全文获取类型
收费全文 | 5248篇 |
免费 | 302篇 |
国内免费 | 36篇 |
专业分类
耳鼻咽喉 | 33篇 |
儿科学 | 58篇 |
妇产科学 | 67篇 |
基础医学 | 640篇 |
口腔科学 | 173篇 |
临床医学 | 308篇 |
内科学 | 1602篇 |
皮肤病学 | 269篇 |
神经病学 | 340篇 |
特种医学 | 135篇 |
外科学 | 788篇 |
综合类 | 25篇 |
预防医学 | 155篇 |
眼科学 | 42篇 |
药学 | 290篇 |
中国医学 | 5篇 |
肿瘤学 | 656篇 |
出版年
2023年 | 53篇 |
2022年 | 126篇 |
2021年 | 182篇 |
2020年 | 84篇 |
2019年 | 104篇 |
2018年 | 146篇 |
2017年 | 114篇 |
2016年 | 139篇 |
2015年 | 124篇 |
2014年 | 129篇 |
2013年 | 204篇 |
2012年 | 359篇 |
2011年 | 385篇 |
2010年 | 199篇 |
2009年 | 171篇 |
2008年 | 305篇 |
2007年 | 309篇 |
2006年 | 315篇 |
2005年 | 301篇 |
2004年 | 270篇 |
2003年 | 246篇 |
2002年 | 292篇 |
2001年 | 93篇 |
2000年 | 89篇 |
1999年 | 98篇 |
1998年 | 69篇 |
1997年 | 60篇 |
1996年 | 43篇 |
1995年 | 41篇 |
1994年 | 25篇 |
1993年 | 24篇 |
1992年 | 49篇 |
1991年 | 47篇 |
1990年 | 34篇 |
1989年 | 34篇 |
1988年 | 37篇 |
1987年 | 33篇 |
1986年 | 36篇 |
1985年 | 24篇 |
1984年 | 24篇 |
1983年 | 22篇 |
1980年 | 10篇 |
1979年 | 10篇 |
1978年 | 19篇 |
1974年 | 10篇 |
1973年 | 13篇 |
1970年 | 8篇 |
1969年 | 8篇 |
1968年 | 9篇 |
1966年 | 12篇 |
排序方式: 共有5586条查询结果,搜索用时 15 毫秒
1.
2.
3.
Kentaro Yamasaki Takafumi Ishida Tatsuya Kishino Norio Niikawa 《American journal of medical genetics. Part A》2002,111(3):301-306
We report on a Thai family with dominantly inherited malformation syndrome with upper limb anomalies, short stature, quadricuspid aortic valve, and minor craniofacial anomalies. The affected individuals comprised a mildly affected mother, a moderately affected daughter, and a most severely affected son. The daughter and son had short stature. The craniofacial abnormalities comprised frontal bossing, hypoplastic nasal bones, depressed nasal bridge, and broad nasal alae. The upper limb defects varies among the patients, ranging from radial ray defects in the mother through radial and ulnar ray defects with unilateral humeral hypoplasia in the daughter to radial ray defects with severe oligodactyly and bilateral humeral hypoplasia in the son. All patients in this family had hypoplasia of the shoulder girdle and resembled what is observed in many families with Holt‐Oram syndrome. Moreover, the son showed quadricuspid aortic valve with mild aortic regurgitation. However, the present family did not show any mutation of the TBX5 gene, a disease‐causing gene of Holt‐Oram syndrome. The present family deserves further investigation on other genes that play a role in the development of the upper limbs, particularly of radial rays. © 2002 Wiley‐Liss, Inc. 相似文献
4.
Met-RANTES ameliorates fibrous airway obliteration and decreases ERK expression in a murine model of bronchiolitis obliterans. 总被引:1,自引:0,他引:1
Osamu Uchida Naohiro Kajiwara Aeru Hayashi Kuniharu Miyajima Takayoshi Nagatsuka Hiroki Hayashi Masahiro Taira Masakazu Kimura Masahiro Tsuboi Harubumi Kato 《Annals of thoracic and cardiovascular surgery》2007,13(2):82-86
OBJECTIVES: Bronchiolitis obliterans (BO) is the main cause of late mortality among long-term survivors of lung transplantation. Chemokine-chemokine receptor (CCR) interaction and subsequent recruitment of infiltrating cells to the graft are early events in the development of chronic rejection of transplanted lungs. The present study investigated whether blockade of chemokine receptors CCR1 and CCR5 with Met-regulated-on-activation, normal T cells expressed and secreted (RANTES), an amino-terminal modified derivative of RANTES/CCL5, affects the development of BO in murine model and we sought to determine the expression of RANTES/CCL5 and their relationship with extracellular signal-regulated kinase (ERK). Materials and Methods: BALB/c mouse tracheas were heterotopically transplanted into C57Black6 recipients and treated for 21 days with either Met-RANTES at 20 microg/day or vehicle. Animals were killed at 21 days after transplantation for histologic examination of ERK expression. RESULTS: RANTES/CCL5 was highly expressed in allografts compare to isografts. Met-RANTES treatment ameliorated fibrous airway obliteration in a mouse model of BO and decreased ERK expression. CONCLUSION: Blockade of chemokine receptors by Met-RANTES ameliorated airway obliteration and decreased ERK expression. These findings suggest that chemokine receptors CCR1 and CCR5 play significant roles in the development of chronic rejection and ERK may be a new molecular target for chronic rejection. 相似文献
5.
