全文获取类型
收费全文 | 1642篇 |
免费 | 88篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 62篇 |
妇产科学 | 31篇 |
基础医学 | 117篇 |
口腔科学 | 8篇 |
临床医学 | 81篇 |
内科学 | 362篇 |
皮肤病学 | 89篇 |
神经病学 | 155篇 |
特种医学 | 77篇 |
外国民族医学 | 1篇 |
外科学 | 288篇 |
综合类 | 9篇 |
预防医学 | 81篇 |
眼科学 | 10篇 |
药学 | 78篇 |
中国医学 | 3篇 |
肿瘤学 | 276篇 |
出版年
2023年 | 8篇 |
2022年 | 10篇 |
2021年 | 38篇 |
2020年 | 16篇 |
2019年 | 35篇 |
2018年 | 28篇 |
2017年 | 26篇 |
2016年 | 29篇 |
2015年 | 39篇 |
2014年 | 43篇 |
2013年 | 64篇 |
2012年 | 94篇 |
2011年 | 105篇 |
2010年 | 61篇 |
2009年 | 70篇 |
2008年 | 68篇 |
2007年 | 65篇 |
2006年 | 66篇 |
2005年 | 58篇 |
2004年 | 54篇 |
2003年 | 61篇 |
2002年 | 60篇 |
2001年 | 43篇 |
2000年 | 49篇 |
1999年 | 41篇 |
1998年 | 26篇 |
1997年 | 23篇 |
1996年 | 32篇 |
1995年 | 17篇 |
1994年 | 26篇 |
1993年 | 18篇 |
1992年 | 31篇 |
1991年 | 39篇 |
1990年 | 33篇 |
1989年 | 37篇 |
1988年 | 30篇 |
1987年 | 18篇 |
1986年 | 21篇 |
1985年 | 20篇 |
1984年 | 15篇 |
1983年 | 7篇 |
1981年 | 7篇 |
1979年 | 12篇 |
1976年 | 9篇 |
1975年 | 11篇 |
1974年 | 9篇 |
1973年 | 6篇 |
1969年 | 9篇 |
1968年 | 9篇 |
1967年 | 7篇 |
排序方式: 共有1734条查询结果,搜索用时 31 毫秒
1.
R Rosso F Boccardo F Brema M R Sertoli D Amoroso G Bertelli P Pronzato 《Anticancer research》1989,9(4):1153-1156
131 patients with resectable, node-positive breast cancer were treated at the National Institute for Cancer Research of Genoa, Italy with a systemic adjuvant regimen based on 14 cycles of chemotherapy, immunostimulation with levamisole, and--for postmenopausal patients--hormone therapy with tamoxifen. The present evaluation is performed eleven years after the admission of the first patient: so far, 75 patients (57.3%) have relapsed and 52 (39.7%) have died. An analysis of prognostic factors for relapse and death shows that the number of positive axillary lymph nodes and the dimension of the primary tumor are significantly associated with survival and relapse-free survival, while age and menopausal status are not. 相似文献
2.
3.
The effect of a two day fast on maternal plasma volume and plasma protein concentration was explored in pregnant rats. Fasting between days 17 and 19 of gestation prevented the rise in plasma volume observed in ad libitum fed rats. Plasma protein concentration declined between day 17 and day 19 in both fasted and not fasted rats. Placental weight was not reduced by fasting during this stage of gestation. Fetal weight in the fasted group was 91% of the fetal weight of the ad libitum fed group. These results show that acute undernutrition, like longer term food or protein restriction, can prevent adequate plasma volume expansion and slow fetal growth. 相似文献
4.
5.
G Nanni MD G Balduzzi MD R Capoluongo MD A Scotti MD G Rosso MD C Botta MD P Demichelis MD M Daffara MD E Coppo MD 《Obesity surgery》1997,7(1):26-29
Background: Biliopancreatic diversion (BPD), by ad hoc stomach resection (AHS-BPD) has been accepted as an effective surgical treatment for morbid obesity. Methods: Between 1.1.1992
and 31.7.1996, 59 patients (54 females, five males, mean age 40.3 years, range 23-61 years) underwent AHS-BPD. Mean preoperative
body-weight was 121.2 kg (range 94-160), with a mean body mass index of 48.6 (range 35-64). Three of these patients were converted
from a previous vertical banded gastroplasty to AHS-BPD (one patient with stomach preservation). After at least 36 months
follow-up, seven patients underwent abdominal dermolipectomy (five with associated incisional hernia repair, one with thigh
dermolipectomy). Results: Mean post-operative hospital stay was 13 days (range 10-30 days). Follow-up is currently in progress
in all patients. Excess body weight-loss was 78% in 33 patients with 24 months follow-up, with excellent long-term weight
loss maintenance. Protein deficiency was the main specific complication, encountered in two patients (3.4%). Mortality was
one patient (1.7%), due to pulmonary embolus. Conclusions: This clinical experience supports the effectiveness and safety
of AHS-BPD, despite some criticism. This procedure appears to be suitable for patients with clinically severe obesity who
will poorly tolerate food intake restriction but will accept long-term follow-up. Careful preoperative clinical assessment
and selection of patients who will be reliable in long-term follow-up are the keys to success with AHS-BPD, both in terms
of weight loss and reduction of specific metabolic complications. 相似文献
6.
