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排序方式: 共有266条查询结果,搜索用时 15 毫秒
1.
Mukhopadhyay S Mukhopadhyay S Banki K Mahajan S 《Archives of pathology & laboratory medicine》2004,128(12):1445-1447
We report on 2 patients who were initially suspected to have classic Hodgkin lymphoma because of lymphadenopathy and the presence of Reed-Sternberg-like cells. Both patients had an associated leukemoid reaction (using a threshold leukocyte count of 50 000/microL) and were eventually diagnosed with metastatic carcinoma. Disseminated carcinoma can mimic Hodgkin lymphoma clinically, radiologically, and histologically. Reed-Sternberg-like cells may be found in carcinomas, and they represent a particularly challenging diagnostic pitfall for the unwary. When these cells lead to a suspicion of Hodgkin lymphoma, the presence of a leukemoid reaction should prompt the pathologist to question the diagnosis. Misdiagnosis can be avoided by the use of cytokeratin whenever a leukemoid reaction is present in a suspected case of Hodgkin lymphoma. 相似文献
2.
The sister chromatid exchange (SCE) incidence and growth kinetics have been studied by means of an in vitro bromodeoxyuridine (BrdU) chromosome labeling method in the bone marrow cells of 17 acute myeloblastic leukemia (AML) patients with only diploid cells at diagnosis, remission, and relapse of the disease. At diagnosis, the cells tended to exhibit a low SCE frequency as compared to that during remission. An increased SCE frequency was observed after chemotherapy during remission or relapse. At diagnosis and relapse, when leukemic blast cells predominated in the marrow, they were characterized by the predominance of cells that had undergone only one cell cycle after BrdU exposure. In contrast, the marrow cells during remission tended to resemble the control pattern of growth kinetics, with a predominance of cells undergoing second and third cell cycles in the presence of BrdU. These results suggest that the growth rate of leukemic and nonleukemic cells is different, and that chemotherapy can cause an increased SCE frequency in the marrow cells of AML patients irrespective of the state of the disease. 相似文献
3.
The present contribution deals with the histochemical mapping of the distribution of acid and alkaline phosphatases and succinic dehydrogenase in the medulla oblongata and spinal cord of mouse. The acid phosphatase is observed in neurons of all the nuclei except nucleus cervicalis lateralis (NC), though the activity varies from intense to moderate. Only one nucleus, i.e., nucleus parvocellularis compactus (NPC) is midly positive. In alkaline phosphatase preparations most of the nuclei are either intensely positive or moderately positive. Few nuclei are midly positive. It is interesting to note that only two nuclei, i.e., area postrema (AP) and nucleus cervicalis lateralis (NC) are negative for this enzyme. Further the reaction in most of the nuclei is diffused. In the case of succinic dehydrogenase out of 36 nuclei studied, 9 nuclei are intensely positive, 11 areas are moderately positive, 7 are mildly positive and 9 are completely devoid of enzymatic activity. Nucleus reticularis superior demonstrates activity of very high order. The distribution of the above enzyme has been co-related with the functional significance of the various nuclei. 相似文献
4.
Meenakshi Lallar Haq ul Anam Rajesh Nandal Sunder Pal Singh Surabhi Katyal 《Journal of obstetrics and gynaecology of India》2015,65(1):17-22
Objectives
To compare intravenous paracetamol and intramuscular tramadol as labor analgesics.Methods
This prospective-randomized study conducted in 200 primigravidae in active labor, distributed into two groups of 100 women each with one receiving intravenous 1,000 mg Paracetamol and other 100 mg intramuscular tramadol. Pain intensity is recorded by McGills scale before, one and 3 h after drug administration. Perinatal outcome is recorded.Results
No difference in pain intensity is seen before drug administration. After 1 h of drug administration, in paracetamol group, 4 % women had horrible pain, and 29 % had distressing pain, while in tramadol group, 30 % women had horrible pain, and 60 % had distressing pain. After 3 h of drug administration, in paracetamol group, 26 % had distressing pain, while in tramadol group, 51 % women had horrible pain, and 35 % had distressing pain. Labor duration in paracetamol and tramadol group was 4.3 and 5.9 h, respectively. In paracetamol group, nausea is seen in 2.2 % and vomiting in 1.1 %, while in tramadol group, nausea is seen in 6.4 % and vomiting in 4.3 %.Conclusions
Intravenous paracetamol is more effective labor analgesic with fewer maternal adverse effects and shortens labor as compared to intramuscular tramadol.5.
