Author Keywords: chronic depression; clinical trial; dysthymia; medication treatment; serotonergic antidepressants 相似文献
全文获取类型
收费全文 | 7069篇 |
免费 | 510篇 |
国内免费 | 14篇 |
专业分类
耳鼻咽喉 | 83篇 |
儿科学 | 400篇 |
妇产科学 | 129篇 |
基础医学 | 767篇 |
口腔科学 | 93篇 |
临床医学 | 702篇 |
内科学 | 1660篇 |
皮肤病学 | 201篇 |
神经病学 | 504篇 |
特种医学 | 505篇 |
外科学 | 1031篇 |
综合类 | 114篇 |
一般理论 | 3篇 |
预防医学 | 505篇 |
眼科学 | 154篇 |
药学 | 289篇 |
1篇 | |
中国医学 | 2篇 |
肿瘤学 | 450篇 |
出版年
2021年 | 85篇 |
2020年 | 71篇 |
2019年 | 76篇 |
2018年 | 101篇 |
2017年 | 73篇 |
2016年 | 92篇 |
2015年 | 121篇 |
2014年 | 116篇 |
2013年 | 181篇 |
2012年 | 254篇 |
2011年 | 224篇 |
2010年 | 162篇 |
2009年 | 184篇 |
2008年 | 249篇 |
2007年 | 272篇 |
2006年 | 264篇 |
2005年 | 247篇 |
2004年 | 245篇 |
2003年 | 216篇 |
2002年 | 187篇 |
2001年 | 196篇 |
2000年 | 191篇 |
1999年 | 178篇 |
1998年 | 153篇 |
1997年 | 140篇 |
1996年 | 136篇 |
1995年 | 100篇 |
1994年 | 90篇 |
1993年 | 84篇 |
1992年 | 170篇 |
1991年 | 153篇 |
1990年 | 141篇 |
1989年 | 179篇 |
1988年 | 178篇 |
1987年 | 178篇 |
1986年 | 164篇 |
1985年 | 189篇 |
1984年 | 118篇 |
1983年 | 118篇 |
1982年 | 61篇 |
1981年 | 62篇 |
1980年 | 57篇 |
1979年 | 107篇 |
1978年 | 72篇 |
1977年 | 74篇 |
1975年 | 63篇 |
1974年 | 56篇 |
1973年 | 71篇 |
1972年 | 61篇 |
1971年 | 49篇 |
排序方式: 共有7593条查询结果,搜索用时 0 毫秒
1.
2.
PJ Commerford 《Cardiovascular journal of Africa》2015,26(4):151-Aug;26(4):151
3.
4.
K A Rosenthal 《Dimensions of critical care nursing》1989,8(5):310-316
The information in this article is for a wide variety of nurses who find themselves in a teaching role: the critical care nurse orienting another nurse (experienced or new graduate); the critical care manager who needs to present an inservice program; and the educator or clinical specialist looking for a new way to present the same information. The author describes how self-paced modules for inservice education offer variety to learners since learners choose the teaching strategy that best suits their learning styles. 相似文献
5.
Steven J Lobritto Philip Rosenthal Rene Bouw Mimi Leung Paul Snell Richard D Mamelok 《Liver transplantation》2007,13(11):1570-1575
There are few pharmacokinetic data for mycophenolate mofetil (MMF) when used in combination with cyclosporine (CsA) in pediatric liver transplant recipients. The aim of this study was to assess the pharmacokinetics of MMF in stable pediatric liver transplant patients and estimate the dose of MMF required to provide a mycophenolic acid (MPA) exposure similar to that observed in adult liver transplant recipients receiving the recommended dose of MMF (target area under the plasma concentration-time curve from 0 to 12 hours [AUC(0-12)] for MPA of 29 mug.hour/mL in the immediate posttransplantation period and 58 microg x hour/mL after 6 months). A 12-hour pharmacokinetic profile was collected for 8 pediatric patients (mean age 20.9 months) on stable doses of MMF and CsA who had received a liver transplant > or = 6 months prior to entry and who had started on MMF within 2 weeks of transplantation. Mean MMF dosage was 285 mg/m(2) (range, 200-424 mg/m(2)). Of 8 patients, 7 had a MPA AUC(0-12) (range, 11.0-37.2 microg x hour/mL) well below the target. One patient had an AUC(0-12) > or = 58 microg x hour/mL but was considered an outlier and was excluded from analyses. Mean MPA AUC(0-12) and maximum plasma concentration values were 22.7 +/- 10.5 microg x hour/mL and 7.23 +/- 3.27 microg/mL, respectively; values normalized to 600 mg/m(2) (the approved pediatric dose in renal transplantation) were 47.0 +/- 21.8 microg x hour/mL and 14.5 +/- 4.21 microg/mL. In conclusion, assuming that MPA exhibits linear pharmacokinetics, when used in combination with CsA, a MMF dose of 740 mg/m(2) twice daily would be recommended in pediatric liver transplant recipients to achieve MPA exposures similar to those observed in adult liver transplant recipients. This finding should be confirmed by a prospective trial. 相似文献
6.
