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排序方式: 共有49条查询结果,搜索用时 31 毫秒
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Afak Yusuf Sherwani Abdul Qayoom Shah Abdul Majeed Wani Ahmad Chalkoo Bashir Ahmad Khan Bashir Farooq Ahmad Sofi Ashfaq Amin Wani Wasim Lone Ab Hamid Sherwani Mehmood Rashid Sheikh Raj Reshi Sharma 《International journal of surgery case reports》2014,5(12):1285-1287
INTRODUCTION
Persistent Mullerian duct syndrome is a rare form of male pseudo-hermaphroditism characterized by the presence of Mullerian duct structures in an otherwise phenotypically, as well as genotypically, normal man; only a few cases have been reported in the worldwide literature. A great variety of organs have been found in indirect inguinal hernial sacs.PRESENTATION OF CASE
We report a case of 70 year old man, father of 4 children with unilateral cryptorchidism on the right side and left-sided obstructed inguinal hernia containing uterus and fallopian tube (that is, hernia uteri inguinalis; type I male form of persistent Mullerian duct syndrome) coincidentally detected during an operation for an obstructed left inguinal hernia.DISCUSSION
PMDS is usually coincidently detected during surgical operation, as was in our case. However pre-operative ultrasonography, computerized tomography and MRI allow possible pre-operative diagnosis.3CONCLUSION
In cases of unilateral or bilateral cryptorchidism associated with hernia, as in our patient''s case, the possibility of PMDS should be kept in mind. 相似文献3.
Mohd Salim Reshi Sadhana Shrivastava Amita Jaswal Neelu Sinha Chhavi Uthra Sangeeta Shukla 《Experimental and toxicologic pathology》2017,69(4):231-240
Valuable effects of gold particles have been reported and used in complementary medicine for decades. The aim of this study was to evaluate the therapeutic efficacy of gold nanoparticles (AuNPs) against acetaminophen (APAP) induced toxicity. Albino rats were administered APAP at a dose of 2 g/kg p.o. once only. After 24 h of APAP intoxication, animals were treated with three different doses of AuNPs (50 μg/kg, 100 μg/kg, 150 μg/kg) orally or silymarin at a dose of 50 mg/kg p.o., once only. Animals of all the groups were sacrificed after 24 h of last treatment. APAP administered group showed a significant rise in the AST, ALT, SALP, LDH, cholesterol, bilirubin, albumin, urea and creatinine in serum which indicated the hepato-renal damage. A significantly enhanced LPO and a depleted level of GSH were observed in APAP intoxicated rats. Declined activities of SOD and Catalase, after acetaminophen exposure indicated oxidative stress in liver and kidney. The activities of ATPase and glucose-6-Phosphatase were significantly inhibited after APAP administration. AuNPs treatment reversed all variables significantly towards normal level and was found nontoxic. Thus it is concluded that gold nanoparticles played a beneficial role in reducing acetaminophen induced toxicity and can be used in the development of drug against hepatic as well as renal diseases, after further preclinical and clinical studies. 相似文献
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Donald R. Ort Sabeeha S. Merchant Jean Alric Alice Barkan Robert E. Blankenship Ralph Bock Roberta Croce Maureen R. Hanson Julian M. Hibberd Stephen P. Long Thomas A. Moore James Moroney Krishna K. Niyogi Martin A. J. Parry Pamela P. Peralta-Yahya Roger C. Prince Kevin E. Redding Martin H. Spalding Klaas J. van Wijk Wim F. J. Vermaas Susanne von Caemmerer Andreas P. M. Weber Todd O. Yeates Joshua S. Yuan Xin Guang Zhu 《Proceedings of the National Academy of Sciences of the United States of America》2015,112(28):8529-8536
The world’s crop productivity is stagnating whereas population growth, rising affluence, and mandates for biofuels put increasing demands on agriculture. Meanwhile, demand for increasing cropland competes with equally crucial global sustainability and environmental protection needs. Addressing this looming agricultural crisis will be one of our greatest scientific challenges in the coming decades, and success will require substantial improvements at many levels. We assert that increasing the efficiency and productivity of photosynthesis in crop plants will be essential if this grand challenge is to be met. Here, we explore an array of prospective redesigns of plant systems at various scales, all aimed at increasing crop yields through improved photosynthetic efficiency and performance. Prospects range from straightforward alterations, already supported by preliminary evidence of feasibility, to substantial redesigns that are currently only conceptual, but that may be enabled by new developments in synthetic biology. Although some proposed redesigns are certain to face obstacles that will require alternate routes, the efforts should lead to new discoveries and technical advances with important impacts on the global problem of crop productivity and bioenergy production. 相似文献
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Persistent false serology for kala-azar using the indirect haemagglutination technique is described in two patients. One patient had Behcet's disease and the other infective endocarditis. 相似文献
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Vishwas Mishra Avipsa Bose Shashi Kiran Sanghita Banerjee Idrees A. Shah Pooja Chaukimath Mudasir M. Reshi Swarna Srinivas Anaxee Barman Sandhya S. Visweswariah 《The Journal of experimental medicine》2021,218(11)
Activating mutations in receptor guanylyl cyclase C (GC-C), the target of gastrointestinal peptide hormones guanylin and uroguanylin, and bacterial heat-stable enterotoxins cause early-onset diarrhea and chronic inflammatory bowel disease (IBD). GC-C regulates ion and fluid secretion in the gut via cGMP production and activation of cGMP-dependent protein kinase II. We characterize a novel mouse model harboring an activating mutation in Gucy2c equivalent to that seen in an affected Norwegian family. Mutant mice demonstrated elevated intestinal cGMP levels and enhanced fecal water and sodium content. Basal and linaclotide-mediated small intestinal transit was higher in mutant mice, and they were more susceptible to DSS-induced colitis. Fecal microbiome and gene expression analyses of colonic tissue revealed dysbiosis, up-regulation of IFN-stimulated genes, and misregulation of genes associated with human IBD and animal models of colitis. This novel mouse model thus provides molecular insights into the multiple roles of intestinal epithelial cell cGMP, which culminate in dysbiosis and the induction of inflammation in the gut. 相似文献