首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   1478529篇
  免费   107284篇
  国内免费   6797篇
耳鼻咽喉   17702篇
儿科学   47220篇
妇产科学   42427篇
基础医学   212447篇
口腔科学   39797篇
临床医学   141250篇
内科学   292588篇
皮肤病学   33658篇
神经病学   124330篇
特种医学   54167篇
外国民族医学   369篇
外科学   207389篇
综合类   30773篇
现状与发展   1篇
一般理论   533篇
预防医学   126336篇
眼科学   30701篇
药学   106699篇
  6篇
中国医学   3337篇
肿瘤学   80880篇
  2021年   14839篇
  2019年   14961篇
  2018年   18070篇
  2017年   14540篇
  2016年   15911篇
  2015年   18100篇
  2014年   24274篇
  2013年   37062篇
  2012年   46668篇
  2011年   49704篇
  2010年   30372篇
  2009年   29034篇
  2008年   45221篇
  2007年   47421篇
  2006年   48364篇
  2005年   46609篇
  2004年   44289篇
  2003年   42739篇
  2002年   41119篇
  2001年   63965篇
  2000年   65074篇
  1999年   55242篇
  1998年   17556篇
  1997年   16079篇
  1996年   15940篇
  1995年   15850篇
  1994年   14791篇
  1993年   13747篇
  1992年   44850篇
  1991年   43967篇
  1990年   42253篇
  1989年   40270篇
  1988年   37158篇
  1987年   36378篇
  1986年   34753篇
  1985年   33371篇
  1984年   25547篇
  1983年   21982篇
  1982年   13840篇
  1981年   12435篇
  1979年   22600篇
  1978年   16594篇
  1977年   13798篇
  1976年   13242篇
  1975年   13544篇
  1974年   15954篇
  1973年   15546篇
  1972年   14277篇
  1971年   13246篇
  1970年   12253篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
6.
7.
8.
Objectives: The steeling effect suggests that early-life adversity can have a beneficial impact later in life. However, little is known about its underlying mechanisms and long-term outcomes . The study aimed to examine the role of early-life adversity (ELA) on successful aging, and whether this relationship can be explained by mental and physical health.

Method: Socio-demographics, early-life adversity (ELA), individual quality of life (iQoL), and mental and physical health of 270 individuals (Mage = 66.82 years, 71.5% female) were assessed. Polynomial regressions and mediation analyses were conducted.

Results: Significant inverse U-shaped associations were found between ELA and iQoL (β = ?.59, p = .005) and between ELA and mental health (β = ?.64, p = .002), but not between ELA and physical health. Furthermore, mental health significantly mediated the relationship between ELA and iQoL (b = ?.84, BCa CI [?1.66, ?.27]).

Conclusion: Highest level of individual quality of life (i.e. successful aging) was related to a moderate amount of ELA. Additionally, mental health significantly mediated this relationship. These findings suggest that some amount of ELA could be beneficial for successful aging. Resource-focused interventions are needed to improve health and promote successful aging for an underdetected, at-risk subgroup with low early-life adversity.  相似文献   

9.
Abstract

Objectives: This study examined word use as an indicator of interpersonal positive reframing in daily conversations of couples coping with breast cancer and as a predictor of stress.

Design: The Electronically Activated Recorder (EAR) and Linguistic Inquiry and Word Count (LIWC) were used to examine naturally occurring word use conceptually linked to positive reframing (positive emotion, negative emotion, and cognitive processing words).

Sample: Fifty-two couples coping with breast cancer.

Methods: Couples wore the EAR, a device participants wear, that audio-recorded over one weekend (>16,000 sound files), and completed self-reports of positive reframing (COPE) and stress (Perceived Stress Scale). LIWC, a software program, measured word use.

Findings: Both partners’ word use (i.e., positive emotion and cognitive processing words) was associated with their own reported positive reframing, and spouses’ word use was also indicative of patients’ positive reframing. Results also revealed that, in general, words indicating positive reframing predicted lower levels of stress.

Conclusions: Findings supported the hypothesis that partners—and particularly spouses of breast cancer patients—may assist each other’s coping by positively reframing the cancer experience and other negative experiences in conversation.  相似文献   
10.

Background

Rosacea is a chronic inflammatory skin condition whose etiology has been linked to mast cells and the antimicrobial peptide cathelicidin LL-37. Individuals with refractory disease have demonstrated clinical benefit with periodic injections of onabotulinum toxin, but the mechanism of action is unknown.

Objectives

To investigate the molecular mechanism by which botulinum toxin improves rosacea lesions.

Methods

Primary human and murine mast cells were pretreated with onabotulinum toxin A or B or control. Mast cell degranulation was evaluated by β-hexosaminidase activity. Expression of botulinum toxin receptor Sv2 was measured by qPCR. The presence of SNAP-25 and VAMP2 was established by immunofluorescence. In vivo rosacea model was established by intradermally injecting LL-37 with or without onabotulinum toxin A pretreatment. Mast cell degranulation was assessed in vivo by histologic counts. Rosacea biomarkers were analyzed by qPCR of mouse skin sections.

Results

Onabotulinum toxin A and B inhibited compound 48/80-induced degranulation of both human and murine mast cells. Expression of Sv2 was established in mouse mast cells. Onabotulinum toxin A and B increased cleaved SNAP-25 and decreased VAMP2 staining in mast cells respectively. In mice, injection of onabotulinum toxin A significantly reduced LL-37-induced skin erythema, mast cell degranulation, and mRNA expression of rosacea biomarkers.

Conclusions

These findings suggest that onabotulinum toxin reduces rosacea-associated skin inflammation by directly inhibiting mast cell degranulation. Periodic applications of onabotulinum toxin may be an effective therapy for refractory rosacea and deserves further study.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号