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Nidaa Mikail Khadija Benali Besma Mahida Jonathan Vigne Fabien Hyafil François Rouzet Dominique Le Guludec 《Current cardiology reports》2018,20(3):14
Purpose of review
This review analyzes recent studies evaluating the diagnostic value of 18F-FDG-PET/CT for the detection of peripheral emboli and secondary infectious foci in patients with infective endocarditis and cardiac device infections.Recent findings
Detection of extracardiac septic localizations in patients with infective endocarditis and cardiac device infections is crucial, as it may impact the diagnosis, prognosis, and therapeutic management. Recent literature substantiated the clinical usefulness of 18F-FDG-PET/CT in this setting.Summary
18F-FDG-PET/CT has proven its high diagnostic value for the detection of peripheral emboli in patients with infective endocarditis and cardiac device infections, substantially affecting patients’ outcome and treatment. A multimodal approach, combining the high sensitivity of 18F-FDG-PET/CT with morphological imaging seems promising.8.
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Plantamura Julie Bousquet Aurore Otto Marie-Pierre Bigaillon Christine Legland Anne-Margaux Delacour Hervé Vest Philippe Astier Hélène Valero Elodie Bylicki Olivier Renard Christophe Martin Solenne Verret Catherine Garnotel Eric Foissaud Vincent Mérens Audrey Janvier Frédéric 《European journal of clinical microbiology & infectious diseases》2021,40(10):2191-2198
European Journal of Clinical Microbiology & Infectious Diseases - Molecular diagnosis on nasopharyngeal swabs (NPS) is the current standard for COVID-19 diagnosis, but saliva may be an... 相似文献
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Conditional ablation of NKp46+ cells using a novel Ncr1greenCre mouse strain: NK cells are essential for protection against pulmonary B16 metastases
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Leila Ben Merzoug Solenne Marie Naoko Satoh‐Takayama Sarah Lesjean Marcello Albanesi Hervé Luche Hans Jörg Fehling James P. Di Santo Christian A. J. Vosshenrich 《European journal of immunology》2014,44(11):3380-3391
To study gene functions specifically in NKp46+ cells we developed novel Cre mice allowing for conditional gene targeting in cells expressing Ncr1 (encoding NKp46). We generated transgenic Ncr1greenCre mice carrying an EGFPcre fusion under the control of a proximal Ncr1 promoter that faithfully directed EGFPcre expression to NKp46+ cells from lymphoid and nonlymphoid tissues. This approach allowed for direct detection of Cre‐expressing NKp46+ cells via their GFP signature by flow cytometry and histology. Cre was functional as evidenced by the NKp46+ cell‐specific expression of RFP in Ncr1greenCreRosa‐dtRFP reporter mice. We generated Ncr1greenCreIl2rgfl/fl mice that lack NKp46+ cells in an otherwise intact hematopoietic environment. Il2rg encodes the common gamma chain (γc), which is an essential receptor subunit for cytokines (IL‐2, ‐4, ‐7, ‐9, ‐15, and ‐21) that stimulate lymphocyte development and function. In Ncr1greenCreIl2rgfl/fl mice, NK cells are severely reduced and the few remaining NKp46+ cells escaping γc deletion failed to express GFP. Using this new NK‐cell‐deficient model, we demonstrate that the homeostasis of NKp46+ cells from all tissues (including the recently described intraepithelial ILC1 subset) requires Il2rg. Finally, Ncr1greenCreIl2rgfl/fl mice are unable to reject B16 lung metastases demonstrating the essential role of NKp46+ cells in antimelanoma immune responses. 相似文献