic disease, 1 (1.5%) of 64 for aneurysmal or obstructive arterial disease, 5 (1.1%) of 43 for colorectal cancer and 2 (0.3%) of 916 for hernia. The incidences of bleeding after an operation for obstructive jaundice (3.8%), for biliary or pancreatic malignancy (4.5%), and of unavoidable diversion colostomy for colorectal anastomosis (3.1%) were significantly higher than for non-jaundice (0.6%), for non-malignancy (1.1%) and of postoperative upper gastrointestinal bleeding in the present study. The origins of bleeding were gastric ulcer in 11, acute gastric mucosal lesion in 4, duodenal ulcer in 1 and other in 2. All cases of bleeding were treated and met success in hemostasis using H2-blockers. Of these, however, 5 patients died of multiple organ failure despite discontinued hemorrhage, prophylactic use of H2-blockers showed a decrease in occurrence of postoperative upper gastrointestinal bleeding in the present study. 相似文献
9.
Seigo Nagao Fumiyuki Momma Tsukasa Nishiura Takenobu Murota Masakazu Suga 《Experimental neurology》1986,92(3):553-562
The correlation of changes in cortical neuron activity with water content and local cerebral blood flow was investigated in cats with brain edema produced by air exposure. The further effect of high-dose methylprednisolone on these factors was studied. Six hours after exposure of the brain surface to air, the water content of the white matter significantly increased. The local blood flow of the cortex and white matter significantly decreased with significant suppression of cortical neural activity (direct cortical response), indicating that ischemia was responsible for neural suppression. A single, large dose of methylprednisolone (30 mg/kg, i.v.) at the beginning of air exposure significantly reduced brain edema of the cortex and white matter 12 h after air exposure and improved the local blood flow of the cortex. Methylprednisolone also caused a remarkable improvement in cortical neural activity. This steroid effect on cortical neural function may play a role in the rapid neurologic improvement observed with their use in addition to the effect on brain edema. 相似文献
10.
Toshifumi Gabata Masumi Kadoya Osamu Matsui Masashi Yamashiro Tsutomu Takashima Donald G. Mitchell Yasutaka Nakamura Kazuo Takeuchi Yasuni Nakanuma 《Journal of magnetic resonance imaging : JMRI》1998,8(2):503-504
We reported a case of the biliary cystadenoma of the liver. The cystic mass had labulation and septation and showed marked hyperintensity on T1-weighted images and hypointensity on T2-weighted images; MR findings were very unusual for cystadenoma. The content of the cystic mass was jelly-like, thick mucinous fluid without intracystic hemorrhage. We concluded that these unusual signal intensities of the cyst were due to hyperproteinous mucinous fluid. 相似文献