全文获取类型
收费全文 | 774篇 |
免费 | 56篇 |
国内免费 | 34篇 |
专业分类
儿科学 | 41篇 |
妇产科学 | 6篇 |
基础医学 | 103篇 |
口腔科学 | 24篇 |
临床医学 | 112篇 |
内科学 | 152篇 |
皮肤病学 | 15篇 |
神经病学 | 30篇 |
特种医学 | 127篇 |
外科学 | 90篇 |
综合类 | 15篇 |
预防医学 | 29篇 |
眼科学 | 4篇 |
药学 | 95篇 |
肿瘤学 | 21篇 |
出版年
2021年 | 5篇 |
2020年 | 4篇 |
2019年 | 4篇 |
2018年 | 11篇 |
2017年 | 5篇 |
2016年 | 10篇 |
2015年 | 12篇 |
2014年 | 25篇 |
2013年 | 34篇 |
2012年 | 18篇 |
2011年 | 19篇 |
2010年 | 27篇 |
2009年 | 47篇 |
2008年 | 16篇 |
2007年 | 36篇 |
2006年 | 24篇 |
2005年 | 24篇 |
2004年 | 15篇 |
2003年 | 16篇 |
2002年 | 21篇 |
2001年 | 11篇 |
2000年 | 17篇 |
1999年 | 24篇 |
1998年 | 44篇 |
1997年 | 34篇 |
1996年 | 37篇 |
1995年 | 25篇 |
1994年 | 34篇 |
1993年 | 21篇 |
1992年 | 14篇 |
1991年 | 7篇 |
1990年 | 9篇 |
1989年 | 25篇 |
1988年 | 25篇 |
1987年 | 12篇 |
1986年 | 20篇 |
1985年 | 15篇 |
1984年 | 15篇 |
1983年 | 13篇 |
1982年 | 12篇 |
1981年 | 14篇 |
1980年 | 12篇 |
1979年 | 3篇 |
1978年 | 5篇 |
1976年 | 11篇 |
1975年 | 11篇 |
1973年 | 3篇 |
1971年 | 3篇 |
1970年 | 4篇 |
1969年 | 4篇 |
排序方式: 共有864条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
Biodistribution and pharmacokinetics of the alphavbeta3-selective tracer 18F-galacto-RGD in cancer patients. 总被引:5,自引:0,他引:5
Ambros J Beer Roland Haubner Michael Goebel Stephan Luderschmidt Mary E Spilker Hans-Jürgen Wester Wolfgang A Weber Markus Schwaiger 《Journal of nuclear medicine》2005,46(8):1333-1341
(18)F-Galacto-RGD has been developed for PET of alpha(v)beta(3) integrin expression, a receptor involved in, for example, angiogenesis and metastasis. Our aim was to study the kinetics and biodistribution of (18)F-Galacto-RGD in cancer patients. METHODS: Nineteen patients with metastases of malignant melanoma (n = 7), sarcomas (n = 10), or osseous metastases (n = 2) were examined. After injection of 133-200 MBq (18)F-Galacto-RGD, 3 consecutive emission scans from the pelvis to the thorax or dynamic emission scans of the tumor over 60 min, followed by 1 static emission scan of the body, were acquired. Time-activity curves and standardized uptake values (SUVs) were derived by image region-of-interest analysis with image-based arterial input functions. Compartmental modeling was used to derive the distribution volume for muscle tissue and tumors. RESULTS: (18)F-Galacto-RGD showed rapid blood clearance and primarily renal excretion. SUVs in tumors ranged from 1.2 to 9.0. Tumor-to-blood and tumor-to-muscle ratios increased over time, with peak ratios of 3.1 +/- 2.0 and 7.7 +/- 4.3, respectively, at 72 min. The tumor kinetics were consistent with a 2-tissue compartment model with reversible specific binding. Distribution volume values were, on average, 4 times higher for tumor tissue (1.5 +/- 0.8) than those for muscle tissue (0.4 +/- 0.1). The data suggest that there was only minimal free and bound (specific or nonspecific) tracer in muscle tissue. CONCLUSION: (18)F-Galacto-RGD demonstrates a highly favorable biodistribution in humans with specific receptor binding. Most important, this study shows that (18)F-Galacto-RGD allows visualization of alpha(v)beta(3) expression in tumors with high contrast. Consequently, this tracer offers a new strategy for noninvasive monitoring of molecular processes and may supply helpful information for planning and controlling of therapeutic approaches targeting the alpha(v)beta(3) integrin. 相似文献
5.
We used arthrotomography to study the glenoid labrum in 114 patients. Sixty-nine of the patients had anatomic instability of the shoulder (including recurrent dislocation and subluxation of the shoulder), and 45 patients had functional instability of the shoulder (denoted by chronic pain, clicking of the joint, and the sensation that an unstable condition exists without the objective signs of it). Labral tears were revealed arthrotomographically in 86% of the patients with anatomic instability, while only 40% of the patients with functional instability had labral abnormalities, and these were primarily of minor severity. Fifty-six patients (44 of whom had anatomic instability; 12, functional instability) required surgery. The surgical findings were correlated with the arthrotomographic findings, and no false-positive results were revealed. However, arthrotomography demonstrated only part of the pathologic condition of two patients. These results confirm that there is a strong correlation between labral pathologic conditions and anatomic instability of the shoulder. Arthrotomographic studies have a great impact on the selection of therapy in cases of both anatomic and functional instability of the shoulder. 相似文献
6.
Hausegger KA; Cragg AH; Lammer J; Lafer M; Fluckiger F; Klein GE; Sternthal MH; Pilger E 《Radiology》1994,190(1):199
7.
Rosenberg ZS; Jahss MH; Noto AM; Shereff MJ; Cheung Y; Frey CC; Norman A 《Radiology》1988,167(2):489-493
Computed tomography (CT) was performed in 42 patients with 49 clinically suspected tears of the posterior tibial tendon. Twenty-eight of the 49 suspected tears were subsequently surgically explored and repaired. Three patterns of tendon abnormalities were recognized on CT scans: type I-intact, hypertrophied, heterogeneous tendon; type II-attenuated tendon; and type III-absence of a portion of a tendon. Types I and II correlated with partial rupture seen during surgery, and type III correlated with complete rupture of the tendon. CT findings were accurate in 96% of the patients who underwent surgery. In four cases (14%), tendon rupture was seen on CT scans, but the extent of the injury was underestimated and the rupture was misclassified. Reactive periostitis of the distal tibia was seen in 71% of diseased tendons and may represent an important factor in the diagnosis of tendon rupture. 相似文献
8.
9.
Ultra-early evaluation of intracerebral hemorrhage 总被引:48,自引:0,他引:48
The authors evaluate eight patients with intracerebral hemorrhage (ICH) who underwent computerized tomography (CT) within 2 1/2 hours after symptom onset and then again several hours later. The second CT scan was performed within 12 hours after onset for seven of the patients and 100 hours after onset for the eighth patient. In four patients, the second CT scan was obtained prospectively. The mean percentage of increase in the volume of hemorrhage between the first and second CT scans was 107% (range 1% to 338%). In each of the six patients with a greater than 40% increase in hemorrhage volume, neurological deterioration occurred soon after the first CT. A systolic blood pressure of 195 mm Hg or greater was recorded during the first 6 hours in five of the same six patients. The data from this study indicate that, in ICH, bleeding may continue after the 1st hour post-hemorrhage, particularly in patients with early clinical deterioration. 相似文献
10.
Peroneus quartus muscle: MR imaging features 总被引:2,自引:0,他引:2