Mark A Rosenthal 《Journal of clinical neuroscience》2004,11(1):66-67
This case report describes the rare phenomenon of encephalopathy associated with massive carcinoid tumor. Extensive investigation failed to reveal an obvious cause but a presumptive diagnosis of tryptophan deficiency was made and she was commenced on tryptophan dietary supplements. A rapid and complete response resulted. This case report discusses this unusual case and reviews the literature regarding carcinoid associated encephalopathy. 相似文献
7.
Jennifer S. Singer Robert B. Ettenger John L. Gore H. Albin Gritsch Jacob Rajfer J. Thomas Rosenthal Peter Schulam 《American journal of transplantation》2005,5(10):2514-2520
Despite reports demonstrating the safety of laparoscopic donor nephrectomy (LDN) for pediatric recipients of renal transplants, recent evidence has challenged using LDN for recipients 5 years of age or younger. We retrospectively reviewed the records of all pediatric recipients of living donor renal transplants from September 2000 through August 2004. We compared those who received allografts recovered by LDN (n = 34) with those recovered by open donor nephrectomy (ODN, n = 26). Outcomes of interest included operative complications, postoperative renal function, the incidence of delayed graft function or episodes of acute rejection and long-term graft function. Donor and recipient demographic data were similar for the LDN and ODN groups. Serum creatinine and calculated creatinine clearance were not significantly different between groups both in the early postoperative period and at long-term follow-up (p > 0.142). Rates of delayed graft function and acute rejection did not differ between groups. Among recipients aged 5 years old or younger stratified by donor technique (9 LDN, 5 ODN recipients), no difference was noted in graft outcomes both early and long-term (p > 0.079). At our center, pediatric LDN recipients have graft outcomes comparable to those of ODN recipients. At experienced centers, we recommend continued use of LDN for pediatric recipients of all ages. 相似文献
8.
Charles A Lascano Samuel Szomstein Natan Zundel Raul J Rosenthal 《Surgery for obesity and related diseases》2005,1(4):443-446
The association between weight and blood pressure is well established, especially the paradigm of obesity-related hypertension. The relationship between diffuse autonomic dysfunction and orthostatic hypotension in patients with long-term diabetes mellitus is also well known. We report on a 57-year-old morbidly obese male with a long medical history of hypertension, myocardial infarction, type 2 diabetes mellitus, and hypothyroidism. After a loss of 147 pounds (representing a percent excess weight loss of 76%) within 6 months after gastric bypass surgery, the patient developed worsening orthostatic hypotension and near-syncopal episodes requiring medication. The subsequent diagnosis and treatment, as well as a literature review, are presented. 相似文献
9.
The effect of hypoprolactinemia alone and in combination with cyclosporine on allograft rejection 总被引:2,自引:0,他引:2
Recent evidence suggests that prolactin has a role in regulating immune function. Hypophysectomy or administration of bromocriptine results in suppression of the immune response, which is reversed by the administration of prolactin. Hypoprolactinemia has been shown to augment the immunosuppressive effect of cyclosporine. We studied the effect of hypoprolactinemia induced by a new drug, CQP 201-403, on the survival of heterotopic cardiac allografts in the rat and the ability of peripheral blood lymphocytes to respond in vitro to plant mitogens. CQP treatment alone produced a small increase in graft survival but no change in lymphocyte in vitro proliferation (P less than 0.05). CQP treatment greatly enhanced the immunosuppressive effect of cyclosporine on graft rejection and in vitro lymphocyte function (P less than 0.02). We conclude that modulation of prolactin may be a useful adjunct to cyclosporine immunosuppression. 相似文献
10.
Jesse Rosenthal Camille Hemlock David J. Hellerstein Phillip Yanowitch Karen Kasch Cynthia Schupak Lisa Samstag Arnold Winston 《Progress in neuro-psychopharmacology & biological psychiatry》1992,16(6):933-941
Rosenthal, Jesse et al. A Preliminary Study of Serotonergic Antidepressants in the Treatment of Dysthymia. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1992, 16(6): 933–941.
1. 1. There is increasing evidence that antidepressants may alleviate symptoms of dysthymia, but few prior studies on selective serotonergic agents.
2. 2. Twenty patients meeting criteria for dysthymia, but not meeting criteria for major depression, received open label trials of a serotonergic antidepressant, either fluoxetine or trazodone.
3. 3. Seventeen (85%) completed three-month medication trials, and of these, twelve (70.6% of completers) responded to treatment. Seven (41.2% of completers) were still in remission on followup at five months.
4. 4. Both fluoxetine and trazodone were well tolerated in dysthymics, and showed similar short-term effectiveness in treating dysthymic symptoms.