全文获取类型
收费全文 | 735篇 |
免费 | 35篇 |
国内免费 | 2篇 |
专业分类
儿科学 | 4篇 |
妇产科学 | 174篇 |
基础医学 | 68篇 |
临床医学 | 69篇 |
内科学 | 139篇 |
皮肤病学 | 2篇 |
神经病学 | 21篇 |
特种医学 | 20篇 |
外科学 | 61篇 |
综合类 | 2篇 |
预防医学 | 160篇 |
眼科学 | 3篇 |
药学 | 35篇 |
肿瘤学 | 14篇 |
出版年
2021年 | 9篇 |
2016年 | 6篇 |
2015年 | 8篇 |
2014年 | 9篇 |
2013年 | 19篇 |
2012年 | 18篇 |
2011年 | 15篇 |
2010年 | 15篇 |
2009年 | 10篇 |
2008年 | 15篇 |
2007年 | 19篇 |
2006年 | 18篇 |
2005年 | 19篇 |
2004年 | 18篇 |
2003年 | 24篇 |
2002年 | 13篇 |
2001年 | 22篇 |
2000年 | 22篇 |
1999年 | 31篇 |
1998年 | 12篇 |
1997年 | 16篇 |
1996年 | 11篇 |
1995年 | 29篇 |
1994年 | 10篇 |
1993年 | 12篇 |
1992年 | 21篇 |
1991年 | 15篇 |
1990年 | 16篇 |
1989年 | 24篇 |
1988年 | 13篇 |
1987年 | 20篇 |
1986年 | 21篇 |
1985年 | 18篇 |
1984年 | 14篇 |
1983年 | 14篇 |
1982年 | 12篇 |
1981年 | 10篇 |
1980年 | 12篇 |
1979年 | 13篇 |
1978年 | 8篇 |
1977年 | 7篇 |
1976年 | 6篇 |
1975年 | 18篇 |
1973年 | 12篇 |
1972年 | 10篇 |
1971年 | 11篇 |
1970年 | 7篇 |
1969年 | 13篇 |
1967年 | 8篇 |
1960年 | 5篇 |
排序方式: 共有772条查询结果,搜索用时 15 毫秒
1.
Michael Schenker Mikael Wiberg Simon P Kay Roland S Johansson 《Journal of plastic, reconstructive & aesthetic surgery》2007,60(1):13-23
Although toe-to-hand transfer has a defined role in the management of congenital hand deformities, it remains unclear how well children integrate the transferred digits into physiological grasping. We analysed fingertip forces in the precision grip of 13 patients when lifting a test object more than three years after free toe transfer for absent or hypoplastic digits. Clinically, most patients showed normal sensibility of transferred digits, but active motion and pinch strength were limited as compared to the normal hand. For the control of fingertip forces, two key features of the normal two-digit opposition grip were seen in all operated hands: adaptation of grip force to object weight and parallel coordination of lift and grip forces. These physiological grasping strategies developed independently of the patients' age at the time of operation, which ranged from one to 13 years. In four patients, we observed increased tangential load forces with the operated hand due to misalignments in the application of fingertips on the grasp surfaces. Such forces lead to increased grip force requirements on both fingers that may overload transferred digits with limited motor function. The need for optimal alignment of the grip axis during toe-transfer surgery is emphasised. 相似文献
2.
Two thousand nine hundred and ninety-four reports of OSHA-reportable occupational injury or illness cases in 1984 from member companies of a national trade association of semiconductor manufacturing firms were analyzed. The 37 participating manufacturing facilities represented 16 companies employing over 95,000 persons, or approximately one-third of the U.S. work force for this industry in 1984. The annual incidence rate for all reportable injuries and illnesses was 2.7 per 100 full-time employees (FTE) for men and 3.7 per 100 FTE for women. Strains, sprains, or dislocations were the most frequently reported incidents (N = 956 [31.9%]), followed by cuts, lacerations, punctures, scratches, and abrasions (N = 445 [14.9%]), and chemical burns (N = 401 [13.4%]). Increased work-loss days per case were associated with manufacturing sites that did not have an employee health clinic on the premises, with custodial occupations, and with female gender. 相似文献
3.