P Pronzato G Bertelli D Amoroso C Pennucci G Gardin T Guido P Rosso 《Chemotherapy》1991,37(6):449-453
An oral chemotherapy schedule based on idarubicin and cyclophosphamide was evaluated in 31 advanced breast cancer patients. Out of 27 patients evaluable for response, 1 (3.7%) achieved a complete response and 5 (18.5%) a partial response, with an objective response rate of 22.2% (95% confidence limits 8.6-42.3%). The median time to progression was 7 months (range 3-12). Fourteen patients (51.9%) showed a disease stabilization, and 7 progressed (25.9%). Toxicity was mild. Considering the low response rate, but also the advantages of oral chemotherapy and the mild toxicity observed, oral idarubicin plus cyclophosphamide can be considered as a second-choice regimen in advanced breast cancer. 相似文献
7.
8.
LEE JS IM HH JUNG Y JUNG IS JANG JY CHUN YK CHO YD KIM JO CHO JY KIM YS SHIM CS & KIM BS 《Neurogastroenterology and motility》2006,18(6):493-494
Background: Recent development of extracorporeal magnetic stimulation (ECMS) which uses current‐changing magnetic fields allows the induction of electrical stimulation in the desired deep tissue. Recent study showed the sacral nerve stimulation reduces corticoanal excitability that may play a functional role in anal continence mechanisms. Preliminary study shows that ECMS of sacral nerve can modify pelvic floor function and expel rectal balloon in patients with pelvic floor dyssynergia (PFD). Aims: To evaluate the effect of ECMS compared with biofeedback therapy (BF) in patients with PFD. Methods and Materials: Thirty‐eight patients who fulfilled Rome II criteria for PFD by colon transit time and anorectal function tests, were randomly treated with 8 sessions of ECMS (2/weeks; n = 19) at prone position or BF (2/weeks; n = 19) at sitting position. Stimulation parameters were set at 50–80% of maximum intensity, 10 and 50 Hz frequency, 3 s burst length with 3 and 6 s off using arm‐typed stimulator (BioCom‐1000, Mcube Co., Korea). Symptom scores for constipation with/without anorectal function test were repeatedly measured after each treatment. Response was defined as 50% or more decreased symptom score after treatment (partial response: 30–50%, poor: <30%). Results: Fifteen patients (age 49.1 ± 13.4 years, mean ± SD; 4 men) completed 8 session of BF and 14 patients (54.5 ± 17.6 years, 3 men) completed 8 session of ECMS. Four patients of BF group discontinued treatment due to unsatisfactory therapeutic effect (n = 1) and withdrew consent (n = 3) and 5 patients of ECMS group discontinued treatment because of same reasons (n = 1, 4). Total symptom scores were significantly decreased after treatment of 8 session in both treatment groups (13.4 ± 6.6 vs. 4.3 ± 4.0 for BF, p = 0.009; 14.9 ± 5.6 vs. 3.4 ± 4.0 for ECMS, p < 0.001). Bowel movements per week were also significantly increased after treatment in both groups (median 2 vs. 7 for BF, p = 0.035; median 2 vs. 7 for ECMS, p = 0.008). Thirteen out of 15 patients showed response in BF group and 12 out of 14 showed good response in ECMS group. No adverse effects in both groups. Conclusions: ECMS is as effective as BF for the treatment of PFD. Long‐term effect of ECMS for the patients with pelvic floor dyssynergia need to be evaluated in the near future. 相似文献
9.
E Campora C Naso M T Vitullo S Giudici A Camoirano L Repetto R Rosso 《Journal of chemotherapy (Florence, Italy)》1992,4(1):59-63
One hundred and thirty-seven breast cancer patients, 102 receiving adjuvant chemotherapy and 35 receiving palliative chemotherapy for metastatic disease underwent a 37-item quality-of-life questionnaire to evaluate the impact of disease and treatment on physical, psychological and social well being. Patient groups were designated as follows--Adj CT: patients undergoing the questionnaire during their adjuvant chemotherapy program; Post Adj CT: patients evaluated 3 to 8 months after termination of adjuvant chemotherapy; Mts CT: patients assessed during palliative chemotherapy for metastatic disease, and Post Mts CT: patients 3 to 8 months after termination of palliative chemotherapy. Physical and social activities were reported as unaltered or normal by 64 to 70% and 52 to 67% of patients, respectively. Psychological status was judged normal by 39 to 45% of patients. No significant differences were observed between the patients groups. In 83 to 90% of cases the patient normally took care of herself. In 62 to 87% of cases time dedicated to recreational activities was reported as unaltered. The majority of patients (84%) judged that their relationship with partner and/or family were good. Severe anxiety was reported in 19 to 28% of patients and severe depression was infrequent (3.9%). Information regarding disease and treatment given by health professionals was considered satisfactory by 80 to 100% of patients.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献