全文获取类型
收费全文 | 1034篇 |
免费 | 139篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 47篇 |
妇产科学 | 63篇 |
基础医学 | 153篇 |
口腔科学 | 13篇 |
临床医学 | 137篇 |
内科学 | 215篇 |
皮肤病学 | 16篇 |
神经病学 | 69篇 |
特种医学 | 59篇 |
外科学 | 77篇 |
综合类 | 20篇 |
预防医学 | 188篇 |
眼科学 | 16篇 |
药学 | 62篇 |
肿瘤学 | 46篇 |
出版年
2022年 | 10篇 |
2021年 | 17篇 |
2020年 | 8篇 |
2019年 | 6篇 |
2018年 | 22篇 |
2017年 | 28篇 |
2016年 | 18篇 |
2015年 | 18篇 |
2014年 | 26篇 |
2013年 | 47篇 |
2012年 | 43篇 |
2011年 | 55篇 |
2010年 | 30篇 |
2009年 | 34篇 |
2008年 | 38篇 |
2007年 | 42篇 |
2006年 | 35篇 |
2005年 | 52篇 |
2004年 | 34篇 |
2003年 | 26篇 |
2002年 | 35篇 |
2001年 | 39篇 |
2000年 | 23篇 |
1999年 | 42篇 |
1998年 | 18篇 |
1997年 | 21篇 |
1996年 | 21篇 |
1995年 | 26篇 |
1994年 | 23篇 |
1993年 | 11篇 |
1992年 | 20篇 |
1991年 | 29篇 |
1990年 | 22篇 |
1989年 | 27篇 |
1988年 | 23篇 |
1987年 | 26篇 |
1986年 | 30篇 |
1985年 | 18篇 |
1984年 | 25篇 |
1983年 | 11篇 |
1982年 | 12篇 |
1981年 | 8篇 |
1980年 | 5篇 |
1979年 | 12篇 |
1978年 | 7篇 |
1977年 | 4篇 |
1975年 | 5篇 |
1974年 | 4篇 |
1943年 | 3篇 |
1932年 | 4篇 |
排序方式: 共有1185条查询结果,搜索用时 31 毫秒
1.
2.
3.
In a cohort of 919 patients with definite or classic rheumatoid arthritis followed prospectively since 1966, we identified 36 patients with Felty's syndrome (FS). Their clinical course was compared to that of 72 matched controls from the same cohort. Patients with FS had more extraarticular features and more infections than control patients. The presence of joint erosions, serial Lansbury indices, and death rates were similar in both groups. Cardiovascular disease was the commonest cause of death in both groups, accounting for 32% of all deaths. Sepsis accounted for 10% of deaths in the group with FS and 13% of deaths in the controls. 相似文献
4.
Two human parathyroid hormone-related protein (hPTHrP) fragments were tested for effects on maternofetal transfer of 45Ca and Mg across the in-situ perfused rat placenta at 21 days of gestation (term = 23 days). The fetal placental circulation was perfused with a Mg-free Krebs-Ringer solution and the unidirectional maternofetal clearance (Kmf) of 45Ca and Mg compared with that of 51Cr-EDTA, the latter being employed as a paracellular diffusional marker. Placental perfusion with hPTHrP(1-34) (100 ng/ml) or hPTHrP(75-86)amide (50 ng/ml) did not significantly alter the Kmf of 45Ca or that of Mg. In separate rats, however, hPTHrP(1-34) but not hPTHrP(75-86)amide stimulated marked placental cyclic AMP (cAMP) release, the peak response of 63 +/- 7 pmol/min occurring 10 min after the beginning of the peptide perfusion. A lower dose of hPTHrP(1-34) (4 ng/ml) produced a similar peak release of cAMP, as did [Nle8,21, Tyr34]-rPTH(1-34)amide (4 ng/ml) and the adenylate cyclase agonist forskolin (17 mumol/l). Forskolin also rapidly increased the Kmf of 45Ca but not that of Mg or 51Cr-EDTA. The present study indicates that hPTHrP does not acutely affect maternofetal transfer of Ca or Mg across the perfused rat placenta. The data also question the role played by cAMP in the stimulatory actions of forskolin on placental Ca transport. 相似文献
5.
6.
P S Almond K J Gillingham R Sibley A Moss M Melin J Leventhal C Manivel P Kyriakides W D Payne D L Dunn 《Transplantation》1992,53(2):316-323
Although the nephrotoxic side effects of cyclosporine are well known, the impact of long-term CsA on renal transplant function is uncertain. We studied 5-10-year renal function in 347 CsA-treated patients, and in 64 randomly selected non-CsA-treated patients who had a minimum of 55 months of graft function. Non-CsA patients had a lower creatinine (Cr) level at one year than CsA patients (P = .001), with no change in renal function over time (P = .6). In CsA-treated patients there was also no suggestion of progressive renal damage, as evidenced by no change in Cr or 1/Cr. Simple linear regression models of 1/Cr vs. time for the first 10 years posttransplant were fit to the data for each patient. Analysis of the Y-intercept estimates from these regressions showed that age (P = .001), sex (P = .001), cyclosporine toxicity (P = .024), and initial cyclosporine dosage (P = .016) significantly affected the one-year serum Cr. Variables not affecting one-year Cr included donor source, early rejection episodes, late rejection episodes, ATN, diabetes, transplant number, HLA ABDR mismatch (for cadaver transplants), maximum PRA, and PRA at transplant. Analysis of the slope estimates from the regressions revealed that only age (P = .001) and late rejection episodes (P = .001) significantly affected the rate of change in 1/Cr over time. We conclude that, in long-term renal transplant patients, there is no evidence of progressive deterioration in renal function due to CsA nephrotoxicity. 相似文献
7.
Embolisation of the internal iliac artery was preformed under local anaesthesia in eight patients with severe bladder haemorrhage and in two with severe bleeding from the prostatic bed after prostatectomy. Good and effective control of the bleeding was achieved in six of the patients with bladder haemorrhage, with a partial response in the other two. Both patients with post-prostatectomy bleeding responded well to embolisation, with prompt cessation of the bleeding. This technique is recommended for the control of severe bleeding from the bladder or prostate in the seriously ill patient. 相似文献
8.
9.
10.
Douglas W. Huestis Robert M. Rifkin Brian G. M. Durie William A. Sibley Mehraboon Irani 《Journal of clinical apheresis》1992,7(2):75-77
Extracorporeal immune adsorption with staphylococcal protein A (SPA) columns can remove immune complexes and immunoglobulins in the treatment of a variety of diseases. We present the case of an elderly man with neuropathy associated with monoclonal gammopathy, treated by 3 on-line SPA procedures. At the completion of these treatments his neuropathy relapsed, progressing to near-total paralysis. Return to a baseline clinical status required several months. The reason for this severe relapse is not clear. Possible explanations include SPA activation of T-lymphocytes, with release of gamma interferon and increased antigen recognition, or removal of an anti-idiotype control mechanism. We advise caution in the application of immunoadsorption to conditions in which it has not yet been evaluated. © 1992 Wiley-Liss, Inc. 相似文献