全文获取类型
收费全文 | 1117篇 |
免费 | 111篇 |
国内免费 | 22篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 58篇 |
妇产科学 | 10篇 |
基础医学 | 215篇 |
口腔科学 | 52篇 |
临床医学 | 124篇 |
内科学 | 176篇 |
皮肤病学 | 32篇 |
神经病学 | 88篇 |
特种医学 | 219篇 |
外科学 | 47篇 |
综合类 | 38篇 |
预防医学 | 77篇 |
眼科学 | 4篇 |
药学 | 42篇 |
中国医学 | 1篇 |
肿瘤学 | 64篇 |
出版年
2022年 | 5篇 |
2020年 | 4篇 |
2019年 | 4篇 |
2018年 | 11篇 |
2017年 | 9篇 |
2016年 | 21篇 |
2015年 | 16篇 |
2014年 | 18篇 |
2013年 | 24篇 |
2012年 | 33篇 |
2011年 | 25篇 |
2010年 | 29篇 |
2009年 | 28篇 |
2008年 | 59篇 |
2007年 | 44篇 |
2006年 | 41篇 |
2005年 | 25篇 |
2004年 | 39篇 |
2003年 | 21篇 |
2002年 | 23篇 |
2001年 | 24篇 |
2000年 | 24篇 |
1999年 | 17篇 |
1998年 | 46篇 |
1997年 | 51篇 |
1996年 | 44篇 |
1995年 | 41篇 |
1994年 | 28篇 |
1993年 | 40篇 |
1992年 | 28篇 |
1991年 | 25篇 |
1990年 | 21篇 |
1989年 | 27篇 |
1988年 | 34篇 |
1987年 | 47篇 |
1986年 | 37篇 |
1985年 | 25篇 |
1984年 | 11篇 |
1983年 | 15篇 |
1982年 | 16篇 |
1981年 | 22篇 |
1980年 | 24篇 |
1979年 | 10篇 |
1978年 | 7篇 |
1977年 | 10篇 |
1976年 | 24篇 |
1975年 | 12篇 |
1934年 | 4篇 |
1927年 | 4篇 |
1926年 | 4篇 |
排序方式: 共有1250条查询结果,搜索用时 671 毫秒
1.
2.
Different mechanisms by which anti-DNA MoAbs bind to human endothelial cells and glomerular mesangial cells. 下载免费PDF全文
T M Chan G Frampton N A Staines P Hobby G J Perry J S Cameron 《Clinical and experimental immunology》1992,88(1):68-74
The mechanisms by which anti-DNA MoAbs derived from MRL-lpr/lpr mice, bind to human umbilical vein endothelial cells (HUVEC) and glomerular mesangial cells were studied using a cellular ELISA. DNAse-treatment of either the MoAb or HUVEC followed by reconstitution with DNA and/or histones was performed to determine whether DNA and histones mediated such binding. It was found that MoAb410 bound to HUVEC and mesangial cells in the form of preformed DNA/anti-DNA immune complex, and such binding was facilitated by histones. In contrast, MoAb 152 bound directly to cell membrane-associated DNA, and adding DNA to MoAb 152 reduced its cellular binding. DNA binds endothelial cell surface and histones enhance the binding of both MoAb 410 and MoAb 152 to HUVEC by increasing cell membrane-associated DNA. Finally, the degree of MoAb binding to HUVEC is critically influenced by the relative concentrations of antibody, DNA, and histones. 相似文献
3.
4.
5.
Ralls PW; Johnson MB; Kanel G; Dobalian DM; Colletti PM; Boswell WD Jr; Radin DR; Halls JM 《Radiology》1986,161(2):451-454
FM sonography - a signal-processing technique that uses frequency and phase information as well as amplitude data - shows promise in evaluation of patients with diffuse liver disease. In a prospective blinded review of 37 patients with biopsy-proved liver disease and 42 healthy volunteers, FM sonography was clearly superior to traditional amplitude-based (AM) sonography in distinguishing healthy from diseased subjects. Statistically significant differences were seen in accuracy (FM, 98.7%; AM, 84.8%), sensitivity (FM, 97.3%; AM, 70.3%), and negative predictive value (FM, 97.7%; AM, 78.8%). Our data also suggest that current FM sonographic techniques cannot differentiate among histologic findings associated with different hepatic parenchymal abnormalities. It is unclear, therefore, whether FM imaging can reduce the numbers of patients who require biopsy for diagnosis or the frequency of biopsy procedures in patients with known disease. 相似文献
6.
