全文获取类型
收费全文 | 1686篇 |
免费 | 75篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 43篇 |
儿科学 | 88篇 |
妇产科学 | 47篇 |
基础医学 | 213篇 |
口腔科学 | 54篇 |
临床医学 | 152篇 |
内科学 | 398篇 |
皮肤病学 | 56篇 |
神经病学 | 110篇 |
特种医学 | 178篇 |
外科学 | 192篇 |
综合类 | 29篇 |
预防医学 | 66篇 |
眼科学 | 8篇 |
药学 | 92篇 |
中国医学 | 1篇 |
肿瘤学 | 44篇 |
出版年
2021年 | 26篇 |
2020年 | 16篇 |
2019年 | 14篇 |
2018年 | 21篇 |
2017年 | 13篇 |
2015年 | 22篇 |
2014年 | 40篇 |
2013年 | 34篇 |
2012年 | 54篇 |
2011年 | 43篇 |
2010年 | 43篇 |
2009年 | 58篇 |
2008年 | 59篇 |
2007年 | 58篇 |
2006年 | 44篇 |
2005年 | 48篇 |
2004年 | 46篇 |
2003年 | 57篇 |
2002年 | 40篇 |
2001年 | 54篇 |
2000年 | 54篇 |
1999年 | 50篇 |
1998年 | 33篇 |
1997年 | 44篇 |
1996年 | 53篇 |
1995年 | 37篇 |
1994年 | 29篇 |
1993年 | 45篇 |
1992年 | 26篇 |
1991年 | 25篇 |
1990年 | 36篇 |
1989年 | 33篇 |
1988年 | 42篇 |
1987年 | 41篇 |
1986年 | 33篇 |
1985年 | 37篇 |
1984年 | 20篇 |
1983年 | 19篇 |
1982年 | 25篇 |
1981年 | 18篇 |
1980年 | 19篇 |
1979年 | 37篇 |
1978年 | 23篇 |
1977年 | 18篇 |
1976年 | 19篇 |
1975年 | 12篇 |
1970年 | 16篇 |
1969年 | 12篇 |
1968年 | 11篇 |
1966年 | 12篇 |
排序方式: 共有1771条查询结果,搜索用时 15 毫秒
1.
D Gröne† R Treudler† EM de Villiers‡ R Husak† CE Orfanos† ChC Zouboulis†§ 《Journal of the European Academy of Dermatology and Venereology》2006,20(2):202-205
Cidofovir is an acyclic nucleoside phosphonate with broad-spectrum activity against DNA viruses, including human papilloma virus (HPV). However, data on the efficacy of cidofovir in an immunosuppressive setting remain contradictory. We report for the first time on the promotion of the healing of recalcitrant warts in a patient with myelodysplastic syndrome with intravenous cidofovir treatment. 相似文献
2.
W J Scott C A Duggan C M Schreiner M D Collins 《Toxicology and applied pharmacology》1990,103(2):238-254
The effects of acetazolamide on the developing rodent limb bud were postulated to result from a reduction of intracellular pH (pHi). Embryonic intracellular pH was calculated from transplacental distribution of the weak acid, 5,5'-dimethyloxazolidine-2,4-dione, in teratogenically sensitive (C57BL/6) and resistant (SWV) inbred mice. pHi was reduced by acetazolamide treatment in C57 embryos and limb buds but not in SWV samples. Acetazolamide teratogenesis can be exacerbated by coadministration of amiloride, presumably through inhibition of Na+/H+ exchange attributable to the latter agent. pHi reduction after such treatment was more profound than after acetazolamide alone, providing further support for the central hypothesis. pH was also reduced in other embryonic (embryo plasma) and extraembryonic compartments (exocoelomic fluid, amniotic fluid). pH changes in these compartments could also lead or contribute to abnormal development. 相似文献
3.
4.
A. Ring V. Schreiner H. Wenck K. P. Wittern L. Küpper R. Keyhani 《Skin research and technology》2006,12(1):18-23
Background/aim: Mid-infrared spectroscopy is a versatile method for in vivo investigation of skin after topical treatment with skin care products.
Methods: FTIR-spectrometer (Bruker Optics) with a flexible silver halide fibre probe (Infrared Fiber Sensors).
Results: Absorbance spectra from 700 to 3000 cm−1 have been recorded to gain information about proteins (amide-I and amide-II vibrations at 1650 and 1550 cm−1 ), esters (1740 cm−1 ), carboxylic acid (1710 cm−1 ), polyalcohols (1050 cm−1 ) and hydrocarbons (CH n vibrations at 2800–3000 cm−1 ).
Conclusions: Using the particular light guide, we were able to measure for the first time the effects of lip care products on lips directly. Furthermore, water binding and glycerol content of the skin could be determined simultaneously, as well as the replenishment of lipids by lipid-enriched bath oil. 相似文献
Methods: FTIR-spectrometer (Bruker Optics) with a flexible silver halide fibre probe (Infrared Fiber Sensors).
Results: Absorbance spectra from 700 to 3000 cm
Conclusions: Using the particular light guide, we were able to measure for the first time the effects of lip care products on lips directly. Furthermore, water binding and glycerol content of the skin could be determined simultaneously, as well as the replenishment of lipids by lipid-enriched bath oil. 相似文献
5.
To ascertain the potential role of reactive oxygen metabolites in the pathophysiology of obstructive uropathy, we examined the effect of probucol, an antioxidant agent, on renal function in normal rats and rats with unilateral release of bilateral ureteral obstruction (BUO) of 24 hours duration. Rats were fed either a standard diet or a standard diet containing one percent probucol for two weeks prior to study. Probucol lowered serum cholesterol in both normal and BUO rats. Probucol did not significantly affect renal function in normal rats. BUO rats given probucol had greater inulin and PAH clearances at three to five hours and three days following release of BUO than rats with BUO not given probucol. Kidneys from obstructed rats had higher levels of malondialdehyde, an index of lipid peroxidation, a greater number of leukocytes in the cortex, decreased levels of reduced glutathione and increased levels of oxidized glutathione. Renal cortex from obstructed rats treated with probucol had significantly higher levels of reduced glutathione than kidneys of obstructed rats not given probucol. A decrease in cholesterol, using another lipid-lowering agent, lovastatin, did not modify renal function in rats with BUO. The data can be interpreted to indicate a role for reactive oxygen species in the pathophysiology of obstructive nephropathy. The improved renal function seen in probucol-treated rats with BUO may be due to an effect of this agent in affecting accumulation of reactive oxygen metabolites and/or decreasing the number of leukocytes infiltrating the renal cortex. 相似文献
6.
7.
8.
9.
Digital radiography of subtle pulmonary abnormalities: an ROC study of the effect of pixel size on observer performance 总被引:3,自引:0,他引:3
Forty conventional radiographs with examples of mild interstitial infiltrates and subtle pneumothoraces and 40 normal studies of the chest were selected and digitized, with pixel sizes of 1.0, 0.5, 0.2, and 0.1 mm. Observer performance tests were carried out using receiver operating characteristic analysis. Conventional radiographs and digitized images were compared. The results indicate that, in such cases, diagnostic accuracy increases significantly as the pixel size is reduced, at least to the 0.1-mm level. We conclude that, for digital systems using screen-film or similar image receptors, use of a pixel size substantially larger than 0.1 mm may result in some loss of diagnostic accuracy. 相似文献