全文获取类型
收费全文 | 10758篇 |
免费 | 732篇 |
国内免费 | 64篇 |
专业分类
耳鼻咽喉 | 62篇 |
儿科学 | 244篇 |
妇产科学 | 280篇 |
基础医学 | 1531篇 |
口腔科学 | 396篇 |
临床医学 | 997篇 |
内科学 | 2200篇 |
皮肤病学 | 191篇 |
神经病学 | 1328篇 |
特种医学 | 321篇 |
外科学 | 1252篇 |
综合类 | 24篇 |
现状与发展 | 1篇 |
一般理论 | 8篇 |
预防医学 | 978篇 |
眼科学 | 121篇 |
药学 | 688篇 |
中国医学 | 49篇 |
肿瘤学 | 883篇 |
出版年
2024年 | 17篇 |
2023年 | 121篇 |
2022年 | 247篇 |
2021年 | 422篇 |
2020年 | 256篇 |
2019年 | 393篇 |
2018年 | 428篇 |
2017年 | 340篇 |
2016年 | 393篇 |
2015年 | 366篇 |
2014年 | 461篇 |
2013年 | 603篇 |
2012年 | 868篇 |
2011年 | 846篇 |
2010年 | 453篇 |
2009年 | 425篇 |
2008年 | 671篇 |
2007年 | 639篇 |
2006年 | 627篇 |
2005年 | 569篇 |
2004年 | 533篇 |
2003年 | 471篇 |
2002年 | 384篇 |
2001年 | 115篇 |
2000年 | 83篇 |
1999年 | 109篇 |
1998年 | 58篇 |
1997年 | 69篇 |
1996年 | 39篇 |
1995年 | 34篇 |
1994年 | 31篇 |
1993年 | 24篇 |
1992年 | 51篇 |
1991年 | 64篇 |
1990年 | 33篇 |
1989年 | 40篇 |
1988年 | 32篇 |
1987年 | 33篇 |
1986年 | 27篇 |
1985年 | 25篇 |
1984年 | 25篇 |
1983年 | 8篇 |
1982年 | 15篇 |
1981年 | 9篇 |
1980年 | 8篇 |
1979年 | 11篇 |
1977年 | 11篇 |
1974年 | 12篇 |
1973年 | 8篇 |
1971年 | 8篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Cost‐Effectiveness and Cost‐Utility Analysis of Spinal Cord Stimulation in Patients With Failed Back Surgery Syndrome: Results From the PRECISE Study 下载免费PDF全文
Furio Zucco MD Roberta Ciampichini MSc Angelo Lavano MD Amedeo Costantini MD Marisa De Rose MD Paolo Poli MD Gianpaolo Fortini MD Laura Demartini MD Enrico De Simone MD Valentino Menardo MD Piero Cisotto MD Mario Meglio MD Luciana Scalone PhD Lorenzo G. Mantovani DSc 《Neuromodulation》2015,18(4):266-276
2.
3.
Distinct genetic alterations and luminal molecular subtype in nested variant of urothelial carcinoma
4.
5.
6.
7.
G. Famularo F. M. Corsi G. Minisola C. De Simone G. C. Nicotra 《European journal of neurology》2007,14(8):940-943
There is no report of patients in whom pathological laughter, a rare condition characterized by uncontrollable episodes of laughter usually triggered by unrelated stimuli, was ever closely associated with a loss of consciousness overtly linked with the onset of such uncontrollable laughter, also referred to as a gelastic syncope. A 53-year-old man presented with a 4-month history of syncope following intense and uncoordinated laughter. Physical and neurological examination was normal and the patient had no other typical cerebellar signs. We found a mass in the cerebellar vermis abutting the floor of the fourth ventricle, which upon histological examination after surgery proved to be an ependymoma. We emphasize that pathological laughter and gelastic syncope could represent unique and sole features of a cerebellar disorder. 相似文献
8.
9.
Giorgio Ciprandi Mara De Amici Simone Negrini Gianluigi Marseglia Maria Angela Tosca 《International immunopharmacology》2009,9(10):1247-1249
Two new T cell subsets may be involved in allergic rhinitis (AR) pathogenesis: Th17 and T regulatory cells, mainly producing IL-17 and TGF-β respectively. Successful Sublingual Immunotherapy (SLIT) induces relevant immunological changes, thus the aim of this study was to evaluate serum IL-17 and TGF-β levels in AR patients treated with SLIT for 2 years. Patients' blood samples were collected before initiating SLIT (baseline), three months after the end of the first pre-seasonal SLIT course, and at the end of the second pre-seasonal course. IL-17 was detectable only in the most severe allergic patients. SLIT significantly induced an increase in serum TGF-β levels. There was moreover a significant relationship between TGF-β and symptom severity and drug use at the end of the study. Therefore, this study provides clinically relevant evidence that two pre-seasonal SLIT courses may significantly affect serum TGF-β levels. 相似文献
10.
Nutritional-inflammation status and resistance to erythropoietin therapy in haemodialysis patients. 总被引:1,自引:0,他引:1
Francesco Locatelli Simeone Andrulli Bruno Memoli Camilla Maffei Lucia Del Vecchio Stefano Aterini Walter De Simone Antonella Mandalari Giuliano Brunori Marcello Amato Bruno Cianciaruso Carmine Zoccali 《Nephrology, dialysis, transplantation》2006,21(4):991-998
BACKGROUND: Chronic kidney disease patients who are resistant to erythropoietin (EPO) treatment may suffer from malnutrition and/or inflammation. METHODS: In a cross-sectional study of haemodialysis patients, we investigated the relationship between the natural logarithm of the weekly EPO dose normalized for post-dialysis body weight and outcome measures of nutrition and/or inflammation [BMI, albumin and C reactive protein (CRP)] by means of multiple linear regression analysis. On the basis of the decile distribution of weekly EPO doses, we also evaluated four groups of patients: untreated, hyper-responders, normo-responders and hypo-responders. RESULTS: Six hundred and seventy-seven adult haemodialysis patients were recruited from five Italian centres. BMI and albumin were lower in the hypo-responders than in the other groups (21.3+/-3.8 vs 24.4+/-4.7 kg/m(2), P<0.001; and 3.8+/-0.6 vs 4.1+/-0.4 g/dl, P<0.001), whereas the median CRP level was higher (1.9 vs 0.8 mg/dl, P = 0.004). The median weekly EPO dose ranged from 30 IU/kg/week in the hyper-responsive group to 263 IU/kg/week in the hypo-responsive group. Transferrin saturation linearly decreased from the hyper- to hypo-responsive group (37+/-15 to 25+/-10%, P = 0.003), without any differences in transferrin levels. Ferritin levels were lower in the hypo-responsive than in the other patients (median 318 vs 445 ng/ml, P = 0.01). At multiple linear regression analysis, haemoglobin, BMI, albumin, CRP and serum iron levels were independently associated with the natural logarithm of the weekly EPO dose (R(2) = 0.22). CONCLUSIONS: Our findings support a clear association between EPO responsiveness and nutritional and inflammation variables in haemodialysis patients; iron deficiency is still a major cause of hypo-responsiveness. 相似文献