Secretion,blood levels and cutaneous expression of TL1A in psoriasis patients

TL1A is a TNF‐like cytokine which has been shown to co‐stimulate TH1 and TH17 responses during chronic inflammation. The expression of this novel cytokine has been investigated in inflammatory disorders like rheumatoid arthritis and inflammatory bowel disease, but little is known about expression and induction in psoriasis. Indeed, the pathogenesis in psoriasis is still not fully understood and it is speculated that cytokines other than TNF‐α are important in subsets of patients. Also, for patients with severe disease that are treated with systemic anti‐TNF‐α blockade, novel candidates to be used as disease and response biomarkers are of high interest. Here, we demonstrate TL1A expression in biopsies from psoriatic lesions. Also, we investigated spontaneous and induced TL1A secretion from PBMCs and blood levels from a cohort of psoriasis patients. Here, increased spontaneous secretion from PBMCs was observed as compared to healthy controls and a small subset of patients had highly elevated TL1A in the blood. Interestingly, activation of PBMCs with various cytokines showed a decreased sensitivity for TL1A activation in psoriasis patients compared to healthy controls.TL1A levels in blood and biopsies could not be correlated with disease activity with this patient cohort. Thus, additional large‐scale studies are warranted to investigate TL1A as a biomarker.     

Tumoren des oberen Gastrointestinaltrakts: Beispiele und Ergebnisse der Interdisziplinarität

Der überwiegende Anteil an Tumoren im oberen Gastrointestinaltrakt wird erst im fortgeschrittenen Stadium entdeckt. Daher bleibt die operative Resektion als Standardtherapie für die meisten Patienten palliativ.An 3 Fallbeispielen soll aufgezeigt werden,welche M?glichkeiten durch interdisziplin?re Therapie bestehen, um die l?ngerfristige Prognose der Patienten zu verbessern. PD Dr.M. Stahl Innere Klinik IV, Internistische Onkologie und H?matologie,Kliniken Essen-Mitte, Essen, E-Mail: m.stahl@kliniken-essen-mitte.de