A Birkenfeld D Navot Y Ezra A Ron J G Schenker 《European journal of obstetrics, gynecology, and reproductive biology》1987,25(3):221-229
The effect of estradiol valerate and allylestrenol on the endometrial transformation of five hypergonadotropic hypogonadic women was evaluated. Estradiol valerate was administered throughout the whole induced cycle (28 days), while allylestrenol was added during the second half of the cycle. Endometrial biopsies were performed during allylestrenol treatment and were evaluated histologically. Samples of endometrium were also subjected to one-dimensional SDS electrophoresis. Of ten biopsies performed, only one was interpreted to be in-phase, while the others were dated proliferative (4 biopsies) or showed abortive or out-of-phase secretory transformation. The highest mean serum progesterone level, detected under allylestrenol treatment, was 1.5 ng/ml. Protein electrophoresis demonstrated relative sequential changes in the protein patterns of the 115 kDa and 150 kDa protein bands. It is concluded that allylestrenol, although having gestagen properties, may not be efficient for the induction of an adequate secretory transformation of human endometrium in the absence of ovaries. 相似文献
4.
HELLP syndrome--a syndrome of hemolysis, elevated liver enzymes and low platelet count--complicating preeclampsia-eclampsia. 总被引:2,自引:0,他引:2
The course of preeclamptic/eclamptic patients may be complicated by HELLP syndrome, a syndrome of intravascular hemolysis (H), elevated liver enzymes (EL) and low platelet count (LP). These patients typically present at early third trimester with epigastric or right upper quadrant pain, nausea and vomiting. They may present without the clinical signs of preeclampsia (hypertension and proteinuria or edema), thus an initial wrong nonobstetric diagnosis is not uncommon. The most frequent maternal complication is intravascular coagulopathy (30%). Placental abruption and acute renal failure are also common. Ten cases of maternal deaths were reported among 295 cases reviewed in the English language literature, while the perinatal mortality rate was 226/1000. The grave prognosis for mother and fetus warrants physician awareness in order to accomplish early diagnosis and proper management. This paper is a review of the literature in English. 相似文献
5.
Lynn R. Sorbara Zhichun Tang Alessandro Cama Jinru Xia Esther Schenker Ronald A. Kohanski Leonid Poretsky Elizabeth Koller Simeon I. Taylor Andrea Dunaif 《Metabolism: clinical and experimental》1994,43(12)
Women with polycystic ovary syndrome (PCOS) are markedly insulin-resistant, but the molecular mechanisms of these changes and their relationship to the hyperandrogenic state remain to be clarified. Mutations have recently been identified in the insulin receptor gene of patients with extreme forms of insulin resistance associated with hyperandrogenism (eg, type A insulin resistance), and these mutations account for the insulin resistance in such patients. We performed this study to determine whether mutations in the coding portion of the insulin receptor gene were responsible for insulin resistance in PCOS. Insulin binding studies using cultured skin fibroblasts of three obese (body mass index > 27 kg/m2) women with PCOS (ie, mild hyperandrogenemia and chronic anovulation of unknown etiology) and documented insulin resistance showed no apprarent abnormalities in either the number or affinity of insulin binding sites. Direct sequencing of all 22 exons of the insulin receptor gene from two of the women with PCOS did not reveal any mutations. Furthermore, both alleles of the gene were expressed at equal levels. In a third insulin-resistant PCOS woman, there was no evidence for a mutation in the coding portion of the insulin receptor gene as determined by denaturing gradient gel electrophoresis (DGGE). We conclude that the insulin resistance in these PCOS women was caused by a defect extrinsic to the insulin receptor. 相似文献
6.
