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排序方式: 共有92条查询结果,搜索用时 31 毫秒
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Ana Paula Fortes dos Santos Thomazelli Milena Menegazzo Miranda-Sapla Suelen Santos da Silva Daniele Sapede Alvarenga Carolina Panis 《Immunopharmacology and immunotoxicology》2013,35(5):387-392
AbstractThe context of the article: Leishmania amazonensis has a wide geographical distribution throughout South American countries and can cause self-healing to severe cases as mucocutaneous or visceral forms. Leishmaniasis presents a balance of inflammatory and anti-inflammatory cytokines which is responsible for promoting the activation of phagocytes, essential to control the infection and lead to tissue repair/resolution of the disease, respectively.Results and discussion: Our model revealed that the treatment with Con-A was capable to stimulate human PBMC cells by increasing the phagocytic capacity and promoting parasite elimination. The pretreatment with Con-A promoted inflammatory (IFN-γ, TNF-α, IL-2 and IL-6) and anti-inflammatory (IL-4 and IL-10) cytokines production, increased the reactive oxygen species (ROS) sinthesys as well as the expression and presence of iNOS enzyme, but not nitric oxide production.Conclusion: Based on the data obtained, it was possible to infer that Con-A induces the ROS production, responsible for eliminating parasites in addition to regulatory cytokines synthesis which are important for disease resolution. 相似文献
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de Siqueira Fabiana Suelen Figueredo Hilgemberg Bruna Araujo Lucila Cristina Rodrigues Hass Viviane Bandeca Matheus Coelho Gomes João Carlos Reis Alessandra Loguercio Alessandro D Cardenas Andres Felipe Millan 《Clinical oral investigations》2020,24(2):809-822
Clinical Oral Investigations - The aim of this study was to investigate the effects of collagen cross-linking agents on nanomechanical and bonding properties of eroded dentin (ED), 24 h... 相似文献
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Participation of neurofilament proteins in axonal dark degeneration of rat's optic nerves 总被引:2,自引:0,他引:2
Neurofilaments (NF) are neuronal intermediate filaments formed by three different subunits: high (NF-H), medium (NF-M) and light (NF-L). They are responsible for the determination and maintenance of axon caliber. Accumulation of NF or their immunoreactive products are components of several neurodegenerative disease lesions, such as neurofibrillary tangles, Lewy bodies and the spheroids of amyotrophic lateral sclerosis. Also, cytoskeletal breakdown is one of the first ultrastructural changes occurring after nerve crush or section. In the present study, Wistar rats were subjected to bilateral enucleation to induce Wallerian degeneration of optic nerve fibers and perfused 24 h, 48 h and 1 week later. Optic nerve segments were processed for electron microscopy (EM), light microscopy immunofluorescence (LM) and immunoelectronmicroscopy (IEM) for NF subunit detection. LM for NF of control nerves showed a slightly different pattern and intensity for each subunit, with more intense staining of NF-M and NF-H and less intense staining of NF-L. This reaction did not change considerably at 48 h, but was severely reduced 1 week after enucleation. Results of EM showed fibers in: (1) partial cytoskeleton degeneration or (2) watery degeneration or (3) dark degeneration. The number of dark degenerating axons was statistically higher at the latest time-interval studied. Neurofilament clumping areas and dark degenerating axons showed positive immunostaining for the three neurofilaments subunits when examined by IEM. These results suggest that dark degenerating axons develop from areas of neurofilament aggregation. We may also conclude that NF proteins participate in the process of axonal dark degeneration. 相似文献
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Grayson N Soo S Robbé IJ 《Journal of public health medicine》2003,25(3):275; author reply 275-275; author reply 276
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Aldini Beuting Pereira Kitahara Arieli Carini Michels Suelen Teixeira Luiz Seigo Nagashima Ana Paula Camargo Martins Marina Luise Viola de Azevedo Luciana Reis Azevedo Alanis Paulo Henrique Couto Souza Sérgio Aparecido Ignácio Lucia de Noronha Patrícia Vida Cassi Bettega Maria Carolina Albini Tyski Edinson Manuel Pérez Quispe Izabela Mozzer Giovanna Ribeiro Souto Maria Cássia Ferreira Aguiar Filipe Modolo Rafaela Scariot Bruno Correia Jham Ana Maria Trindade Grégio Hardy Aline Cristina Batista Rodrigues Johann 《Oral diseases》2023,29(2):376-379
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G Baumann A Walser P A Desaulles F J Paesi L Geller 《The Journal of clinical endocrinology and metabolism》1976,42(1):60-63
The corticotropic action of a synthetic ACTH derivative, D-Ser1 Lys17,18-1-18ACTH, after intranasal insufflation of 1 mg of the peptide was evaluated in 14 normal volunteers. Plasma cortisol and urinary 17-ketogenic steroids and 17-ketosteroids rose significantly over control values in all subjects (P less than 0.001). Plasma cortisol remained above the normal range for comparable clock times for 18 hr, but fell below 15 mug/100 ml after 12 hr. No evidence for suppression of the hypothalamo-pituitary axis was found the day after ACTH administration, as judged by normal plasma and urinary steroid values and normal diurnal variation. Intranasal administration of long-acting ACTH derivatives may provide a simple, painless and effective way to stimulate endogenous corticosteroid secretion. 相似文献
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Góes SM Leite N Shay BL Homann D Stefanello JM Rodacki AL 《Clinical biomechanics (Bristol, Avon)》2012,27(6):578-583