全文获取类型
收费全文 | 3282篇 |
免费 | 199篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 66篇 |
妇产科学 | 93篇 |
基础医学 | 753篇 |
口腔科学 | 24篇 |
临床医学 | 273篇 |
内科学 | 657篇 |
皮肤病学 | 29篇 |
神经病学 | 250篇 |
特种医学 | 86篇 |
外科学 | 205篇 |
综合类 | 12篇 |
一般理论 | 2篇 |
预防医学 | 203篇 |
眼科学 | 38篇 |
药学 | 544篇 |
2篇 | |
中国医学 | 11篇 |
肿瘤学 | 228篇 |
出版年
2023年 | 28篇 |
2022年 | 72篇 |
2021年 | 104篇 |
2020年 | 73篇 |
2019年 | 92篇 |
2018年 | 104篇 |
2017年 | 77篇 |
2016年 | 79篇 |
2015年 | 94篇 |
2014年 | 136篇 |
2013年 | 160篇 |
2012年 | 241篇 |
2011年 | 243篇 |
2010年 | 135篇 |
2009年 | 110篇 |
2008年 | 237篇 |
2007年 | 251篇 |
2006年 | 193篇 |
2005年 | 192篇 |
2004年 | 161篇 |
2003年 | 137篇 |
2002年 | 132篇 |
2001年 | 27篇 |
2000年 | 14篇 |
1999年 | 34篇 |
1998年 | 27篇 |
1997年 | 22篇 |
1996年 | 46篇 |
1995年 | 12篇 |
1994年 | 7篇 |
1993年 | 8篇 |
1992年 | 11篇 |
1991年 | 16篇 |
1990年 | 22篇 |
1989年 | 22篇 |
1988年 | 15篇 |
1987年 | 16篇 |
1986年 | 14篇 |
1985年 | 17篇 |
1984年 | 8篇 |
1983年 | 9篇 |
1981年 | 10篇 |
1980年 | 10篇 |
1979年 | 8篇 |
1977年 | 5篇 |
1974年 | 4篇 |
1973年 | 5篇 |
1972年 | 10篇 |
1970年 | 8篇 |
1968年 | 4篇 |
排序方式: 共有3488条查询结果,搜索用时 15 毫秒
1.
Jeroen M. van de Pol Jurjen G. Geljon Svetlana V. Belitser Geert W.J. Frederix Anke M. Hövels Marcel L. Bouvy 《Research in social & administrative pharmacy》2019,15(1):70-76
Introduction
The nature of community pharmacy is changing, shifting from the preparation and distribution of medicines to the provision of cognitive pharmaceutical services (CPS); however, often the provision of traditional services leaves little time for innovative services. This study investigated the time community pharmacists spend on the tasks and activities of daily practice and to what extent they are able to implement CPS-related services in daily practice.Methods
Self-reporting work sampling was used to register the activities of community pharmacists. A smartphone application, designed specifically for this purpose, alerted participants to register their current activity five times per working day for 6 weeks. Participants also completed an online survey about baseline characteristics.Results
Ninety-one Dutch community pharmacists provided work-sampling data (7848 registered activities). Overall, 51.5% of their time was spent on professional activities, 35.4% on semi-professional activities, and 13.1% on non-professional activities. The proportion of time devoted to CPS decreased during the workweek, whereas the time spent on traditional task increased.Discussion and conclusion
This study shows it is feasible to collect work-sampling data using smartphone technology. Community pharmacists spent almost half of their time on semi-professional and non-professional activities, activities that could be delegated to other staff members. In practice, the transition to CPS is hampered by competing traditional tasks, which prevents community pharmacists from profiling themselves as pharmaceutical experts in daily practice. 相似文献2.
3.
4.
Morin Catherine L.; Dolina Svetlana; Robertson Richard T.; Ribak Charles E. 《Cerebral cortex (New York, N.Y. : 1991)》1994,4(2):119-128
BALB/c mice lack a corpus callosum in about 11% of the population.Two inbred substrains of BALB/c mice, epilepsy-prone (EP) andepilepsy-resistant (ER), have been examined to determine whetherthese substrains differ in regard to corpus callosum morphology.Further, this study addressed the issue of whether misroutedcortical axons form an aberrant pathway instead of the corpuscallosum. Initial studies that examined fresh brain tissue ofadult animals revealed normal corpora callosa in all ER micebut deficient or absent corpora callosa in all EP mice. Subsequently,Dil crystals were placed in the motor cortices of aldehyde-fixedbrains of 2-week-old animals to investigate cortical projectionsin both inbred substrains of mice. Fluorescent microscopy revealedthat all of the ER animals had normal corpora callosa, whereasall EP animals exhibited either reduced corpora callosa (partiallycallosal) or an absence (acallosal) of this structure. Bothacallosal and partially callosal EP mice displayed an extensive,aberrant projection to the basal forebrain as well as bilateralprojections to midline and intralaminar thalamic nuclei. Thefibers projecting to the basal forebrain arose from the cortex,coursed toward the midline before turning ventrally along themidline, and appeared to terminate in the medial septal nucleusand the nucleus of the diagonal band. ER animals lacked thisaberrant cortical projection to the basal forebrain. Electronmicroscopic results obtained from EP mice indicated that labeledaxons in this aberrant pathway formed axosomatic, axodendritic,and axospinous synapses with the neurons in the medial septal/diagonalband complex. The function of the aberrant projection to thebasal forebrain remains unknown but it may provide an abnormalexcitatory input to a region that provides cholinergic and GABAergicinput to the cerebral cortex and hippocampus. The additionalprojections to midline and contralateral intralaminar thalamicnuclei in EP mice may function to intensify the synchronizationof bilateral discharges. 相似文献
5.
