全文获取类型
收费全文 | 656篇 |
免费 | 45篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 20篇 |
妇产科学 | 11篇 |
基础医学 | 51篇 |
口腔科学 | 26篇 |
临床医学 | 53篇 |
内科学 | 126篇 |
皮肤病学 | 158篇 |
神经病学 | 24篇 |
特种医学 | 24篇 |
外科学 | 100篇 |
综合类 | 36篇 |
预防医学 | 24篇 |
眼科学 | 9篇 |
药学 | 25篇 |
中国医学 | 1篇 |
肿瘤学 | 12篇 |
出版年
2023年 | 5篇 |
2022年 | 13篇 |
2021年 | 21篇 |
2020年 | 18篇 |
2019年 | 10篇 |
2018年 | 23篇 |
2017年 | 13篇 |
2016年 | 19篇 |
2015年 | 19篇 |
2014年 | 25篇 |
2013年 | 24篇 |
2012年 | 34篇 |
2011年 | 30篇 |
2010年 | 22篇 |
2009年 | 23篇 |
2008年 | 42篇 |
2007年 | 39篇 |
2006年 | 33篇 |
2005年 | 29篇 |
2004年 | 32篇 |
2003年 | 33篇 |
2002年 | 25篇 |
2001年 | 26篇 |
2000年 | 15篇 |
1999年 | 15篇 |
1998年 | 9篇 |
1997年 | 6篇 |
1996年 | 6篇 |
1995年 | 7篇 |
1993年 | 1篇 |
1992年 | 4篇 |
1991年 | 2篇 |
1990年 | 7篇 |
1989年 | 12篇 |
1988年 | 16篇 |
1987年 | 4篇 |
1986年 | 9篇 |
1985年 | 7篇 |
1984年 | 2篇 |
1983年 | 7篇 |
1982年 | 1篇 |
1981年 | 4篇 |
1980年 | 2篇 |
1978年 | 6篇 |
1977年 | 1篇 |
1972年 | 1篇 |
1970年 | 1篇 |
排序方式: 共有703条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
The prevalence of resistance to six commonly-used antimicrobial agents in faecal coliforms from children in Khartoum, Sudan was studied. A relatively high prevalence of resistance was found, ranging from 96% of children with isolates resistant to ampicillin to 70% of children with isolates resistant to chloramphenicol. Seventy-seven percent of children had isolates with high-level resistance to trimethoprim (MIC greater than 1000 micrograms/ml). Twenty-nine different resistance patterns were found. Thirty-nine percent of the children had isolates resistant to all six antibiotics studied, and 80% of children had isolates resistant to at least four. Transfer of resistance to each of the antimicrobials, in varying combinations, was demonstrated, but did not occur for all resistance patterns. Plasmid analysis showed plasmids ranging from 160 MDa to 2.8 MDa and isolates contained from one to five plasmids of different sizes. There were no consistent relationships between resistance pattern and plasmid profile, but multiple resistance transfer was mediated commonly by plasmids with a molecular weight of 62 MDa. The high prevalence of potentially transferable antibiotic resistance in gut commensals of children in the Sudan may be of importance in the management of enteric and other infections requiring antimicrobial treatment. 相似文献
5.
Mansour Al-Janadi Abdullah Al-Dalaan Suliman Al-Balla Mohammed Al-Humaidi Syed Raziuddin 《Journal of clinical immunology》1996,16(4):198-207
Interleukin-10 (IL-10) is a major immunoregulatory cytokine and has a multitude of immunomodulatory effects in the immune system. In this study, we have examined the secretion andin vitro function of IL-10 in B cell hyperactivity in antibody production in two common autoimmune diseases, systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). IL-10 was detectable in serum of all active SLE and serum and synovial fluid samples of all RA patients but in none of the normal controls. B cells and CD4+CD45RO+ memory T cells secreted highly enhanced levels of IL-10 in SLE and RA versus normals. Increased IgM and IgG production by B cells-CD4+CD45RO+ T cells in SLE and RA was IL-10 dependent, since neutralization of IL-10 cytokine by anti-IL-10 antibody drastically reduced Ig synthesis in these coculture experiments. B cell hyperactivity in autoantibody production in SLE and RA may be a function of IL-10-dependent CD4+CD45RO+ Th2 cell activation. Therefore, IL-10 may play an important role in highly disturbed immune system and B cell-T cell function in these immune disorders. 相似文献
6.
Cytokine profile in systemic lupus erythematosus,rheumatoid arthritis,and other rheumatic diseases 总被引:19,自引:0,他引:19
Mansour Al-Janadi Suliman Al-Balla Abdullah Al-Dalaan Syed Raziuddin 《Journal of clinical immunology》1993,13(1):58-67
We investigated serum levels of interleukin-6 (IL-6), interferon-gamma (IFN-), and tumor necrosis factor alpha (TNF) from patients with systemic lupus erythematosus (SLE) and its various clinical manifestations of disease and from patients with rheumatoid arthritis (RA) and other rheumatic diseases. The serum levels of IL-6 and IFN- were highly elevated from patients with SLE associated with lymphadenopathy (LN) or nephrotic syndrome (NS). On the contrary, the serum levels of TNF were elevated from most patients with SLE associated with thrombocytopenia (TP). However, serum levels of TNF were in the normal range from patients with SLE associated with NS, LN, or central nervous system disease. Of interest, patients with SLE associated with humoral immunodeficiency disorder, hypogammaglobulinemia, had highly elevated levels of serum IL-6. The concanavalin A-stimulated mononuclear cells (MNC) of patients with SLE associated with TP secreted highly elevated levels of TNF compared to other patient groups. We suggest that abnormal production of various cytokines in SLE is an intrinsic defect of MNC and the immune system that may be the key element for a variety of clinical manifestations of this disease. 相似文献
7.
N. McDermott Lecturer Y. Suliman Third Year Medical Student C. Barry Walsh Consultant /Senior Lecturer E. W. Kay Consultant /Senior Lecturer B. Curran Histotechnologist C. Milburn Histotechnologist M. Turner Master / Consultant W. Prendiville Consultant/Professor M. Leader Professor /Consultant 《BJOG : an international journal of obstetrics and gynaecology》1997,104(5):623-625
We have investigated the ploidy profile of morphologically normal mucosa adjacent to high grade CIN ( n = 16 ) and also from normal cervix ( n = 18). DNA ploidy was assessed using flow cytometry and image analysis. All cases were diploid by both modalities. Our results show that morphologically normal squamous mucosa has a stable ploidy profile even when it lies adjacent to high grade CIN. This finding supports the view that high grade CIN is a neoplastic expansion of transformed cells rather than the result of a field change effect. 相似文献
8.
Thaer S. Alomar Khalid Mahmood Simon O’Connor Keith Robson Harminder S. Dua 《International ophthalmology》2013,33(5):561-565
Crystalline corneal deposits have been well reported in individual cases of lymphoproliferative disorders associated with hyper-gammaglobulinemia, hence called ‘Crystalline Paraproteinemic Keratopathy’. This is the first report of corneal deposits in a case of localised conjunctival B-cell Lymphoma without paraproteinaemia/hyper-gammaglobulinemia, hence called ‘Presumed Paraproteinic Crystalline Keratopathy’. 相似文献
9.