全文获取类型
收费全文 | 3115篇 |
免费 | 133篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 65篇 |
儿科学 | 24篇 |
妇产科学 | 99篇 |
基础医学 | 543篇 |
口腔科学 | 73篇 |
临床医学 | 187篇 |
内科学 | 650篇 |
皮肤病学 | 10篇 |
神经病学 | 221篇 |
特种医学 | 152篇 |
外科学 | 600篇 |
综合类 | 17篇 |
预防医学 | 45篇 |
眼科学 | 17篇 |
药学 | 195篇 |
中国医学 | 8篇 |
肿瘤学 | 355篇 |
出版年
2023年 | 10篇 |
2022年 | 24篇 |
2021年 | 51篇 |
2020年 | 32篇 |
2019年 | 38篇 |
2018年 | 48篇 |
2017年 | 33篇 |
2016年 | 37篇 |
2015年 | 34篇 |
2014年 | 45篇 |
2013年 | 94篇 |
2012年 | 148篇 |
2011年 | 143篇 |
2010年 | 94篇 |
2009年 | 72篇 |
2008年 | 94篇 |
2007年 | 119篇 |
2006年 | 109篇 |
2005年 | 145篇 |
2004年 | 122篇 |
2003年 | 128篇 |
2002年 | 142篇 |
2001年 | 133篇 |
2000年 | 153篇 |
1999年 | 133篇 |
1998年 | 48篇 |
1997年 | 36篇 |
1996年 | 33篇 |
1995年 | 43篇 |
1994年 | 26篇 |
1993年 | 24篇 |
1992年 | 111篇 |
1991年 | 99篇 |
1990年 | 90篇 |
1989年 | 102篇 |
1988年 | 101篇 |
1987年 | 60篇 |
1986年 | 43篇 |
1985年 | 53篇 |
1984年 | 24篇 |
1983年 | 19篇 |
1982年 | 12篇 |
1979年 | 13篇 |
1978年 | 12篇 |
1977年 | 12篇 |
1973年 | 12篇 |
1972年 | 10篇 |
1969年 | 11篇 |
1967年 | 14篇 |
1966年 | 12篇 |
排序方式: 共有3261条查询结果,搜索用时 0 毫秒
1.
2.
Kazushi Kishi Taizo Takeuchi Tetsuo Sonomura Masashi Kimura Keisuke Kita Morio Sato Masaki Terada 《Cardiovascular and interventional radiology》1997,20(1):63-66
In order to treat fistulated esophageal cancer using a flexible stent, a covered flexible stent was constructed by wrapping
a nitinol stent with a thin sheet of Gore-Tex, preserving the stents original advantages of flexibility and a low-profile
introducer system. This stent was used to perform standard radiotherapy in a case of fistulated esophageal cancer. 相似文献
3.
Y Shimoyama H Suma Y Wanibuchi T Takayama Y Terada Y Fukuda T Saito S Furuta 《Kyobu geka. The Japanese journal of thoracic surgery》1990,43(12):985-987
Coronary artery bypass grafting with combined arterial graft using the left internal mammary artery (IMA), right IMA, and the right gastroepiploic artery (GEA) was performed in 45 patients with saphenous vein graft (SVG) (29 patients) or without SVG (16 patients) from February 1989 to October 1989. The left IMA was used in all patients, the right IMA was used in 9 patients, and the GEA was used in 43 patients. Perioperative myocardial infarction was noted in two patients who had hospital deaths. Reopening the chest for postoperative bleeding was performed in two patients, and the cerebral accident was noted in one patient. Fourteen patients were operated on without the requirement for blood transfusion. Studied within 3 postoperative months, all arterial grafts were patent though the patency was 97.7% (43/44) in SVG. It is concluded that the combined arterial graft utilizing the IMAs and GEA can be used safely and effectively. 相似文献
4.
N-acetylaspartate is an axon-specific marker of mature white matter in vivo: a biochemical and immunohistochemical study on the rat optic nerve. 总被引:5,自引:0,他引:5
Carl Bjartmar Jan Battistuta Nobuo Terada Erica Dupree Bruce D Trapp 《Annals of neurology》2002,51(1):51-58
Axonal pathology is a major cause of neurological disability in multiple sclerosis. Axonal transection begins at disease onset but remains clinically silent because of compensatory brain mechanisms. Noninvasive surrogate markers for axonal injury are therefore essential to monitor cumulative disease burden in vivo. The neuronal compound N-acetylaspartate, as measured by magnetic resonance spectroscopy, is currently the best and most specific noninvasive marker of axonal pathology in multiple sclerosis. The possibility has been raised, however, that N-acetylaspartate is expressed also by oligodendroglial lineage cells. In order to investigate N-acetylaspartate specificity for white matter axons, transected rat optic nerves were analyzed by high-performance liquid chromatography and immunohistochemistry. In transected adult nerves, N-acetylaspartate and N-acetyl aspartylglutamate decreased in concordance with axonal degeneration and were undetectable 24 days posttransection. Nonproliferating oligodendrocyte progenitor cells, oligodendrocytes, and myelin were abundant in these axon-free nerves. At 24 days posttransection, N-acetylaspartate was increased (42%; p = 0.02) in nontransected contralateral nerves. After transection at postnatal day 4, total N-acetylaspartate decreased by 80% (P14; p = 0.002) and 94% (P20; p = 0.003). In these developing axon-free nerves, 25 to 33% of oligodendrocyte progenitor cells were proliferating. These data validate magnetic resonance spectroscopy measurements of N-acetylaspartate as an axon-specific monitor of central nervous system white matter in vivo. In addition, the results indicate that neuronal adaptation can increase N-acetylaspartate levels, and that 5 to 20% of the N-acetylaspartate in developing white matter is synthesized by proliferating oligodendrocyte progenitor cells. 相似文献
5.