K Teranishi M Murase M Maeda Y Tomida T Koyama H Sasa T Sone H Tsuboi K Kawaguchi 《Kyobu geka. The Japanese journal of thoracic surgery》1990,43(11):901-903
A case of Beh?et disease associated with aortic valve regurgitation treated with aortic valve replacement is reported. The patient was treated successfully with special surgical techniques for prevention of post operative paravalvular leakage and occurrence of pseudo aneurysm because the patient was under long-term steroid therapy for Beh?et disease. 相似文献
6.
Shigeru Onodera Koji Saito Takafumi Saito Hitoshi Togashi Sumio Kawata Katsuaki Ukai Haruhide Shinzawa 《Nihon Shokakibyo Gakkai zasshi》2007,104(2):213-218
It is well known that long-term infection with Clonorchis sinensis often causes bile duct cancer, usually. It occurs in the intrahepatic bile duct. We encountered a rare case of clonorchiasis complicated with duodenal papillary cancer. The patient was a woman from China. Although clonorchiasis is rarely found in Japan, the promotion of international exchange may increase the number of visitors from endemic areas. Thus we must pay sufficient attention to this disease. Also, we reported that the microplate ELISA technique was useful in the diagnosis of clonorchiasis with high accuracy in this case. 相似文献
7.
Satoru Osuka Shingo Takano Takao Enomoto Eiichi Ishikawa Koji Tsuboi Akira Matsumura 《Child's nervous system》2007,23(8):897-900
Background Although there have been reports dealing with ventricular diverticulum (VD) analyzed by cisternography and computed tomography
(CT), those focusing on magnetic resonance imaging (MRI) or neuroendoscopic findings are rare.
Case report We present a case of noncommunicating hydrocephalus caused by aqueductal stenosis with cystic lesion located in supracerebellar
region. Third ventriculostomy was performed on this case. The conventional CT and MRI were compatible with usual VD, but neuroendoscopic
examination suggested otherwise. The endoscopic view inside of the cystic lesion demonstrated passing veins and no membrane.
We diagnosed this cystic lesion as a unique subtype of advanced VD mimicking spontaneous ventriculostomy. Endoscopic observation
of the cyst was very useful for accurate diagnosis and safe treatment. 相似文献
8.
9.
Yukata Okita M.D. Shigehito Miki M.D. Yuichi Ueda M.D. Takafumi Tahata M.D. Tetsuro Sakai M.D. Katsuhiko Matsuyama M.D. Masahiko Matsumura M.D. 《Journal of cardiac surgery》1994,9(4):433-439
A 6-year-old boy was successfully operated on for double outlet ventricle, common atrioventricular canal with severe valvular regurgitation, right atrial Isomerism, L-loop ventricles, total anomalous pulmonary venous connection, and pulmonary stenosis with hypoplastic left pulmonary artery. The Interventricular rerouting from the left ventricle to the ascending aorta was performed with a spiral patch, the lnteratrlal switching was performed by a Mustard patch, the common atrioventricular orifice was partitioned and valve repair was performed, and an 18-mm valved conduit was inserted between the right ventricle and the pulmonary artery. Although the patient had a small residual ventricular septal defect and pulmonary stenosls, the patient Is alive and well. 相似文献
10.
Ryoji Tsuboi Charles N Okeke Akemi Inoue Masashi Yamazaki Masataro Hiruma Hideoki Ogawa 《Nippon Ishinkin Gakkai Zasshi》2002,43(2):91-93
The diagnosis and choice of treatment for dermatophytoses are usually based on the result of microscopic observation of hyphal elements and culture. However, false negative cultures have sometimes been encountered and appropriate timing of discontinuation of treatment has not been formulated. In this study, we attempted the identification and viability assessment of dermatophytes based on the quantitative measurement of dermatophyte actin (ACT) mRNA. An internal fragment of the ACT, 725 to 762 bp, was isolated by PCR from the genomic DNA of dermatophytes and sequenced. ACT intron-based primers were dermatophyte species-specific and primer pairs crossing the intron were dermatophyte genus-specific. The LightCycler (LC) instrument, employing the two-step RT-PCR/fluorescent hybridization system, was used to quantify the actin mRNA (ACT) of dermatophytes. A 669 bp ACT cDNA fragment was used as a quantification standard. Several mg of samples were collected from skin scales or nail plates before and after the treatment using oral terbinafine. The results indicated that quantification of ACT mRNA correlated with the results of culture and KOH examination and that copy numbers of dermatophyte ACT mRNA per mg sample decreased with progression of the therapy. This method comprises a sensitive (1 fg), specific, rapid (< 4 h) and quantitative assessment of the viability and identification of dermatophytes in skin tissue. 相似文献