V. L. Gein N. N. Kasimova M. A. Panina É. V. Voronina 《Pharmaceutical Chemistry Journal》2006,40(8):410-412
A series of l-(5-aryl-4-benzoyl-3-hydroxy-2-oxo-3-pyrrolin-l-yl)-2-(3-benzoylmethylene-2-oxopiperazin-1-yl)ethanes have been
obtained with 35–37% yields via reactions of benzoylpyruvic acid methyl ester with a mixture of aromatic aldehyde and diethylenetriamine
in a 2: 1: 1 molar ratio.
__________
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 8, pp. 5–6, August, 2006. 相似文献
6.
G. M. Molodavkin E. B. Burlakova L. I. Chernyavskaya T. A. Voronina N. I. Khorseva S. B. Seredenin 《Bulletin of experimental biology and medicine》1996,121(2):151-153
Benzodiazepine tranquilizers, phenazepam and flunitrazepam, administered to random-bred albino male rats in superlow doses
(10−9–10−15 mol/kg), are shown to exert an anxiolytic effect in the conflict test. In contrast to the case with the usual doses, the
above effect is not accompanied by marked myorelaxant or sedative effects.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, № 2, pp. 164–166, February, 1996 相似文献
7.
Alexey V. Mazurov Dimitry V. Vinogradov Svetlana G. Khaspekova Anatoly V. Krushinsky Ludmila V. Gerdeva Sergei A. Vasiliev 《European journal of haematology》1996,57(1):38-41
Abstract: Patient B.G. is a 29-yr-old female with a lifelong bleeding disorder characterized clinically by a highly increased bleeding time, menorrhagias, long-lasting bleeding after cuts and tooth extractions and large post-traumatic haematomas. Her coagulation tests were within normal range, platelet count was 140,000–160,000 per μl, but platelet function was impaired as demonstrated by the absence of collagen-induced aggregation, although no abnormalities were detected in aggregation response to ADP and ristocetin. Morphologically her platelets were characterized by gigantic size – average profile area was about 2.5 times higher than that of control donors, and severe deficiency of α-granules – only 16% of their number in control donors. These features taken together indicated the diagnosis of grey platelet syndrome. As has been shown by quantitative immunoblotting, patient's platelets contained small amounts of α-granule membrane protein P-selectin – about 15% of that in control donors. The content of plasma membrane glycoproteins IIb–IIIa and Ib was not reduced, suggesting the specific deficiency of α-granule membrane protein. Thus, B.G. is the second patient described in the literature (see also Lages et al, J Clin Invest 1991: 87: 919–929) with combined deficiency of α-granules and P-selectin. 相似文献
8.
Ljiljana Ševaljević Sanja Marinković Desanka Bogojević Svetlana Matić Bogdan Bošković 《Archives of toxicology》1989,63(5):406-411
We have studied the effect of soman intoxication on serum acute phase reactants (APR) levels, and the relationship of the APR and corticosterone concentrations and the immunosuppressive activity of the serum. One day after the injection of 1.8 LD50 soman the concentrations of 2-macroglobulin (2-MG) and 1-acid glycoprotein (AGP) in the serum of antidote protected rats increased 4- and 7-fold, respectively, whereas those of hemopexin (Hx), haptoglobin (Hp) and cysteine protease inhibitor (CPI) were two to three times higher than in the controls. A similar magnitude of increase of serum acute phase reactants levels was observed when 0.3 LD50 soman was administered at 24-h intervals over the 5-day period. The relationship of changes in the APR concentration, corticosterone level and immunosuppressive activity of the serum was also comparable to that observed in the acute phase response to tissue injury. 相似文献
9.
10.
Yellow fever (YF) is a zoonotic infection with more than 200,000 cases reported annually. Relatively little is known about YF pathogenesis in humans. In this study, we demonstrate that human vascular endothelial cells are susceptible to infection with wild-type and vaccine strains of the YFV and that these infections lead to a differential cellular response to infection. The infection of endothelial cells with either virus resulted in a significant induction of interferon-inducible genes p 78 and Cig 5 while wild-type virus induced a much more pronounced IL 6 and Bc l2 response than did the vaccine strain. Both viruses induced RANTES gene expression, but only the wild-type virus had corresponding increases in RANTES protein expression. The results demonstrate that the wild-type and vaccine strains of YFV elicit significantly different responses to infection in endothelial cells, despite being nearly identical genetically. These differences may account for the attenuated phenotype of the YFV vaccine strain, though the mechanism remains unclear. These data also point to a role for vascular endothelial cells in YF hemorrhagic fever and also suggest that IL 6 may play a role in increased viral pathogenesis, perhaps by influencing coagulation via release of coagulation co-factors such as fibrin or fibrinogen. 相似文献