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排序方式: 共有422条查询结果,搜索用时 15 毫秒
1.
Turnquist HR Vargas SE Schenk EL McIlhaney MM Reber AJ Solheim JC 《Immunologic research》2002,25(3):261-269
Prior to the binding of antigenic peptide, a complex of chaperone proteins associates with the Major Histocompatibility Complex
(MHC) class I heavy chain/β2m heterodimer. Although each dornain of the MHC class I heavy chain contains amino acid resid uses that influence chaperone
binding, there are several pieces of evidence that point to an interaction between the MHC clas 1α2/α3 domains and tapasin.
In egard to the site on tapasin involved in the tapasin/MHC interface, we have found that a particular region of tapasin (containing
amino acid residues 334–342) is necessary for the binding of tapasin to the MHC class I heavy chain. Our results also indicate
that amino acids in this region of tapasin also affect the proportion of MHC class I open forms expressed at the cell surface
and MHC class I egress from the endoplasmic reticulurn. Based on these results and those obtained by other laboratories, a
model for MHC class I/tapasin interaction is proposed. 相似文献
2.
Nicolette W. de Jong Severina Terlouw Frank E. van Boven M.S. van Maaren Marco W.J. Schreurs Dianne B.P.M. van den Berg-Somhorst Diederik Esser Shanna Bastiaan-Net 《Nutrients》2021,13(4)
Approximately 70% of birch pollen allergic patients in Europe experience hypersensitivity reactions to Immunoglobulin E (IgE) cross-reactive food sources. This so-called pollen-food syndrome (PFS) is defined by allergic symptoms elicited promptly by the ingestion of fruits, nuts, or vegetables in these patients. So far, in the literature, less attention has been given to Bet v 1 cross-reactive symptoms caused by pear (Pyrus communis). In the Netherlands, pears are widely consumed. The primary objective of this study was to measure the type and severity of allergic symptoms during pear challenges in birch pollen allergic patients, with a positive history of pear allergy, using two different pear varieties. Fifteen patients were included, skin prick test (SPT), prick-to-prick test (PTP), specific Immunoglobulin E (sIgE), and single-blind oral challenges were performed with two pear (Pyrus communis) varieties: the ‘Cepuna’ (brand name Migo®) and the ‘Conference’ pears. All patients were sensitized to one or both pear varieties. A total of 12 out of 15 participants developed symptoms during the ‘Cepuna’ food challenge and 14/15 reacted during the ‘Conference’ challenge. Challenges with the ‘Cepuna’ pears resulted in less objective symptoms (n = 2) in comparison with challenges with ‘Conference’ pears (n = 7). Although we did not find significance between both varieties in our study, we found a high likelihood of fewer and less severe symptoms during the ‘Cepuna’ challenges. Consequently selected pear sensitized patients can try to consume small doses of the ‘Cepuna’ pear outside the birch pollen season. 相似文献
3.
Guz Samantha Hecht Hillary K. Kattari Shanna K. Gross E. B. Ross Emily 《Archives of sexual behavior》2022,51(4):2135-2145
Archives of Sexual Behavior - Research on asexuality as a part of the experience of human sexuality has increased over the last two decades. However, there has not yet been a systematic review of... 相似文献
4.
Charlotte V. Hobbs Jan Drobeniuc Theresa Kittle John Williams Paul Byers Panayampalli S. Satheshkumar Kengo Inagaki Meagan Stephenson Sara S. Kim Manish M. Patel Brendan Flannery CDC COVID- Response Team CDC COVID- Response Team Bailey Alston Shanna J. Bolcen Darbi Boulay Peter Browning Li Cronin Ebenezer David Tonya Hayden Han Li Travis Lim Panagiotis Maniatis Palak Patel Mathew Pauly Amanda Poe Lili Punkova Vera Semenova Evelene P. Steward-Clark Alexandra Tejada Briana Zellner 《MMWR. Morbidity and mortality weekly report》2021,70(9):312
5.
目的:建立一种快速、有效的血清铜蓝蛋白(CP)筛查方法。方法:醋酸纤维膜电泳分离血清CP,盐酸联苯胺显示法。结果:用此方法可明确检测出Wilson氏病患者血清中CP含量的变化。结论:醋酸纤维膜电泳检测血清CP是一种有效的血清CP筛查方法。 相似文献
6.
