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1.
2.
Toru Yamaguchi Ippei Kanazawa Masahiro Yamamoto Soichi Kurioka Mika Yamauchi Shozo Yano Toshitsugu Sugimoto 《BONE》2009,44(2):174-179
The association of bone with the metabolic syndrome and its features, visceral fat accumulation or insulin resistance, remains unclear. We determined visceral and subcutaneous fat areas (V and S) by computed tomography on 187 men (28–83 years) and 125 postmenopausal women (46–82 years) with type 2 diabetes. Men whose V was 100 cm2 or more had significantly lower urinary N-terminal cross-linked telopeptide of type-I collagen (p = 0.005), higher femoral neck bone mineral density (FN-BMD) (p = 0.004), and lower prevalence of vertebral fractures (VFs) (p = 0.04) than controls. Fat mass, V, S, and lean body mass positively correlated with FN-BMD in men and with lumbar (L) and FN-BMD in women. When adjusted for weight, these correlations became negative. Urinary C-peptide positively correlated with FN-BMD in both genders. Multivariate logistic regression analysis adjusted for age, height, weight, L-BMD, duration of diabetes, and diabetes therapies identified V in men and urinary C-peptide in women as factors inversely associated with the presence of VFs [odds ratio (OR) = 0.61 per SD increase, p = 0.04, and OR = 0.32, p = 0.01, respectively]. These findings suggest that, of the components of the metabolic syndrome, body fat in gravity and hyperinsulinemia could increase FN-BMD in diabetic subjects. Visceral fat in men and hyperinsulinemia in women may protect against VFs independent of weight, L-BMD, diabetes duration, or therapies. 相似文献
3.
K Tanaka Y Miyake S Sasaki Y Ohya S Miyamoto I Matsunaga T Yoshida Y Hirota H Oda 《Magnesium research》2006,19(4):268-275
There have only been a few studies on the role of mineral intake in tooth loss. We investigated the association between mineral intake and the prevalence of tooth loss in Japan. We used the baseline data on 1002 pregnant women who were enrolled in the Osaka Maternal and Child Health Study between November 2001 and March 2003. Tooth loss was defined as the previous extraction of one or more teeth. Nutrient intake was assessed by a validated diet history questionnaire. Prevalence odds ratios and confidence intervals were estimated by applying a multiple logistic regression model. The adjusted odds ratio upon comparison of the highest quartile with the lowest quartile of magnesium intake was 0.64 (95% confidence interval, 0.42-0.99), showing a tendency for an inverse dose-response relationship (p for linear trend = 0.05). There were no associations between the level of consumption of calcium, phosphate, iron, zinc, or copper and tooth loss. The present findings suggest that intake of magnesium is related to reduced prevalence of tooth loss among young Japanese women. 相似文献
4.
5.
T Yamagami S Iida T Kato T Hirota T Nishimura 《Journal of Medical Imaging and Radiation Oncology》2006,50(1):75-78
We present a patient with gastric varices complicating portal hypertension caused by liver cirrhosis related to hepatitis C virus. The patient underwent balloon‐occluded retrograde transvenous obliteration. The gastric varices almost completely disappeared, without any sclerotic agent being used, after iatrogenic injury of the gastrorenal shunt at the time of the interventional procedure. 相似文献
6.
A new diterpene antitumor antibiotic, myrocin C, has been isolated from the culture filtrate of a soil fungus, Myrothecium verrucaria strain No. 55. The antibiotic was effective against Gram-positive bacteria, fungi and yeasts, and prolonged the life span of mice bearing Ehrlich ascites carcinoma. 相似文献
7.
Do local anaesthetics interact with dihydropyridine binding sites on neuronal L-type Ca2+ channels? 总被引:1,自引:0,他引:1
Hirota K.; Browne T.; Appadu B. L.; Lambert D. G. 《British journal of anaesthesia》1997,78(2):185-188
We have examined the interaction of procaine, prilocaine, lignocaine,
bupivacaine, amylocaine and R(+) and S(-) ropivacaine with L-type
voltage-sensitive Ca2+ channels in rat cerebrocortical membranes. Membranes
were prepared in Tris HCl 50 mmol litre-1, pH 7.4, by homogenization and
centrifugation. Binding assays were performed in 1- ml volumes of Tris HCl
50 mmol litre-1, pH 7.4, for 90 min at room temperature using approximately
200 micrograms of protein. Non-specific binding was defined in the presence
of nifedipine 10(-5) mol litre-1, and bound and free radioactivity were
separated by vacuum filtration. The effects of local anaesthetics were
determined by displacement of [3H]PN200-110 (approximately 0.2 nmol
litre-1), a radiolabelled 1,4- dihydropyridine (DHP) L-channel antagonist.
The concentration of displacer producing 50% displacement was corrected for
the competing mass of [3H]PN200-110 to yield the affinity constant, K50.
