全文获取类型
收费全文 | 444篇 |
免费 | 8篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 66篇 |
妇产科学 | 7篇 |
基础医学 | 30篇 |
口腔科学 | 47篇 |
临床医学 | 22篇 |
内科学 | 93篇 |
皮肤病学 | 17篇 |
神经病学 | 13篇 |
特种医学 | 2篇 |
外科学 | 50篇 |
综合类 | 26篇 |
预防医学 | 50篇 |
眼科学 | 1篇 |
药学 | 18篇 |
肿瘤学 | 9篇 |
出版年
2021年 | 8篇 |
2017年 | 3篇 |
2015年 | 43篇 |
2014年 | 22篇 |
2013年 | 11篇 |
2012年 | 9篇 |
2011年 | 3篇 |
2010年 | 13篇 |
2009年 | 11篇 |
2007年 | 4篇 |
2006年 | 7篇 |
2004年 | 2篇 |
2002年 | 2篇 |
2001年 | 3篇 |
1999年 | 2篇 |
1998年 | 7篇 |
1997年 | 8篇 |
1996年 | 11篇 |
1995年 | 8篇 |
1994年 | 5篇 |
1993年 | 4篇 |
1992年 | 8篇 |
1991年 | 4篇 |
1990年 | 4篇 |
1989年 | 10篇 |
1988年 | 4篇 |
1987年 | 5篇 |
1986年 | 4篇 |
1985年 | 6篇 |
1984年 | 4篇 |
1983年 | 4篇 |
1980年 | 3篇 |
1979年 | 4篇 |
1978年 | 4篇 |
1977年 | 2篇 |
1972年 | 3篇 |
1968年 | 2篇 |
1964年 | 2篇 |
1963年 | 2篇 |
1959年 | 20篇 |
1958年 | 21篇 |
1957年 | 28篇 |
1956年 | 20篇 |
1955年 | 24篇 |
1954年 | 40篇 |
1953年 | 2篇 |
1952年 | 1篇 |
1949年 | 9篇 |
1948年 | 13篇 |
1947年 | 4篇 |
排序方式: 共有452条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
ANA JP MORAES POLLYANA MF SOARES AURA L ZAPATA ANA PN LOTITO ADRIANA ME SALLUM CLOVIS AA SILVA 《Pediatrics international》2006,48(1):48-53
Background: The purpose of the present paper was to describe the clinical manifestations and treatment of patients with panniculitis. Methods: From January 1983 to December 2002, 4294 patients were treated for pediatric rheumatological diseases at Pediatric Rheumatology Unit, University of São Paulo, Brazil. Of these, 35 children and adolescents (0.8%) presented with panniculitis: erythema nodosum (EN) or Weber–Christian disease (WCD). Clinical characteristics, laboratory exams, biopsy of the lesion, treatment and clinical course were studied. Results: Of the 35 patients, 29 presented with EN and six with WCD, one of these with cytophagic histiocytic panniculitis. Mean age at symptom onset was 85 months (6–204 months) and the mean duration of follow up was 55 months (1–144 months). All the patients presented with inflammatory subcutaneous nodules. The patients with WCD presented with systemic manifestations and cutaneous atrophy. The principal etiologies of EN were streptococcal infection (42%), undetermined (13.5%), pulmonary tuberculosis (10%), and acute rheumatic fever (10%). Biopsy of the nodules indicated septal panniculitis in 14 patients with EN and lobular panniculitis without vasculitis in the patients with WCD, one of which had cytophagic histiocytic panniculitis. There was recurrence in 11 patients (38%) with EN and in all those with WCD. Non‐steroidal anti‐inflammatory drugs were used in 15 patients with EN and corticosteroids and/or immunosuppressive drugs in the six patients with WCD. Three patients died. Conclusions: EN is the most frequent panniculitis, with a benign course and is mainly associated with infections. WCD is a severe disease, with systemic involvement, that proceeds with cutaneous atrophy and requires the use of corticosteroids and or immunosuppressive drugs. 相似文献
6.
