全文获取类型
收费全文 | 1745篇 |
免费 | 152篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 139篇 |
妇产科学 | 43篇 |
基础医学 | 243篇 |
口腔科学 | 63篇 |
临床医学 | 178篇 |
内科学 | 312篇 |
皮肤病学 | 20篇 |
神经病学 | 164篇 |
特种医学 | 33篇 |
外科学 | 129篇 |
综合类 | 23篇 |
一般理论 | 2篇 |
预防医学 | 280篇 |
眼科学 | 24篇 |
药学 | 86篇 |
中国医学 | 2篇 |
肿瘤学 | 138篇 |
出版年
2023年 | 8篇 |
2022年 | 20篇 |
2021年 | 32篇 |
2020年 | 23篇 |
2019年 | 36篇 |
2018年 | 35篇 |
2017年 | 41篇 |
2016年 | 42篇 |
2015年 | 42篇 |
2014年 | 51篇 |
2013年 | 61篇 |
2012年 | 127篇 |
2011年 | 132篇 |
2010年 | 59篇 |
2009年 | 59篇 |
2008年 | 111篇 |
2007年 | 109篇 |
2006年 | 113篇 |
2005年 | 108篇 |
2004年 | 106篇 |
2003年 | 93篇 |
2002年 | 104篇 |
2001年 | 37篇 |
2000年 | 34篇 |
1999年 | 22篇 |
1998年 | 28篇 |
1997年 | 21篇 |
1996年 | 11篇 |
1995年 | 19篇 |
1994年 | 14篇 |
1993年 | 17篇 |
1992年 | 18篇 |
1991年 | 17篇 |
1990年 | 12篇 |
1989年 | 9篇 |
1988年 | 6篇 |
1987年 | 8篇 |
1986年 | 7篇 |
1985年 | 6篇 |
1984年 | 9篇 |
1983年 | 11篇 |
1982年 | 15篇 |
1981年 | 9篇 |
1979年 | 4篇 |
1978年 | 4篇 |
1977年 | 9篇 |
1976年 | 5篇 |
1974年 | 3篇 |
1973年 | 7篇 |
1972年 | 3篇 |
排序方式: 共有1898条查询结果,搜索用时 31 毫秒
1.
We have previously reported the time trends, design and interventions in randomised controlled trials (RCTs) in cystic fibrosis (CF) from 1961 through 1997 [Cheng K, Smyth RL, Motley J, O'Hea U, Ashby D, Randomised controlled trials in cystic fibrosis (1966-1997) categorized by time, design, and intervention. Pediatr Pulmonol 2000, 29:1-7.]. We maintain an ongoing register of all RCTs and controlled clinical trials (CCTs) in CF and have noted that in the five years since 1997 there has been a 48% increase in published trials. We aimed to assess whether this increase has been associated with an improvement in design quality. All RCTs and CCTs from 1961-2002 were assessed. Two epochs were then compared, 1961-1997 and 1998-2002. For each trial we recorded the design, participant numbers and the intervention studied. 261 trials in 1998-2002 were compared with 544 trials in 1961-1997. Comparing the two epochs a similar proportion of trials were parallel, double-blind and placebo controlled; also the median number of participants was similar. In the later epoch 25% of trials were multicentre, compared with 11% previously. Whilst this recent increase in clinical trials in CF is welcome, this has not been associated with improvements in quality. The trend for an increasing proportion of trials to be multicentre is encouraging. There are however, still deficiencies in the design of clinical trials in CF. 相似文献
2.
3.
The complex enterprise of modelling prenatal exposure to cigarettes: what is ‘enough’? 总被引:1,自引:0,他引:1
Kate E. Pickett Paul J. Rathouz Vanja Dukic Kristen Kasza Marina Niessner Rosalind J. Wright Lauren S. Wakschlag 《Paediatric and perinatal epidemiology》2009,23(2):160-170
While there is a burgeoning body of research linking smoking during pregnancy to problem behaviour in offspring, a major criticism of this work has been the crude measurement of exposure in these studies (e.g. retrospective, self-reported only) that could lead to biased estimates. To address this issue, we used a pregnancy cohort with repeated prospective measures of exposure as well as biological assays to generate estimates of exposure patterns using a range of modelling techniques. In this paper we report on the analytical approaches we have developed, including patterns of exposure over time and best-estimate approaches that combine self-report and cotinine measures, and compare their predictive value in relation to different dimensions of fetal growth as a first step towards examining the utility of greater precision of exposure measurement.
