Regulation of airway hyperresponsiveness by calcitonin gene-related peptide in allergen sensitized and challenged mice

Sensory neuropeptides are localized to airway nerves and endocrine cells in both human and animal species and may participate in the development of airway inflammation and hyperresponsiveness (AHR). We used a mouse model to identify the changes that occur in calcitonin gene-related peptide (CGRP) expression in the airways during development of allergic inflammation and to investigate the potential role of this neuropeptide in modulating AHR. In sensitized mice, allergen challenge induced eosinophilic airway inflammation and AHR and resulted in considerable depletion of CGRP in neuroepithelial bodies and submucosal nerve plexuses without altering the overall density of airway nerve fibers. This depletion was subsequent to the development of airway inflammation and was prevented by anti-very late antigen-4 and anti-interleukin-5 treatments, which blocked airway eosinophilia and abolished AHR. Administration of CGRP to sensitized and challenged mice resulted in the normalization of airway responsiveness to inhaled methacholine, an effect that was neutralized by the receptor antagonist CGRP(8-37). These data demonstrate that replacement of CGRP following its depletion in allergic mice can reverse the changes in airway responsiveness and suggest that CGRP may have potential for the treatment of allergic AHR.     

Study Protocol: A randomized controlled trial of patient navigation-activation to reduce cancer health disparities

Background  

Cancer health disparities affecting low-income and minority patients are well documented. Root-causes are multifactorial, including diagnostic and treatment delays, social and financial barriers, and poor communication. Patient navigation and communication coaching (activation) are potential interventions to address disparities in cancer treatment. The purpose of this clinical trial is to test the effectiveness of an intervention combining patient navigation and activation to improve cancer treatment.     

Interaction in families with obese children

In a controlled study using recently developed and validated methods for eliciting and describing family interactions, a characteristic dysfunctional pattern of interaction was found in families with an obese child. The pattern differed from patterns predicted by previous workers on the basis of indirect evidence or non-systematic study. The pattern was present in all the families studied, but was more marked in the sub-group recruited from a local school, than from subgroups recruited through medical sources. This sub-group had a more positive attitude to obesity and a slightly lower degree of obesity. No common or characteristic interactional pattern was found in the controls. The results were not explainable in terms of demographic criteria, family structure or composition variables, or family emotional health. The findings are discussed in relation to a model of obesity as a family syndrome and a manifestation of psychosocial identity.