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R Rondinelli J Murphy A Esler T Marciano C Cholmakjian 《American journal of physical medicine & rehabilitation / Association of Academic Physiatrists》1992,71(4):219-224
The purpose of this study was to determine the magnitude and clinical significance of surface measurement error in the determination of lumbar spinal flexion. Intrarater, inter-rater and intermethod reliability estimates were obtained using single inclinometry, double inclinometry and back range-of-motion inclinometry methods. Eight healthy subjects were examined independently by two experienced observers and three replicates of each measurement were obtained by each observer in a random sequence. In addition, three replicates of lumbar flexion angles were obtained for each subject by a single observer using the B-200. Reliability estimates were determined by intraclass correlation coefficients and were further compared by paired t tests between observation series. The median range of error was 8.5 degrees using the single inclinometer, 10.5 degrees using the double inclinometer and 16 degrees using the back range-of-motion. The intrarater reliability was generally higher than inter-rater reliability and intermethod reliability was low in most cases reflecting the poor cross-validity across inclinometry methods and between each inclinometry method and the B-200. In conclusion, significant measurement error in estimating lumbar flexion by inclinometry may be expected to occur even in a "controlled" setting using experienced observers, standard examination techniques and asymptomatic healthy subjects. These findings appear to undermine the expectation that the clinician can reliably apply surface inclinometry to estimate loss of spinal mobility for purposes of impairment determination. 相似文献
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Pituitary adenomas: relationship between invasiveness and proliferative cell nuclear index 总被引:3,自引:0,他引:3
We evaluated clinically, radiologically and surgically a series of 76 pituitary adenomas. All cases were assessed immunohistochemically and in 49 patients the PCNA monoclonal antibody was measured. The most frequent types found were the bihormonal adenomas, followed by prolactinomas and non secreting adenomas. The bihormonal adenomas, non secreting adenonas and the sub unit alfa producing adenomas were proportionally more invase as determined by radiological criteria (CTscan or MRI). In 59 patients a transphenoidal approach was used, six cases were operated on transcranially and in 11 patients we used a combination of both approach. Total resection were achieved in 32 cases, most of which were microadenomas, in 15 cases the resection was subtotal and partial in 29 cases. Diabetes insipidus was the most frequent endocrine complication. It was observed that secreting adenomas tend to be associated with an increased PCNA and invasive adenomas correlated with PCNA 3 and 4. An improvement in vision was observed in 85% of macroadenomas seen after a total, subtotal or partial resection. 相似文献
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Andrea Piccin Ciaran Murphy Elva Eakins Maria Beatrice Rondinelli Massimo Daves Cinzia Vecchiato Dominik Wolf Corrina Mc Mahon Owen P. Smith 《European journal of haematology》2019,102(4):319-330
Sickle cell anaemia (SCA) is the consequence of abnormal haemoglobin production due to an inherited point mutation in the β‐globin gene. The resulting haemoglobin tetramer is poorly soluble when deoxygenated, and when this is prolonged, intracellular gelation of sickle haemoglobin occurs, followed by haemoglobin polymerisation. If many cycles of sickling and unsickling occur, the red cell membrane will be disrupted leading to haemolysis and vaso‐occlusive events. Recent studies have also shown that leucocyte adhesion molecules and nitric oxide (NO) depletion are involved in endothelial damage. New insights in SCA pathophysiology and vascular biology have shown that cell‐derived microparticle (MP) generation is also involved in the vaso‐occlusion. Endothelial damage is perpetuated by impaired production or increased consumption of protective modulators such as protein C, protein S and NO. New therapeutic interventions should address these aspects of SCA pathogenesis. To date, the only US‐FDA‐approved therapy to prevent painful vaso‐occulsive episodes is hydroxyurea that reduces haemoglobin polymerisation in sickle cells by increasing the production of foetal haemoglobin and L‐glutamine. However, several new drugs have been tested in the last years in randomised clinical trials. We here report an update on the current status of knowledge on SCA. 相似文献
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Charles Watson Jan Provis Suzana Herculano‐Houzel 《Anatomical record (Hoboken, N.J. : 2007)》2012,295(10):1683-1691
How does the number of motor neurons in the brain correlate with the muscle mass to be controlled in the body? Numbers of motor neurons are known to be adjusted during development by cell death, but the change in the percentage of surviving motor neurons in response to experimental changes in target muscle mass is relatively small. Here we address the quantitative matching between final numbers of motor neurons in the facial nucleus and body mass (which we use as a proxy for the muscle mass). In 22 marsupial species, we found that the number of facial motor neurons is strongly correlated with body mass, and scales across species as a power function of body mass with a very small exponent of 0.184, which is close to the exponent found in primates from previously published data. With such an exponent, doubling the body mass is accompanied by a modest increase of only 14% in numbers of facial motor neurons, while halving body mass results in a decrease of only 12%. These numbers are remarkably similar to the 15–20% increase or 8% decrease in the number of spinal cord motor neurons that results from experimental or natural doubling or reducing by half the target muscle field of birds and amphibians. The scaling rule presented here might thus account for the quantitative matching of motor neurons to their target muscle mass in evolution. With this small scaling exponent, our data also raise the possibility that larger animals will have larger motor units. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc. 相似文献
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Silvio Rodrigues Marques-Neto Emanuelle Baptista Ferraz Deivid Carvalho Rodrigues Brian Njaine Edson Rondinelli Antônio Carlos Campos de Carvalho Jose Hamilton Matheus Nascimento 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》2014,28(2):125-135