Surprisingly, in this sample the more complex assessments of exposure, including biological measures, generally did not perform better than simple indicators of exposure based on repeated self-report measures, with one exception: a combined self-report cotinine 'best estimate' of third trimester exposure was uniquely associated with lower brain : body ratio. Further study is needed using more sophisticated cotinine assays and testing prediction of a range of outcomes to ascertain whether these findings represent true differences or are specific to the sample, methods and outcomes used. Such research will inform the development of guidelines for adequate exposure characterisation in developmental studies. 相似文献
Surprisingly, in this sample the more complex assessments of exposure, including biological measures, generally did not perform better than simple indicators of exposure based on repeated self-report measures, with one exception: a combined self-report cotinine 'best estimate' of third trimester exposure was uniquely associated with lower brain : body ratio. Further study is needed using more sophisticated cotinine assays and testing prediction of a range of outcomes to ascertain whether these findings represent true differences or are specific to the sample, methods and outcomes used. Such research will inform the development of guidelines for adequate exposure characterisation in developmental studies. 相似文献
4.
In our recent review of action control deficits in hemispatial neglect we concluded that many patients with the disorder have deficits in visuomotor control [Coulthard, E., Parton, A., & Husain, M. (2006). Action control in visual neglect. Neuropsychologia, 44(13), 2717-2733]. This conclusion has been questioned and it has been argued instead that there are no action deficits in neglect [Himmelbach, M., Karnath, H.-O., & Perenin, M.-T. (2007). Action control is not affected by spatial neglect: A comment on Coulthard et al. Neuropsychologia, 45(8), 1979-1981]. We proposed that rather than being specific to the neglect syndrome, action control deficits are more likely to relate to lesion location. Although many of these impairments may contribute to the manifestation of neglect, they may also occur in brain-damaged patients without the condition. In this article, we explore this framework further, discussing how neglect behaviour may emerge from damage to a set of visuomotor or cognitive modules, or their connections. Central to our view is the idea that the critical combination of deficits leading to neglect varies considerably between cases, and that visuomotor or cognitive modules disrupted in the syndrome may not, in fact, be specific to neglect. 相似文献
5.
6.
Clare Bradley Rosalind Plowright John Stewart John Valentine Elke Witthaus 《Health and quality of life outcomes》2007,5(1):57
Background
The results of using status measures to identify any changes in treatment satisfaction strongly suggest a need for specific change instruments designed to overcome the ceiling effects frequently observed at baseline. Status measures may leave little room to show improvement in situations where baseline ceiling effects are observed. A change version of the DTSQ (DTSQc) is compared here with the original status (now called DTSQs) version to test the instruments' comparative ability to demonstrate change. 相似文献7.
8.
K R Clark J L Forsythe K M Rigg J Sharp L Rangecroft J Wagget N R Parrott T W Lennard M G Coulthard 《Journal of pediatric surgery》1992,27(6):780-783
Since 1982 eight patients under 1 year of age with end-stage renal failure have been treated by chronic peritoneal dialysis (CPD) following insertion of an abdominal Tenckhoff catheter. We routinely perform a partial omentectomy now, and in males undertake bilateral exploration of the groins at the time of catheter insertion, with herniotomy or ligation of the patent processus vaginalis as required. Up to January 1990, 19 straight double-cuff catheters had been inserted with a total follow-up of 244.5 patient months. The median age at the initial catheter insertion was 14.6 weeks (range, 2 days to 11 months) and the median weight was 3.89 kg (range, 2.2 to 5.5). Peritonitis was the most common complication, with 46 episodes, representing one episode of peritonitis per 5.3 patient months on dialysis. The frequency of peritonitis has decreased in the last 6 months since all patients have been dialysed by two caregivers. The present rate of peritonitis is 1 episode per 10 patient months on dialysis. One patient has died of septicemia secondary to associated congenital abnormalities, one patient has regained renal function, and two patients have been transplanted, one successfully. Five patients are currently dialysing via their abdominal Tenckhoff catheters and awaiting transplantation. We conclude that neonates and infants under 1 year of age can be treated satisfactorily by CPD to enable successful preparation for transplantation later in childhood. 相似文献
9.
10.