7.
8.
Yoshimitsu Kuroyanagi DR. ENG DR. SCI DR. MED ; Akihiko Shiraishi MD ; Yoshiteru Shirasaki MD ; Nobuaki Nakakita MD ; Yoshiaki Yasutomi MD ; Yasuo Takano MD ; Nobuyuki Shioya MD FACS 《Wound repair and regeneration》1994,2(2):122-129
A bilaminar wound dressing composed of an outer membrane and an inner three-dimensional matrix of a fabric or a sponge may be considered to constitute an ideal structure that promotes wound healing: the outer membrane prevents body fluid loss, controls water evaporation, and protects the wound surface from bacterial invasion, and the inner matrix encourages adherence by tissue growth into the matrix. Using this concept, we developed a biosynthetic wound dressing with a drug delivery capability. This medicated wound dressing is composed of a spongy sheet of a chitosane derivative and collagen mixture that is laminated to an antimicrobial-impregnated polyurethane membrane. In this study, a gentamycin sulfate-impregnated wound dressing was prepared and evaluated. The antimicrobial efficacy of this wound dressing was examined on an agar plate seeded with Pseudomonas aeruginosa. Also, the cytotoxicity of an antimicrobial released from this wound dressing was examined in an in vitro system with cultured skin substitutes. Both in vitro tests have shown that this wound dressing is capable of suppressing bacterial growth and minimizing cellular damage. In addition, in the treatment of wounds inflicted on rats and rabbits, this wound dressing was shown to be efficacious in covering full-thickness and split-thickness skin defects. Finally, the efficacy of this wound dressing was evaluated in a nonrandomized open-label study of 31 clinical cases. In 31 cases treated with this wound dressing, good or excellent wound healing was achieved. 相似文献
9.
DR Foster 《Journal of Medical Imaging and Radiation Oncology》1995,39(4):399-400
The use of self-expanding prostheses in the management of malignant oesophageal strictures has become well established. The majority of benign peptic oesophageal strictures can be successfully managed using endoscopic or fluoroscopically guided balloon oesophageal dilatation combined with long-term drug therapy, particularly using proton pumper inhibitors. Although endoscopic oesophageal dilatation can be performed on an outpatient basis, it requires repeated hospital visits. There is a small risk of oesophageal perforation whilst cardio-respiratory complications may be encountered during the use of intravenous sedation in an elderly population. The use of a self-expanding Strecker stent in a 98 year old woman with a benign oesophageal stricture is described. 相似文献
10.
Incidence of childhood diabetes mellitus in Yorkshire, northern England, is associated with nitrate in drinking water: an ecological analysis 总被引:7,自引:1,他引:6
R. C. Parslow P. A. McKinney G. R. Law A. Staines R. Williams H. J. Bodansky 《Diabetologia》1997,40(5):550-556
Summary The relationship between the incidence of childhood-onset insulin-dependent diabetes mellitus and levels of nitrate in drinking
water in the former Yorkshire Regional Health Authority was investigated by means of an ecological analysis. A population-based
register contributed 1797 0–16-year-olds diagnosed with diabetes between 1978 and 1994. Nitrate data were based on 9330 samples
of drinking water tested between 1990 and 1995 in 148 water supply zones, for which 1991 census small area statistics were
taken on population density, ethnicity and socio-economic status. Diabetes incidence was positively associated with raised
mean nitrate levels with a standardised incidence ratio of 115 in zones with greater than 14.85 mg · l–1 (χ2 = 26.81, 1 df, p < 0.001). Significant negative trends were found between standardised incidence ratios and proportion of non-whites in the
population (χ2 = 33.57, 1 df, p < 0.001), childhood population density (χ2 = 30.81, 1 df, p < 0.001) and the Townsend deprivation score (χ2 = 33.89, 1 df, p < 0.001). Poisson regression modelling, adjusting for the other factors, showed a significant increase in relative incidence
rate ratio from a baseline of 1 at nitrate levels below 3.22 mg · l–1 to 1.27 (95 % confidence interval 1.09,1.48) for mean nitrate levels above 14.85 mg · l–1. An association between higher nitrate levels in domestic drinking water and incidence of childhood diabetes has been demonstrated.
This was not explained by the ethnic composition of the population, population density or socioeconomic status. Nitrate in
drinking water may be a precursor of chemicals which are toxic to the pancreas. [Diabetologia (1997) 40: 550–556]
Received: 24 October 1996 and in revised form: 20 December 1996 相似文献