全文获取类型
收费全文 | 693篇 |
免费 | 34篇 |
国内免费 | 61篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 41篇 |
妇产科学 | 26篇 |
基础医学 | 76篇 |
口腔科学 | 19篇 |
临床医学 | 93篇 |
内科学 | 149篇 |
皮肤病学 | 11篇 |
神经病学 | 25篇 |
特种医学 | 88篇 |
外科学 | 70篇 |
综合类 | 56篇 |
一般理论 | 2篇 |
预防医学 | 33篇 |
眼科学 | 12篇 |
药学 | 55篇 |
中国医学 | 1篇 |
肿瘤学 | 21篇 |
出版年
2021年 | 8篇 |
2017年 | 5篇 |
2016年 | 5篇 |
2015年 | 11篇 |
2014年 | 8篇 |
2013年 | 12篇 |
2012年 | 9篇 |
2011年 | 7篇 |
2010年 | 18篇 |
2009年 | 25篇 |
2008年 | 4篇 |
2007年 | 45篇 |
2006年 | 14篇 |
2005年 | 14篇 |
2004年 | 4篇 |
2002年 | 8篇 |
2001年 | 6篇 |
2000年 | 10篇 |
1999年 | 17篇 |
1998年 | 34篇 |
1997年 | 44篇 |
1996年 | 32篇 |
1995年 | 26篇 |
1994年 | 15篇 |
1993年 | 27篇 |
1992年 | 6篇 |
1991年 | 11篇 |
1990年 | 9篇 |
1989年 | 23篇 |
1988年 | 12篇 |
1987年 | 11篇 |
1986年 | 7篇 |
1985年 | 9篇 |
1984年 | 10篇 |
1983年 | 8篇 |
1982年 | 7篇 |
1981年 | 9篇 |
1980年 | 17篇 |
1978年 | 4篇 |
1976年 | 4篇 |
1975年 | 4篇 |
1959年 | 14篇 |
1958年 | 44篇 |
1957年 | 23篇 |
1956年 | 21篇 |
1955年 | 33篇 |
1954年 | 26篇 |
1949年 | 6篇 |
1948年 | 15篇 |
1947年 | 6篇 |
排序方式: 共有788条查询结果,搜索用时 15 毫秒
1.
The initial management of bladder outflow obstruction typically related to benign prostatic hyperplasia (BPH) falls to a large extent within the remit of general practice. Referral onwards to secondary care typically arises following the failure to respond to conservative measures or when complications have supervened; the most significant of which is urinary retention. In the hospital setting, anaesthesia, constipation and immobility are the common precipitants. What follows is a practical guide to the management of these situations and provides an overview of the conservative, medical, minimally invasive and surgical treatments available. 相似文献
2.
3.
4.
M. KROTKIEWSKI L. SJ
STR
M L. SULLIVAN P.-A. LUNDBERG G. LINDSTEDT H. WETTERQVIST P. BJ
RNTORP 《Journal of internal medicine》1984,216(3):269-275
Abstract Thyroid hormones were measured before, during and after acute exercise (60 min) or physical training (3 months) in obese women. Thyroid stimulating hormone concentration increased during acute work and decreased immediately after. No changes were seen during the two following days. An increase was seen after ten days as well as after three months of physical training. Thyroxine concentrations showed no changes. 3,5,3′-Triiodothyronine decreased slightly immediately after acute exercise, and after three months of physical training, 3,3′,5′-triiodothyronine (reverse triiodothyronine) increased slowly during and after acute exercise. A negative correlation was found between changes in fasting insulin and thyroxine and a positive correlation between changes in blood pressure and triiodothyronine after training. Lack of agreement in previous reports is probably due to methodological differences such as methods more or less susceptible to fatty acid interference, and thyroid hormones changing differently during acute work and before and after physical training. The duration of the study may also be of importance, even 3 months possibly being too short for attaining equilibrium in thyroid homeostasis. 相似文献
5.
Background
There is currently an unprecedented expressed need and demand for estimates of maternal mortality in developing countries. This has been stimulated in part by the creation of a Millennium Development Goal that will be judged partly on the basis of reductions in maternal mortality by 2015. 相似文献6.
7.
8.
Cytokine responses to the native and recombinant forms of the major surface glycoprotein of Pneumocystis carinii 下载免费PDF全文
S A THEUS A G SMULIAN D W SULLIVAN P D WALZER 《Clinical and experimental immunology》1997,109(2):255-260
Pneumocystis carinii is a major opportunistic pathogen and leading cause of morbidity in patients with AIDS. The major surface glycoprotein (MSG) of P. carinii, represented by a family of related proteins encoded by unique genes, is highly immunogenic and contains T cell-protective epitopes. We undertook the present study to define the CD4 T helper (Th) response by cytokine secretion to native MSG and a recombinant form of the protein, MSG-B. Spleen cells were collected from Lewis rats and restimulated with both native MSG and MSG-B. Within 24 h, the CD4 cells secreted high levels of interferon-gamma (IFN-γ) in response to both types of antigen, indicative of a Th1 response; however, after 72 h of incubation, only the native MSG stimulated secretion of IL-4 (Th2 response) from the cells. We then investigated whether the presence of IL-4 could alter the predominant Th1 phenotype by the CD4 cells in response to MSG and MSG-B. Cells cultured with native MSG and IL-4 produced low levels of IFN-γ and elevated levels of IL-4. Interestingly, cells incubated with MSG-B and IL-4 reduced production of IFN-γ, but were not stimulated to produce increased levels of IL-4. The presence of anti-IFN-γ antibody in the MSG- or MSG-B-stimulated cultures did not effect the expression of IFN-γ mRNA, suggesting that the generation of Th1 cells in response to MSG or MSG-B was not dependent on IFN-γ. We conclude that native MSG, which contains multiple forms of this antigen, and recombinant MSG elicit different cytokine responses in vitro. These data are not only important to studies of MSG, but may also be relevant to the role of MSG in the immunopathogenesis of P.carinii infection in vivo. 相似文献
9.
The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry 总被引:8,自引:1,他引:8
Nistico L; Buzzetti R; Pritchard LE; Van der Auwera B; Giovannini C; Bosi E; Larrad MT; Rios MS; Chow CC; Cockram CS; Jacobs K; Mijovic C; Bain SC; Barnett AH; Vandewalle CL; Schuit F; Gorus FK; Tosi R; Pozzilli P; Todd JA 《Human molecular genetics》1996,5(7):1075-1080
Susceptibility to autoimmune insulin-dependent (type 1) diabetes mellitus
is determined by a combination of environmental and genetic factors, which
include variation in MHC genes on chromosome 6p21 (IDDM1) and the insulin
gene on chromosome 11p15 (IDDM2). However, linkage to IDDM1 and IDDM2
cannot explain the clustering of type 1 diabetes in families, and a role
for other genes is inferred. In the present report we describe linkage and
association of type 1 diabetes to the CTLA-4 gene (cytotoxic T lymphocyte
associated-4) on chromosome 2q33 (designated IDDM12). CTLA-4 is a strong
candidate gene for T cell- mediated autoimmune disease because it encodes a
T cell receptor that mediates T cell apoptosis and is a vital negative
regulator of T cell activation. In addition, we provide supporting evidence
that CTLA-4 is associated with susceptibility to Graves' disease, another
organ- specific autoimmune disease.
相似文献
10.