Kosuke Izumi Avni B. Santani Matthew A. Deardorff Holly A. Feret Tanya Tischler Brian D. Thiel Surabhi Mulchandani Catherine A. Stolle Nancy B. Spinner Elaine H. Zackai Laura K. Conlin 《American journal of medical genetics. Part A》2013,161(1):166-171
Prader–Willi syndrome is caused by the loss of paternal gene expression on 15q11.2–q13.2, and one of the mechanisms resulting in Prader–Willi syndrome phenotype is maternal uniparental disomy of chromosome 15. Various mechanisms including trisomy rescue, monosomy rescue, and post fertilization errors can lead to uniparental disomy, and its mechanism can be inferred from the pattern of uniparental hetero and isodisomy. Detection of a mosaic cell line provides a unique opportunity to understand the mechanism of uniparental disomy; however, mosaic uniparental disomy is a rare finding in patients with Prader–Willi syndrome. We report on two infants with Prader–Willi syndrome caused by mosaic maternal uniparental disomy 15. Patient 1 has mosaic uniparental isodisomy of the entire chromosome 15, and Patient 2 has mosaic uniparental mixed iso/heterodisomy 15. Genome‐wide single‐nucleotide polymorphism array was able to demonstrate the presence of chromosomally normal cell line in the Patient 1 and trisomic cell line in Patient 2, and provide the evidence that post‐fertilization error and trisomy rescue as a mechanism of uniparental disomy in each case, respectively. Given its ability of detecting small percent mosaicism as well as its capability of identifying the loss of heterozygosity of chromosomal regions, genome‐wide single‐nucleotide polymorphism array should be utilized as an adjunct to the standard methylation analysis in the evaluation of Prader–Willi syndrome. © 2012 Wiley Periodicals, Inc. 相似文献
6.
Malak Itani Ania Kielar Christine O. Menias Manjiri K. Dighe Venkat Surabhi Srinivasa R. Prasad Ryan O’Malley Kiran Gangadhar Neeraj Lalwani 《International urogynecology journal》2016,27(2):195-204
Introduction and hypothesis
Accurate diagnosis of a wide spectrum of urethral/periurethral pathologies in women remains challenging due to its anatomical location and nonspecific clinical presentations. Magnetic resonance imaging (MRI) has emerged as the modality of choice for diagnosing female urethral and periurethral pathologies due to its multiplanar scanning capability, superior soft tissue differentiation, noninvasive nature, and overall excellent contrast resolution.Methods
In this narrative review, we describe the use of MRI to visualize the female urethra and periurethral pathologies.Results
MRI can confidently characterize lesions into cystic or solid, provide a more succinct differential diagnosis, and in some cases provide a specific and accurate diagnosis, enabling surgeons to prepare a roadmap before operative procedure. Moreover, functional MRI can be useful to assess dynamic disorders such as urethral hypermobility.Conclusions
We provide a comprehensive review of normal MR anatomy of the female urethra, as well as the MR features of practically important urethral and periurethral lesions.7.
8.
Srivastava Sharad Tiwari Surabhi Srivastava Nishi Verma Shikhar Rawat Ajay Kumar Singh 《Proceedings of the National Academy of Sciences, India. Section B.》2019,89(3):1057-1066
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences - Centella asiatica (L.) Urb. (Apiaceae) with high commercial value is an important herb in traditional Indian... 相似文献
9.
Recalcitrant hypertrophic herpes genitalis in HIV‐infected patient successfully treated with topical imiquimod 下载免费PDF全文
Herpes Simplex Virus type 2 is the primary cause of genital ulceration worldwide. The presence of atypical features like deep ulcerations, hypertrophic, or pseudotumoural lesions or unusual location can be a marker for co‐infection with HIV. These immunocompromised patients are usually resistant to the conventional antiviral treatment. We present a case of an HIV‐infected patient with hypertrophic herpes genitalis, refractory to conventional oral antiviral therapy, who was successfully treated with a combination of oral valcyclovir and topical application of 5% imiquimod. 相似文献
10.
Satyaswarup Tripathy Arshad H. Khan Surabhi Sharma 《European journal of plastic surgery》2010,33(1):23-28
Defects around the elbow region are often irregular with exposed nerves, tendons, bones/joint, and implants. Skin grafts,
though possible in some cases, must be avoided, as it requires prolonged splintage and physiotherapy to prevent recurrence
and elbow stiffness. Distant flaps require multiple stages, and free flaps are rarely indicated for elbow defects. Muscle
flaps are bulky. To overcome these problems, distally based fasciocutaneous flaps from medial and lateral sides of the arm
based on posterior ulnar recurrent artery and radial recurrent artery, respectively, were used. Ten patients were studied.
Age of the patients ranged from 10 to 40 years. Five were male, and five were female. Radial and ulnar recurrent flaps were
used in five patients each. The largest flap size was 18 × 8 cm, and the smallest was 10 × 6 cm. The flaps were islanded in
four cases, and in six cases, they were used as pedicled flaps. Skin grafts were used in 90% of the patients because large
flaps were required for resurfacing; also, our patients had thinner arms with less girth. All flaps survived well. One island
flap had venous congestion and marginal necrosis, which eventually healed. A significant improvement of mobility and elbow
movement was noted in all patients. These flaps can be raised even from the previously burnt skin, as the pedicle is located
deep. These flaps have the following advantages: The flap is reliable (deeply located consistent vascular pedicle), can cover
both the flexor and extensor surface of the elbow joint, avoids prolonged splintage, elbow stiffness, and recurrence, good
aesthetic, and has functional results. 相似文献