全文获取类型
收费全文 | 1094篇 |
免费 | 85篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 40篇 |
妇产科学 | 23篇 |
基础医学 | 187篇 |
口腔科学 | 43篇 |
临床医学 | 112篇 |
内科学 | 281篇 |
皮肤病学 | 13篇 |
神经病学 | 48篇 |
特种医学 | 78篇 |
外科学 | 92篇 |
综合类 | 12篇 |
预防医学 | 33篇 |
眼科学 | 12篇 |
药学 | 76篇 |
1篇 | |
中国医学 | 3篇 |
肿瘤学 | 123篇 |
出版年
2022年 | 6篇 |
2021年 | 22篇 |
2020年 | 6篇 |
2019年 | 13篇 |
2018年 | 18篇 |
2017年 | 15篇 |
2016年 | 15篇 |
2015年 | 31篇 |
2014年 | 31篇 |
2013年 | 49篇 |
2012年 | 47篇 |
2011年 | 46篇 |
2010年 | 48篇 |
2009年 | 35篇 |
2008年 | 41篇 |
2007年 | 35篇 |
2006年 | 41篇 |
2005年 | 49篇 |
2004年 | 43篇 |
2003年 | 32篇 |
2002年 | 32篇 |
2001年 | 32篇 |
2000年 | 32篇 |
1999年 | 29篇 |
1998年 | 28篇 |
1997年 | 25篇 |
1996年 | 37篇 |
1995年 | 28篇 |
1994年 | 26篇 |
1993年 | 19篇 |
1992年 | 23篇 |
1991年 | 19篇 |
1990年 | 10篇 |
1989年 | 16篇 |
1988年 | 16篇 |
1987年 | 11篇 |
1986年 | 13篇 |
1985年 | 17篇 |
1984年 | 11篇 |
1983年 | 17篇 |
1982年 | 10篇 |
1980年 | 8篇 |
1979年 | 7篇 |
1977年 | 10篇 |
1976年 | 7篇 |
1975年 | 7篇 |
1971年 | 7篇 |
1970年 | 9篇 |
1966年 | 9篇 |
1963年 | 5篇 |
排序方式: 共有1180条查询结果,搜索用时 15 毫秒
1.
2.
P E Santos E Piontelli Y R Shea M L Galluzzo S M Holland M E Zelazko S D Rosenzweig 《Medical mycology》2006,44(8):749-753
Infections due to Penicillium species other than P.marneffei are rare. We identified a boy with X-linked chronic granulomatous disease (X-CGD) with a pulmonary nodule and adjacent rib osteomyelitis caused by Penicillium piceum. The only sign of infection was an elevated sedimentation rate. P. piceum was isolated by fine needle aspirate and from excised infected tissues. Surgical removal and one year of voriconazole treatment were very well tolerated and led to complete recovery. Microbiological, microscopic and molecular studies support the fungal diagnosis. P. piceum should be considered as a relevant pathogen in immunocompromised patients. 相似文献
3.
Michael Rosenzweig Martha Skinner Tatiana Prokaeva Roger Théberge Catherine Costello Brian M Drachman Lawreen H Connors 《Amyloid》2007,14(1):65-71
We report the identification of a new transthyretin (TTR) gene mutation and variant protein, Glu61Gly, in a 55-year-old man with progressive cardiomyopathy, mild peripheral neuropathy and bilateral carpal tunnel syndrome. A diagnosis of TTR-associated familial amyloidosis (ATTR) was considered after an endomyocardial biopsy revealed amyloid deposits in the heart of a patient who had no family history of amyloidosis and no evidence of a plasma cell dyscrasia. Serum screening for a TTR variant by isoelectric focusing (IEF) was positive and prompted further studies to identify the genetic abnormality and to characterize the amyloidogenic protein. Direct DNA sequence analysis of all four coding regions in the TTR gene demonstrated heterozygosity in exon 3. Near equal amounts of guanine (G) and adenine (A) were observed at the second base position of codon 61. The wild-type (GAG) and mutated (GGG) sequences found in codon 61 correspond to glutamic acid (Glu) and glycine (Gly) residues, amino acids which differ in mass by -72 Da. Mass spectrometric analyses of TTR immunoprecipitated from serum showed the presence of both wild-type and variant proteins. The observed mass results for the wild-type and variant proteins were consistent with the predicted values calculated from the genetic analysis data. 相似文献
4.
C. S. Peretti J. M. Danion F. Kauffmann-Muller D. Grangé A. Patat P. Rosenzweig 《Psychopharmacology》1997,129(4):329-338
Buprenorphine is a mu opioid partial agonist currently used as an analgesic, and being developed for the treatment of opioid
dependence. The purpose of this study was to determine the abuse liability of parenteral buprenorphine in volunteers maintained
on daily sublingual (SL) buprenorphine (8 mg). In a residential laboratory, eight volunteers underwent pharmacologic challenges
two times per week. Medication challenges were 16 h after the daily dose of buprenorphine, and consisted of double-blind IM
injections of buprenorphine (4, 8, 16 mg), the prototypic mu opioid agonist hydromorphone (9 and 18 mg), or saline. Assessments
consisted of physiologic monitoring, subjects’ self-reports, and a trained observer’s ratings of drug effects, and were collected
for 0.5 h before and 2.0 h following injection. Supplemental doses of IM buprenorphine produced opioid agonist-like effects,
indicating some abuse potential of parenteral buprenorphine in buprenorphine-maintained patients. There was incomplete cross-tolerance
to the effects of hydromorphone, suggesting that higher maintenance doses of buprenorphine may be needed to maximize clinical
efficacy. However, there was a lack of graded dose-effects for hydromorphone, suggesting that buprenorphine’s combination
of partial agonist effects and high affinity for opioid receptors may limit the magnitude of effects of supplemental full
agonists. Finally, participants tolerated cumulative doses of maintenance buprenorphine plus challenge buprenorphine without
adverse effects, suggesting higher doses of buprenorphine can be safely administered to opioid dependent patients.
Received: 22 February 1996/Final version: 23 August 1996 相似文献
5.
6.
Golli M; Van Nhieu JT; Mathieu D; Zafrani ES; Cherqui D; Dhumeaux D; Vasile N; Rahmouni A 《Radiology》1994,190(3):741
7.
8.
9.
10.