全文获取类型
收费全文 | 708篇 |
免费 | 57篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 25篇 |
妇产科学 | 3篇 |
基础医学 | 104篇 |
口腔科学 | 30篇 |
临床医学 | 114篇 |
内科学 | 122篇 |
皮肤病学 | 8篇 |
神经病学 | 28篇 |
特种医学 | 105篇 |
外科学 | 109篇 |
综合类 | 14篇 |
预防医学 | 38篇 |
眼科学 | 6篇 |
药学 | 32篇 |
肿瘤学 | 37篇 |
出版年
2022年 | 6篇 |
2021年 | 10篇 |
2020年 | 6篇 |
2019年 | 14篇 |
2018年 | 15篇 |
2017年 | 10篇 |
2016年 | 7篇 |
2015年 | 11篇 |
2014年 | 17篇 |
2013年 | 18篇 |
2012年 | 40篇 |
2011年 | 28篇 |
2010年 | 16篇 |
2009年 | 28篇 |
2008年 | 36篇 |
2007年 | 23篇 |
2006年 | 21篇 |
2005年 | 16篇 |
2004年 | 25篇 |
2003年 | 17篇 |
2002年 | 19篇 |
2001年 | 13篇 |
2000年 | 16篇 |
1999年 | 12篇 |
1998年 | 16篇 |
1997年 | 21篇 |
1996年 | 18篇 |
1995年 | 12篇 |
1994年 | 19篇 |
1993年 | 17篇 |
1992年 | 19篇 |
1991年 | 22篇 |
1990年 | 20篇 |
1989年 | 17篇 |
1988年 | 19篇 |
1987年 | 20篇 |
1986年 | 24篇 |
1985年 | 13篇 |
1984年 | 7篇 |
1983年 | 8篇 |
1982年 | 6篇 |
1981年 | 7篇 |
1980年 | 9篇 |
1979年 | 8篇 |
1978年 | 8篇 |
1977年 | 12篇 |
1976年 | 4篇 |
1975年 | 3篇 |
1973年 | 3篇 |
1972年 | 5篇 |
排序方式: 共有777条查询结果,搜索用时 31 毫秒
1.
TP Amadeu† AB Seabra‡ MG de Oliveira‡ AMA Costa† 《Journal of the European Academy of Dermatology and Venereology》2007,21(5):629-637
BACKGROUND: Nitric oxide (NO) plays a key role in wound repair and S-nitrosothiols like S-nitrosoglutathione (GSNO) are well known NO donors. METHODS: Animals were separated in two groups and submitted to excisional wounds on the dorsal surface at the first day. GSNO (100 microm)-containing hydrogels were topically applied on the wound bed in the GSNO group, daily, during the first 4 days. Control group was topically treated with hydrogel without GSNO for the same period. Wound contraction and re-epithelialization were measured. Animals were sacrificed 21 days after wounding. Samples of lesion and normal tissue were formalin-fixed, paraffin embedded for histological analysis. RESULTS: Wound contraction, measured 14 and 21 days after wounding, was greater in the GSNO group than in the control group (P<0.05 for both). The re-epithelialized wound area, measured 14 days after wounding, was higher in the GSNO group than in the control group (P<0.05). A higher amount of inflammatory cells was observed in superficial and deep areas of the granulation tissue of the control group compared to the GSNO group. Twenty-one days after wounding, thin red-yellow collagen fibers arranged perpendicularly to the surface were found in the granulation tissue of the control group, whereas in the GSNO-treated group collagen fibers were thicker and arranged parallel to the surface. Increased number of mast cells was observed in the GSNO group compared with that in the control group. Vascularization and myofibroblast distribution were similar in both groups. CONCLUSION: Topical application of GSNO-containing hydrogel during the early phases of rat cutaneous wound repair accelerates wound closure and re-epithelialization and affects granulation tissue organization. 相似文献
2.
D. J. Shanley 《Neuroradiology》1992,35(1):55-56
Summary A patient with symptomatic bilateral aberrant cervical internal carotid arteries, demonstrated on CT and MRI, is described. 相似文献
3.
A mesenteric cyst with milk of calcium in an adult patient is presented. Preoperative evaluation included plain film, ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI). To our knowledge, the presence of milk of calcium in a mesenteric cyst has not been previously described. 相似文献
4.
5.
6.
7.
Guidot David M. Linas Stuart L. Repine Michael J. Shanley Paul F. Fisher Halee S. Repine John E. 《Inflammation》1994,18(5):537-545
Hearts from rats treated with interleukin-1 (IL-1) intraperitoneally developed a rapid (6 h after IL-1), transient increase in neutrophils, tissue hydrogen peroxide (H2O2), and oxidized glutathione (GSSG) levels, and a subsequent (36 h after IL-1) increase in myocardial glucose-6-phosphate dehydrogenase (G6PD) activity and tolerance to ischemia-reperfusion. In the present investigation, we found that rats treated similarly with IL-1 had increased numbers of neutrophils in their kidneys, which were comparable to myocardial neutrophil increases, but did not develop increased renal tissue H2O2 or GSSG levels acutely (6 h after IL-1) or increased G6PD activity or resistance to ischemia-reperfusion injury later (36 h after IL-1). Our findings indicate that IL-1 treatment increased neutrophil accumulation in rat kidneys but did not increase oxidative stress, antioxidant enzyme activity, or resistance to ischemia-reperfusion injury. We conclude that organ-to-organ differences exist with respect to IL-1-induced tolerance. 相似文献
8.
9.
Regulatory effects of interleukin-6 in immunoglobulin G immune-complex-induced lung injury. 总被引:2,自引:0,他引:2
下载免费PDF全文
![点击此处可从《The American journal of pathology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
T. P. Shanley J. L. Foreback D. G. Remick T. R. Ulich S. L. Kunkel P. A. Ward 《The American journal of pathology》1997,151(1):193-203
Interleukin-6 (IL-6) is a cytokine produced in response to a variety of inflammatory stimuli. Although IL-6 is often observed in increased amounts in acute respiratory distress syndrome, its role in the development of lung injury is unclear. The role of IL-6 was studied in the rat model of lung injury induced by the intra-alveolar deposition of IgG immune complexes. IL-6 induction, as determined by Northern blot analysis and bioactivity, was found as a function of time during the course of development of injury. Recombinant IL-6 instilled intratracheally at commencement of injury led to substantial reductions in lung vascular permeability, neutrophil accumulation, and levels of tumor necrosis factor (TNF)-alpha and macrophage inflammatory protein (MIP)-2 in bronchoalveolar lavage fluids. Conversely, blocking of intrinsic IL-6 by a neutralizing antibody resulted in increases in lung vascular permeability, neutrophil content, and TNF-alpha levels in bronchoalveolar lavage fluids. Rat alveolar macrophages stimulated in vitro with lipopolysaccharide in the presence of IL-6 showed a significant reduction in TNF-alpha expression. Together, these findings suggest that IL-6 acts as an intrinsic regulator of lung inflammatory injury after deposition of IgG immune complexes and that the protective effects of exogenously administered IL-6 may be in part linked to suppressed TNF-alpha production. 相似文献
10.
Stein TP; Oram-Smith JC; Leskiw MJ; Wallace HW; Long LC; Leonard JM 《The American journal of physiology》1976,230(5):1321-1325