Report of the ASFA apheresis registry on muscle specific kinase antibody positive myasthenia gravis 下载免费PDF全文
Chisa Yamada Huy P. Pham Yanyun Wu Laura Cooling Haewon C. Kim Shanna Morgan Joseph Schwartz Jeffrey L. Winters Edward C.C. Wong 《Journal of clinical apheresis》2017,32(1):5-11
Background : Anti‐muscle specific kinase antibody positive (MuSK Ab) myasthenia gravis (MG) patients are known to have different clinical course compared to anti‐acetylcholine receptor Ab positive MG patients. Therapeutic plasma exchange (TPE) has been reported to be effective; however, little is known of the response and of TPE procedural information. An ASFA Apheresis Registry was developed to analyze those data. Methods : The study collected detailed de‐identified patient data, TPE procedures, and treatment outcome/complications. Collected data was described in aggregate. Results : A total of 15 MuSK Ab MG patients with exacerbation of MG symptoms, 13 females/2 males, median age 44, were investigated. Thirty TPE courses (median 5 procedures/course, total 145 procedures) were evaluated. All TPE procedures were performed with citrate anticoagulation, 1 − 1.25 plasma volume exchange in 100% fluid balance, and 90% of courses used only albumin as replacement. Calcium was added to albumin or given orally as needed. TPE was performed every other day in 55% of courses. Adverse events occurred in 3.4% of procedures. Ten patients (67%) experienced relapses within a median of 7 weeks. Objective symptoms were resolved in more than 75% of courses. Overall subjective improvement rates were 94.1%/93.3% after 3/4 TPE procedures, respectively. Thirty‐one percent of patients responded poorly with minimal recovery. Conclusion : Overall subjective improvement was seen up to 94% of patients after one course of TPE. Some patients were poor‐responders. Five TPE may be adequate for initial course with additional TPE as needed. Based upon this preliminary data, we will modify our future data collection. J. Clin. Apheresis 32:5–11, 2017. © 2016 Wiley Periodicals, Inc. 相似文献
7.
Shanna M. Morgan Nicole D. Zantek Adam F. Carpenter 《Journal of clinical apheresis》2014,29(3):171-177
Neuromyelitis optica (NMO) is a relapsing inflammatory disease of the central nervous system that predominantly affects the spinal cord and optic nerves. The clinical hallmark of the disease is a step‐wise deterioration of visual and spinal cord function. This study reviews patients with steroid resistant relapsing NMO presenting for therapeutic plasma exchange (TPE) at our institution from December 2005 to December 2012. A total of five patients were treated with single volume TPE. Both subjective and objective clinical response to TPE was estimated by three different sources (the patient, a Transfusion Medicine physician, and the treating Neurologist) with the patient and Transfusion Medicine physician's final assessment of response made at the time of the last TPE in the series and the treating neurologist's assessment of response made at the time of the next neurological exam after the last TPE. A total of 17 TPE series were performed with the average course of therapy being three series (ranged 1–5) with five TPE (ranged 3–7) per series. All patients demonstrated improvement with each series of TPE and all procedures were well tolerated with only transient and well‐described reactions all of which were successfully resolved with minor or no sequelae. J. Clin. Apheresis 29:171–177, 2014. © 2013 Wiley Periodicals, Inc. 相似文献
8.
Wilson's disease (WD) is an autosomal‐recessive disorder of impaired copper metabolism resulting in accumulation of copper primarily in the liver but ultimately in many organs and tissues. A small number of patients with WD initially present with fulminant hepatic failure (FHF), hypercupremia, and intravascular hemolysis. The therapeutic goals for these patients include quickly removing the copper and preparing the patient for liver transplantation. Here, we report on a 6‐year‐old male with WD in FHF with anemia, renal insufficiency, and coagulopathy. The patient received a series of therapeutic plasma exchanges (TPE) as adjunctive therapy to remove copper and stabilize his coagulopathy and anemia until a transplant was possible. A total of five single plasma volume (1500 mL) TPE were performed over the course of 11 days with plasma as the replacement fluid. Laboratory results demonstrated temporary improvement after each procedure. Liver transplantation was performed 12 days after beginning TPE and 35 days after admission to the hospital. TPE was a successful adjunctive therapy to bridge this patient with WD to transplantation. J. Clin. Apheresis 27:282–286, 2012. © 2012 Wiley Periodicals, Inc. 相似文献
9.
Margaret Wrensch Ph.D. Shanna Swan Ph.D. Peter J. Murphy Ph.D. Jane Lipscomb Ph.D. Kathleen Claxton M.A. David Epstein M.A. 《Archives of environmental & occupational health》2013,68(4):210-216
We recently concluded that exposure to solvent-contaminated drinking water was an unlikely explanation for observed excesses of adverse pregnancy outcomes during 1980–1981 in the Los Paseos neighborhood of Santa Clara County, California, because these excesses were not observed in an adjacent exposed area. The validity of this conclusion depends on the assumption that the two areas had comparable exposure. Using quantitative methods to model movement of the solvent leak plume and water flow within the distribution system, we estimated that women with adverse outcomes were no more likely to have received contaminated water than women with normal live births. These results strengthen the conclusion that exposures to water from the contaminated well were not responsible for the excess of adverse outcomes observed in the Los Paseos area. 相似文献
10.
Annette Estes Lonnie Zwaigenbaum Hongbin Gu Tanya St. John Sarah Paterson Jed T. Elison Heather Hazlett Kelly Botteron Stephen R. Dager Robert T. Schultz Penelope Kostopoulos Alan Evans Geraldine Dawson Jordana Eliason Shanna Alvarez Joseph Piven IBIS network 《Journal of Neurodevelopmental Disorders》2015,7(1)