All local anaesthetics displaced [3H]PN200-110 in a dose-dependent manner
with a rank order potency of (K50, mmol litre-1) bupivacaine (0.48),
amylocaine (0.74), lignocaine (1.09), prilocaine (2.06) and procaine
(2.09). Ropivacaine enantiomers did not show stereo-selective displacement,
with K50 values of 0.99 and 0.92 mmol litre-1 for R(+) and S(-)
ropivacaine, respectively. There was a significant correlation between pK50
and p (octanol:buffer partition coefficient) (r2 = 0.872, P = 0.020), pK50
and p (local anaesthetic potency) (r2 = 0.816, P = 0.036), pK50 and p
(relative conduction blocking potency) (r2 = 0.843, P = 0.028) and between
pK50 and p (IC50 for inhibition of cardiac output) (r2 = 0.897, P = 0.015).
These data suggest that DHP binding sites may be involved in both the
mechanism of local anaesthesia and the cardiotoxicity of these agents.
相似文献
8.
Shozo Baba 《World journal of surgery》1997,21(7):678-687
APC
gene and mismatch
repair genes. The role of these genes in colorectal carcinogenesis has
been studied intensively. The adenoma–carcinoma sequence was initially
proposed by Vogelstein, and the multistep carcinogenesis theory is now
well accepted. The various functions of the
APC
gene have
been elucidated.
APC
genes are considered to play a role in
shedding of the epithelial cells into the lumen. The mechanism behind
formation of a unicryptal adenoma is now better understood. Adenoma
formation is a monoclonal event with two hits of the
APC
gene. There is no zonal extension of the proliferative zone in the
background colonic mucosa of FAP patients. In addition to the
adenoma–carcinoma sequence, there seem to be various carcinogenetic
pathways in the development of colorectal cancer. A depressed type of
early cancer was recently found by the use of magnifying endoscopy. The
incidence of K-
ras
mutation was extremely low in this group
of early cancers. Some of the minute cancers show the
p53
mutation before the occurrence of
APC
mutation. Cancers of
microsatellite mutator phenotype show exaggerated genomic instability
at simple repeat sequences, such as TGFβRII. These genes may play a
suppressor role in a
p53
independent pathway of colorectal
carcinogenesis. We are now in an exciting era of this progressing field
of science. This genetic information may be more widely applicable
clinically in the near future (e.g., for presymptomatic diagnosis,
selection of patients for the most appropriate treatments, and
assessment of malignant potential). 相似文献
9.
Tohru SONODA Shozo OHDO Ken-ichi OHBA Takahiro OKISHIMA Kunio HAYAKAWA 《Congenital anomalies》1991,31(2):89-94
Sodium valproate was administered to Jcl:ICR mice in order to evaluate teratogenicity in the cardiovascular system. A single dose of 600mg/kg of sodium valproate was injected intraperitoneally on gestational day 6, 7, 8 or 9. On day 18 of gestation, dams were laparotomized to observe incidence and type of cardiovascular abnormality in live fetuses. Cardiovascular abnormalities were found most frequently in the group treated on day 7, being recognized in 86% of litters (19/22) and in 29% of live fetuses (70/238). Among these, there were 28 cases of transposition of the great arteries, 13 of double outlet right ventricle, 11 of endocardial cushion defect, 9 of ventricular septal defect, 5 of tricuspid atresia, and 4 of hypoplastic left heart syndrome. 相似文献
10.
Pharmacokinetic analysis of antibody localization in human colon cancer: Comparison with immunoscintigraphy 总被引:2,自引:0,他引:2
Atsushi Kubo Kayoko Nakamura Michiaki Katayama Shozo Hashimoto Tatsuo Teramoto Susumu Kodaira 《Annals of nuclear medicine》1992,6(1):21-27
The biodistribution and imaging characteristics of the 111In-labeled anti CEA monoclonal antibody ZCE-025 were studied in five patients with suspicion of colorectal carcinoma. Evaluation included antibody pharmacokinetics and assessment of antibody distribution in surgical specimen, making a comparison with whole-body imaging with a gamma camera. ZCE-025 localization in tumors was demonstrated by gamma-camera imaging in 4 of the 5 patients, corresponding to surgical findings. Persistent accumulation of 111In in the lymph nodes was observed in one patient, whereas surgical exploration of these lymph nodes showed no gross or microscopic evidence of metastases of colon carcinoma. Analysis of individual plasma by size exclusion HPLC showed two radioactivity peaks, labeled antibody and free DTPA. No transchelation of 111In to circulating transferrin was observed. The blood clearance was fitted to a two-compartment equation and its half-lives were found to be 10.8 +/- 8.7 h and 69.5 +/- 21.8 h for t1/2 alpha and t1/2 beta, respectively. Total urinary excretion averaged 0.3% of the injected dose/h with a small patient to patient variation. At 24 hrs postadministration the predominant radiolabeled species in urine was free DTPA. Thereafter, radioactivity in urine was partly present as a low molecular weight catabolic product. No apparent correlation between CEA content and uptake of 111In-ZCE-025 in tumors resected by surgery could be found. How 111In-labeled antibody is accumulated into tumors as well as into some nontumor tissues needs further study. 相似文献