N Morikawa K Higuchi T Tsukamoto M Nakano H Terada 《Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan》1989,109(11):858-864
Denopamine (DP) is a new, orally active, selectively positive inotropic agent and used for the treatment of chronic cardiac insufficiency. The therapeutic effects of DP is highly related to its serum concentrations. A simple analytical method has been developed to determine the serum concentration of DP by use of high performance liquid chromatography (HPLC) with electrochemical detection (ECD). In order to extract the DP from the serum, a disposable solid extraction column (Sep-Pak cartridge, C-18) was used. The average recovery was 84.6 +/- 2.7%. The working electrode potential was fixed at 400 mV with a T1 cell, 600 mV with a T2 cell and 650 mV with a Guard cell in ECD. The analysis was performed on a Nova-Pak cartridge C-18 reverse-phase column (100 mm X 8 mm i.d., 4 microns). The mobile phase consisted of 0.1 M potassium phosphate buffer (pH 6.0) and acetonitrile (83: 17, v/v), and the flow rate was 1.0 ml/min. DP and internal standard phenolphthalein (PP) were eluted at 16.5 and 36.0 min, respectively. The peak-height ratio of DP to PP was linearly correlated (r = 0.9998) over a concentrations range between 1.25 and 15.0 ng/ml in the serum. The lowest detectable concentration was 1.0 ng/ml in the serum. The coefficient of variation of reproducibility in the assay was 6.0% By using the present method, serum concentration of DP was measured for four healthy volunteers after a single oral administration of 10 mg DP tablet after a overnight fast. From these DP concentration profiles, pharmacokinetic parameters were calculated.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
6.
The current study investigates the effect of megestrol acetate, a synthetic progestin, on the activity of interleukin-1. Murine thymocytes were suspended in vitro and stimulated with varying concentrations of interleukin-1. [3H]Thymidine uptake was observed as an index of thymocyte proliferation. A dose-dependent increase in [3H]thymidine uptake was observed with increasing concentrations of interleukin-1. When megestrol acetate was added to the solution, a marked suppressive effect was observed. Higher doses of megestrol acetate had a greater suppressive effect on thymocyte proliferation. Additional investigation is required to further delineate the potential systemic effects of megestrol acetate. 相似文献
7.
T. Terada H. Matsumoto Y. Nakamura Y. Kinoshita E. Nakai K. Nakai T. Itakura 《Neuroradiology》1996,38(7):615-617
A transjugular snare technique was used to retrieve a stretched, residual mechanical detachable coil which extended from
the cavernous sinus to the femoral vein, obliterating the transpetrosal route for further embolisation. The coil was snared
by a microguidewire. Our new technique is described in this paper.
Received: 19 April 1995 Accepted: 31 July 1995 相似文献
8.
A Konno N Terada Y Okamoto 《ORL; journal for oto-rhino-laryngology and its related specialties》1987,49(4):206-213
To investigate the responses of nasal vessels, divided into resistance and capacitance vessels, to a beta-receptor agonist in human, mucosal blood flow of the inferior turbinate and nasal airway resistance were measured when 1.5 mg terbutaline was applied topically. Mucosal blood flow was measured by the hydrogen clearance method just beneath the site where terbutaline in physiological saline (0.02 ml) was applied on an extremely localized area of the nasal mucosa. Nasal airway resistance of the ipsilateral and contralateral nasal cavities was measured separately by anterior rhinomanometry when terbutaline in normal saline (0.1 ml) was sprayed in the unilateral nasal cavity. Topical application of terbutaline elicited neither a significant increase of mucosal blood flow of the inferior turbinate nor an increase of nasal airway resistance. beta-Receptors seem not to be as densely distributed both in the resistance vessels and in the capacitance vessels as to cause vasodilatation by their activation in the nasal mucosa. 相似文献
9.
10.
T. Terada K. Miyamoto G. Hyotani M. Tsuura Y. Nakamura T. Nishiguchi T. Itakura S. Hayashi N. Komai 《Acta neurochirurgica》1992,118(3-4):108-111
Summary Changes in tumour blood flow under an induced hypertensive state were examined in malignant brain tumours to know if the precondition for the effectiveness of induced hypertensive chemotherapy — relative increase in tumour blood flow — are fulfilled. Tumour blood flow was measured under both a resting and an induced hypertensive state in 12 patients with various malignant brain tumours (6 gliomas, 6 metastatic brain tumours) using xenon-enhanced computed tomography. The blood pressure was elevated 40% above the systemic blood pressure of the resting state by the infusion of angiotensin II. Tumour blood flow increased 30% on average above the normal brain tissue blood flow after the induction of an induced hypertensive state (p < 0.05). The tumour blood flow increased in 11 cases of malignant tumours, but decreased in one case with massive brain oedema after induced hypertension. The increase in blood flow was higher in hypervascular tumours and less in hypovascular tumours. Therefore, induced hypertensive chemotherapy probably will be more effective in hypervascular malignant brain tumours with small mass effects. 相似文献