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Torti C Quiros-Roldan E Monno L Patroni A Saracino A Angarano G Tinelli C Lo Caputo S Tirelli V Mazzotta F Carosi G;MASTER Cohort GenPheRex Study Group;MASTER Cohort PhenGen Study Group 《Journal of medical virology》2004,74(1):29-33
This study aimed at identifying HIV-1 protease amino acid changes associated with protease inhibitor (PI) exposure and susceptibility. New amino acid substitutions were correlated with the number of experienced PIs, reaching statistical significance only for those at positions 3, 44, and 74. The correspondence multivariate model demonstrated that > or =3 experienced PIs and substitutions or mutations at positions 3, 46, 54, 73, 74, and 84 were correlated with PI cross-resistance, including resistance for lopinavir and amprenavir in this cohort of patients who were naive for these drugs. 相似文献
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Lipid abnormalities in HIV-infected patients are not correlated with lopinavir plasma concentrations
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Analysis of human papillomavirus prevalence and TP53 polymorphism in head and neck squamous cell carcinomas 总被引:1,自引:0,他引:1
Cortezzi SS Provazzi PJ Sobrinho JS Mann-Prado JC Reis PM de Freitas SE Filho JF Fukuyama EE Cordeiro JA Cury PM Maniglia JV Villa LL Tajara EH Rahal P 《Cancer Genetics and Cytogenetics》2004,150(1):44-49
Head and neck squamous cell carcinoma is a disease associated with tobacco and alcohol abuse. There is evidence that the oncogenic human papillomavirus (HPV) may also be a risk for upper aerodigestive tract cancers. High-risk HPVs encode two early proteins, E6 and E7, that can bind to p53 and pRb, respectively, and induce its degradation or inactivation. The TP53 gene has a single polymorphism at codon 72 of exon 4 that encodes either arginine (Arg) or proline (Pro). The purpose of this study was to evaluate the role of HPV infection and TP53 polymorphism in head and neck cancer. We analyzed 50 tumors, as well swabs of oral mucosa from 142 control individuals, with a polymerase chain reaction technique. The prevalence of HPV in controls was 10.6% and in cancer specimens 16%. The frequency distribution of genotypes in controls was 50% Arg/Arg, 43% Arg/Pro and 7% Pro/Pro; in tumors, it was 52% Arg/Arg, 32% Arg/Pro, and 16% Pro/Pro. Contrary to the results of some studies on cervical cancer, no association between any TP53 genotype or allele and the development of head and neck cancer was observed, regardless of HPV status, except for the Pro/Pro genotype, which is associated with the absence of HPV. The arginine allele appears to protect against head and neck cancers. Also, the data showed that HPV infection results in no increased risk of developing head and neck tumors. 相似文献
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Michaela Day Rachel Pitt Nisha Mody John Saunders Rupa Rai Achyuta Nori Hannah Church Sarah Mensforth Helen Corkin Jacqueline Jones Preneshni Naicker Wazirzada M Khan Rebecca Thomson Glover Kalani Mortimer Chloe Hylton Elizabeth Moss Thomas Joshua Pasvol Ania Richardson Suzy Sun Neil Woodford Hamish Mohammed Katy Sinka Helen Fifer 《Euro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin》2022,27(46)
Between December 2021 and June 2022, 10 cases of ceftriaxone-resistant Neisseria gonorrhoeae (ST8123; n = 8) were detected in the United Kingdom, compared with nine cases during the previous 6 years. Most of these cases were associated with travel from the Asia-Pacific region; all were heterosexual people, with most in their 20s. Although all cases were successfully treated, not all partners of cases could be traced, and there is a risk of further transmission of ceftriaxone-resistant gonococcal infection within the UK. 相似文献
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Abnormalities in nitric oxide and its derivatives in lung cancer 总被引:1,自引:0,他引:1
Masri FA Comhair SA Koeck T Xu W Janocha A Ghosh S Dweik RA Golish J Kinter M Stuehr DJ Erzurum SC Aulak KS 《American journal of respiratory and critical care medicine》2005,172(5):597-605
RATIONALE: A cellular prooxidant state promotes cells to neoplastic growth, in part because of modification of proteins and their functions. Reactive nitrogen species formed from nitric oxide (NO) or its metabolites, can lead to protein tyrosine nitration, which is elevated in lung cancer. OBJECTIVE: To determine the alteration in these NO derivatives and the role they may play in contributing to lung carcinogenesis. METHODS: We analyzed levels of NO, nitrite (NO2-), nitrate (NO3-), and the location of the protein nitration and identified the proteins that are modified. MEASUREMENTS AND MAIN RESULTS: Although exhaled NO and NO2- were increased, endothelial NO synthase or inducible NO synthase expression was similar in the tumor and tumor-free regions. However, immunohistochemistry showed that nitrotyrosine was increased in the tumor relative to non-tumor-bearing sections. We used proteomics to identify the modified proteins (two-dimensional polyacrylamide gel electrophoresis; mass spectrometry). Both the degree of nitration and the protein nitration profile were altered. We identified more than 25 nitrated proteins, including metabolic enzymes, structural proteins, and proteins involved in prevention of oxidative damage. Alterations of the biology of NO metabolites and nitration of proteins may contribute to the mutagenic processes and promote carcinogenesis. CONCLUSIONS: This study provides evidence in favor of a role for reactive nitrogen and oxygen species in lung cancer. 相似文献