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Alexander S. Graphodatsky Polina L. Perelman Natalya V. Sokolovskaya Violetta R. Beklemisheva Natalya A. Serdukova Gauthier Dobigny Stephen J. O’Brien Malcolm A. Ferguson-Smith Fengtang Yang 《Chromosome research》2008,16(1):129-143
Canid species (dogs and foxes) have highly rearranged karyotypes and thus represent a challenge for conventional comparative
cytogenetic studies. Among them, the domestic dog is one of the best-mapped species in mammals, constituting an ideal reference
genome for comparative genomic study. Here we report the results of genome-wide comparative mapping of dog chromosome-specific
probes onto chromosomes of the dhole, fennec fox, and gray fox, as well as the mapping of red fox chromosome-specific probes
onto chromosomes of the corsac fox. We also present an integrated comparative chromosome map between the species studied here
and all canids studied previously. The integrated map demonstrates an extensive conservation of whole chromosome arms across
different canid species. In addition, we have generated a comprehensive genome phylogeny for the Canidae on the basis of the
chromosome rearrangements revealed by comparative painting. This genome phylogeny has provided new insights into the karyotypic
relationships among the canids. Our results, together with published data, allow the formulation of a likely Canidae ancestral
karyotype (CAK, 2n = 82), and reveal that at least 6–24 chromosomal fission/fusion events are needed to convert the CAK karyotype
to that of the modern canids.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
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E. P. Kasatkina D. E. Shilin A. L. Rosenbloom M. I. Pykov G. V. Ibragimova V. N. Sokolovskaya A. N. Matkovskaya T. N. Volkova E. A. Odoud M. I. Bronshtein A. M. Poverenny N. M. Mursankova 《European journal of pediatrics》1997,156(12):916-920
To determine the effects of low dose radiation from 131I and 137Cs resulting from the Chernobyl disaster on the expression of endemic goiter in children, we studied children in regions with
and without evidence of radiocontamination but comparable iodine insufficiency. We included 89 children in the study (radiocontaminated)
region (SR) and 116 in the control region (CR) because they were either fetuses, infants, or pre-adolescents at the time of
exposure. We evaluated thyroid dimensions by clinical examination and ultrasound; thyroid function by hormonal levels, and
thyroglobulin measurement; histology of the thyroid by fine needle aspiration; and thyroid autoimmunity. SR subjects had 5
times the frequency of thyroid enlargement as those from CR, greatest in the younger patients. There were no instances of
clinically apparent thyroid dysfunction. Antithyroid microsomal and antithyroglobulin antibodies were present in a markedly
greater percentage of SR subjects. Fine needle biopsy demonstrated greater cellular proliferation in samples from SR.
Conclusions We have demonstrated findings of autoimmune thyroid disease at markedly increased frequency in a population of children with
poor iodine nutriture who were exposed to low level radiation, compared to a more iodine deficient population not so exposed.
These results suggest that low level radiation may induce thyroid gland changes in children who have inadequate iodine intake
nutriture and reinforce the importance of adequate dietary iodine.
Received: 14 June 1996 / Accepted in revised form: 20 June 1997 相似文献
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S. A. Vasil'ev G. M. Golubushina V. I. Kabachnyi M. S. Luk'yanchikov G. I. Molchanov T. I. Sokolovskaya V. P. Khilya 《Pharmaceutical Chemistry Journal》1990,24(9):641-645
Translated from Khimiko-farmatsevticheskii Zhurnal, Vol. 24, No. 9, pp. 38–41, September, 1990. 相似文献
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Nikiforova N. V. Tananaeva I. K. Pozdnyakov A. L. Sokolovskaya I. V. 《Bulletin of experimental biology and medicine》1978,85(6):738-742
The character of the hyperlipidemia was studied in rats with chronic uremia caused by removal of five-sixths of the total weight of kidney tissue. The blood cholesterol and phospholipid concentrations were almost twice the normal level 13–30 days after subtotal nephrectomy in the rats with uremia. The hyperlipidemia was more marked when the blood nonprotein nitrogen level was high. The serum triglyceride concentration was not increased. The total concentration of serum -and pre--lipoproteins, determined nephelometrically, was significantly increased only if the nonprotein nitrogen exceeded 80 mg%. Disk electrophoresis of the serum lipoproteins of the rats with uremia revealed a definite increase in the -lipoprotein concentration and a very small increase in the -lipoprotein concentration. Postheparin plasma lipolytic activity in the rats with uremia was normal. Massive proteinuria was observed in the experimental rats, but the hypoproteinemia was not significant.Nephrology Problem Laboratory, I. M. Sechenov First Moscow Medical Institute. Pathomorphological Laboratory, Institute of Nutrition, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR E. M. Tareev.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 85, No. 6, pp. 676–679, June, 1978. 相似文献
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Makhaeva GF Malygin VV Strakhova NN Sigolaeva LV Sokolovskaya LG Eremenko AV Kurochkin IN Richardson RJ 《Human & experimental toxicology》2007,26(4):273-282
Organophosphates (OPs) that inhibit neuropathy target esterase (NTE) with subsequent ageing can produce OP-induced delayed neuropathy (OPIDN). NTE inhibition in lymphocytes can be used as a biomarker of exposure to neuropathic OPs. An electrochemical method was developed to assay NTE in whole blood. The high sensitivity of the tyrosinase carbon-paste biosensors for the phenol produced by hydrolysis of the substrate, phenyl valerate, allowed NTE activity to be measured in diluted samples of whole blood, which cannot be done using the standard colorimetric assay. The biosensor was used to establish correlations of NTE inhibitions in blood with that in lymphocytes and brain after dosing hens with a neuropathic OP. The results of further studies demonstrated that whole blood NTE is a reliable biomarker of neuropathic OPs for up to 96 hours after exposure. These validation results suggest that the biosensor NTE assay for whole blood could be developed to measure human exposure to neuropathic OPs as a predictor of OPIDN. The small blood volume required (100 microL), simplicity of sample preparation and rapid analysis times indicate that the biosensor should be useful in biomonitoring and epidemiological studies. The present paper is an overview of our previous and ongoing work in this area. 相似文献
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A healthy 70-year-old woman who took nimesulide for 5 days, presented 2 weeks later with jaundice for which no other cause was found. Laboratory evidence of coagulopathy, hypoalbuminaemia and hypoglycaemia were present on admission, and liver biopsy showed massive necrosis of hepatocytes and severe inflammatory infiltrate. Despite supportive and corticosteroid treatment, her jaundice deepened and progressive acute renal failure developed, characterized by a 'prerenal' profile changing into irreversible acute tubular necrosis pattern, coma, occult Gram-negative sepsis and death. Although rare, nimesulide-associated hepatotoxicity and nephrotoxicity may occur and should be recognized as early as possible, to ensure immediate drug withdrawal and treatment. 相似文献