Marc Philippon Mara Schenker Karen Briggs David Kuppersmith 《Knee surgery, sports traumatology, arthroscopy》2007,15(7):908-914
Femoroacetabular impingement (FAI) occurs when an osseous abnormality of the proximal femur (cam) or acetabulum (pincer) triggers
damage to the acetabular labrum and articular cartilage in the hip. Although the precise etiology of FAI is not well understood,
both types of FAI are common in athletes presenting with hip pain, loss of range-of-motion, and disability in athletics. An
open surgical approach to decompressing FAI has shown good clinical outcomes; however, this highly invasive approach inherently
may delay or preclude a high level athlete’s return to play. The purpose of this study was to define associated pathologies
and determine if an arthroscopic approach to treating FAI can allow professional athletes to return to high-level sport. Hip
arthroscopy for the treatment of FAI allows professional athletes to return to professional sport. Between October 2000 and
September 2005, 45 professional athletes underwent hip arthroscopy for the decompression of FAI. Operative and return-to-play
data were obtained from patient records. Average time to follow-up was 1.6 years (range: 6 months to 5.5 years). Forty two
(93%) athletes returned to professional competition following arthroscopic decompression of FAI. Three athletes did not return
to play; however, all had diffuse osteoarthritis at the time of arthroscopy. Thirty-five athletes (78%) remain active in professional
sport at an average follow-up of 1.6 years. Arthroscopic treatment of FAI allows professional athletes to return to professional
sport. 相似文献
7.
8.
The latest remarkable technological advances in assisted reproduction,
which enable cryopreservation of spermatozoa, embryos and ovarian tissue,
raise difficult and debatable legal, social, ethical and moral issues
concerning the right to posthumous reproduction. Furthermore, reports on
the attitudes of the general public and of centres licensed for infertility
treatment in the United Kingdom found that the majority of women and
centres support the idea of posthumous reproduction. In this paper we
review the data published on this issue, and after considering the various
aspects, we conclude that each case should be discussed and authorized by a
multidisciplinary committee that includes physicians, clergy,
psychiatrists, psychologists, sociologists and other appropriate parties.
In our opinion, the main principles that should guide this committee would
allow posthumous reproduction in the context of marriage when a prior
consent exists. For unmarried persons, post-mortem donation of gametes
should be done only anonymously, if they are in agreement with existing
laws concerning infertility treatments in every country and after
appropriate consent and proper counselling. Moreover, any case which
involves consanguinity or a possibility of incest should be forbidden, both
for ethical and genetic reasons. In a case of pre-existing siblings, they
should be consulted and their informed consent should be granted in advance
so as to avoid legal problems in the inheritance of property.
相似文献
9.
Preimplantation genetic diagnosis principles and ethics 总被引:4,自引:0,他引:4
10.
Endocrinology: The effect of growth hormone on granulosa cell function during in-vitro fertilization
Younis J.S.; Ezra Y.; Brzezinnski A.; Fibich T.; Schenker J.G.; Laufer N. 《Human reproduction (Oxford, England)》1993,8(10):1588-1592
The effect of growth hormone addition to human menopausal gonadotrophin(HMG), after pituitary down-regulation, on granulosa cell function,in in-vitro fertilization (IVF) was evaluated. Growth hormoneor placebo were added in a prospective, randomized and double-blindmanner to an existing IVF stimulation protocol. Forty-two normalovulatory women (38 years old) with mechanical factor infertilityand normal male factor were included in the study. Gonadotrophin-releasinghormone agonist (GnRHa) was given from day 21 of the previouscycle until human chorionic gonadotrophin (HCG) administration.Follicular stimulation with HMG was started after pituitarydown-regulation. Growth hormone 12 IU/day or placebo were administeredon alternate days, beginning day 1 until day 7 of HMG treatment.Granulosa cell function was evaluated, in all patients, by follicularfluid levels of ovarian steroids and insulin-like growth factor-I(IGF-I). In 14 patients, chosen arbitrarily granulosa luteincells were cultured in the presence and absence of additionalHCG. Follicular fluid levels of oestradiol, progesterone, testosteroneand IGF-I were similar in both growth hormone and placebo groups.Basal and post-HCG levels of oestradiol and progesterone didnot differ significantly between the two groups of granulosalutein cell cultures. We conclude that after pituitary down-regulation,in-vivo administration of growth hormone with HMG in young ovulatorywomen does not seem to affect granulosa cell function when comparedto the administration of HMG alone. 相似文献