Isolated Regional Enteritis of the Duodenum 总被引:1,自引:0,他引:1
JOAO R. SILVA M.D. JOHN M. THOMAS M.D. F.A.C.S. † 《The American journal of gastroenterology》1972,57(4):349-352
7.
8.
Marisa de Carvalho BORGES Guilherme Azevedo TERRA Tharsus Dias TAKEUTI Betania Maria RIBEIRO Alex Augusto SILVA Júverson Alves TERRA-JúNIOR Virmondes RODRIGUES-JúNIOR Eduardo CREMA 《Brazilian archives of digestive surgery》2015,28(4):266-269
Background :
Immunological and inflammatory mechanisms play a key role in the development and progression of type 2 diabetes mellitus.Aim :
To raise the hypothesis that alterations in immunological parameters occur after duodenojejunal bypass surgery combined with ileal interposition without gastrectomy, and influences the insulin metabolism of betacells.Methods :
Seventeen patients with type 2 diabetes mellitus under clinical management were submitted to surgery and blood samples were collected before and six months after surgery for evaluation of the serum profile of proinflammatory (IFN-γ, TNF-α, IL-17A) and anti-inflammatory cytokines (IL-4, IL-10). In addition, anthropometric measures, glucose levels and insulin use were evaluated in each patient.Results :
No changes in the expression pattern of proinflammatory cytokines were observed before and after surgery. In contrast, there was a significant decrease in IL-10 expression, which coincided with a reduction in the daily insulin dose, glycemic index, and BMI of the patients. Early presentation of food to the ileum may have induced the production of incretins such as GLP-1 and PYY which, together with glycemic control, contributed to weight loss, diabetes remission and the consequent good surgical prognosis of these patients. In addition, the control of metabolic syndrome was responsible for the reduction of IL-10 expression in these patients.Conclusion :
These findings suggest the presence of low-grade inflammation in these patients during the postoperative period, certainly as a result of adequate glycemic control and absence of obesity, contributing to a good outcome of surgery. 相似文献9.
Paola Turchiello da SILVA Luciana Dapieve PATIAS Glauco da Costa ALVAREZ Vanessa Ramos KIRSTEN Elisangela COLPO Cristina Machado Bragan?a de MORAES 《Brazilian archives of digestive surgery》2015,28(4):270-273
Background :
Nowadays obesity is a chronic disease considered one of the greatest problems in public healthy. Showing to be effective in a short and long term, the bariatric surgery has emerged as an optional treatment for morbid obesity.Aim:
Identify the profile of patients seeking bariatric surgery.Methods:
Were interviewed 100 patients in preoperative nutritional monitoring of bariatric surgery. The study was conducted by applying a questionnaire prepared according to the research objectives.Results:
From the individuals that were seeking bariatric surgery, 78% were female, 62% were married and 69% reported physical activity. The average age of those surveyed was 37±10.83 years and mean body mass index (BMI) was 43.51± 6.25 kg/m². The comorbidity more prevalent in this group was high blood pressure (51%). In previous treatments for weight reduction, 92% have already done hypocaloric diet followed by anorectic drug (83%). The success of these treatments was reported by 92% of patients; however, the weight lost was recovered in less than one year of 75%. Patients with diabetes mellitus and dyslipidemia had higher BMI values. The patients with comorbidities showed lower levels of BMI.Conclusion:
The profile of patients who sought surgical treatment for their obesity were predominantly women with a family background of obesity and obesity-related comorbidities, especially hypertension and diabetes mellitus. 相似文献10.
Gustavo Henrique Rodriguez da SILVA Carla Beatriz Grespan BOTTOLI Francisco Carlos GROPPO Maria Cristina VOLPATO José RANALI Juliana Cama RAMACCIATO Rogério Heládio Lopes MOTTA 《Journal of applied oral science : revista FOB》2012,20(4):444-448