Intravenous cidofovir treatment for recalcitrant warts in the setting of a patient with myelodysplastic syndrome

Cidofovir is an acyclic nucleoside phosphonate with broad-spectrum activity against DNA viruses, including human papilloma virus (HPV). However, data on the efficacy of cidofovir in an immunosuppressive setting remain contradictory. We report for the first time on the promotion of the healing of recalcitrant warts in a patient with myelodysplastic syndrome with intravenous cidofovir treatment.     

Premenstrual symptoms in black and white community samples

Premenstrual syndrome specialty clinics are reported to be almost exclusively attended by white women. This racial discrepancy has raised the question of whether there is a lower prevalence or severity of symptoms during the premenstruum among black women. The authors evaluated selected premenstrual symptoms in a representative community-based sample and found no difference in the prevalence or severity of premenstrual symptoms reported by black and white women, except for a higher prevalence of food cravings among blacks. Exploration of broader sociocultural factors may explain the observed racial difference in seeking help for premenstrual complaints.     

129A Summary of Scientific Studies and Clinical Results with a Glycerine Based Dressing

The importance of controlling the bioburden in wounds can not be over emphasized. Glycerine based gel sheets have been used extensively to show their bacteriostatic/fungistatic properties. Hoekstra studied animal wounds and compared glycerine dressings with water based dressings and the glycerine showed superior bioburden reduction. Vandeputte showed similar results when comparing hydrogel and hydrocolloid dressings and looked at the histology of the wounds to find differences in the quantities of the types of cells present. The reduced scar formation of wounds are thought to be attributed to the influence of the glycerine on the healing process. Hoestra has reported the dramatic reduction in the inflammation reaction soon after application of the glycerine gel dressing. Studies by Oliveria‐Gandia, Davis, and Mertz showed the glycerine dressings to be more effective than hydrogel or hydrocolloid dressings in reducing bioburden in animal wounds that were inoculated with microbes and also reducing biocounts in appropriate growth medium. Vandeputte conducted a diabetic study(no exclusions) that compared the glycerine dressing (n = 15) with standard protocol(n = 14) for diabetic foot wounds, that showed the test dressing to be far superior. He along with thousands of other nurses around the world have reported the use of glycerine dressings on superficial burns to reduce pain, reduce the chance for infection, reduce scar formation, and to protect the wound from friction and pressure. J. Baksa extensively used the glycerine gel sheets in his burn unit not only for the superficial wounds but also for 3^rd and 4^th degree burns on children as well as after surgical removal of hypertrophic and keloid scars to prevent reoccurrence. T.M. Baum and M.J. Busuito also reported the use of the glycerine dressing for scar prevention and treatment. The glycerine dressing has been used extensively for te treatment and prevention of pressure ulcers in hospitals, nursing homes, athletic fields, as well as, under casts, splints and braces. R. Horchner reported a >95% reduction in pressure ulcers in a direct comparison to the control and to hydrocolloids.     

Digital radiography of subtle pulmonary abnormalities: an ROC study of the effect of pixel size on observer performance

Forty conventional radiographs with examples of mild interstitial infiltrates and subtle pneumothoraces and 40 normal studies of the chest were selected and digitized, with pixel sizes of 1.0, 0.5, 0.2, and 0.1 mm. Observer performance tests were carried out using receiver operating characteristic analysis. Conventional radiographs and digitized images were compared. The results indicate that, in such cases, diagnostic accuracy increases significantly as the pixel size is reduced, at least to the 0.1-mm level. We conclude that, for digital systems using screen-film or similar image receptors, use of a pixel size substantially larger than 0.1 mm may result in some loss of diagnostic accuracy.     

Visual function in Huntington's disease patients and presymptomatic gene carriers.

Disturbances of visual cognition, visuomotor performance, and visual memory have been described frequently in Huntington's disease (HD). Early stage visual abnormalities could contribute to these deficits. We evaluated visual processing in 20 control subjects who were non-gene carriers at risk for HD, nine presymptomatic gene-positive subjects, and eight subjects with a recent diagnosis of Huntington's disease. Visual perceptual tests of contrast sensitivity and motion discrimination were used to probe early stage visual processing. Extraocular movements were evaluated in a neurologic examination, and the Digit Symbol test was used to test visual motor performance. Contrast sensitivity did not differ among the three groups. Motion discrimination was impaired in HD subjects but not in the presymptomatic gene carriers when compared to gene noncarriers. Among gene carriers, impaired motion discrimination performance was associated with poorer Digit Symbol performance and extraocular abnormalities. These findings suggest that the early stages of HD are associated with disturbances of motion perception as well as disruptions of visual motor and ocular motor performance.