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Hossein Abdolrahimzadeh Fard Salahaddin Mahmudi-Azer Qusay Abdulzahraa Yaqoob Golnar Sabetian Pooya Iranpour Zahra Shayan Shahram Bolandparvaz Hamid Reza Abbasi Shiva Aminnia Maryam Salimi Mohammad Mehdi Mahmoudi Shahram Paydar Roham Borazjani Ali Taheri Akerdi Masome Zare Leila Shayan Mohammadreza Sasani 《中华创伤杂志(英文版)》2022,25(3):170-176
ProposeIn this study, we re-assessed the criteria defined by the radiological society of North America (RSNA) to determine novel radiological findings helping the physicians differentiating COVID-19 from pulmonary contusion.MethodsAll trauma patients with blunt chest wall trauma and subsequent pulmonary contusion, COVID-19-related signs and symptoms before the trauma were enrolled in this retrospective study from February to May 2020. Included patients (Group P) were then classified into two groups based on polymerase chain reaction tests (Group Pa for positive patients and Pb for negative ones). Moreover, 44 patients from the pre-pandemic period (Group PP) were enrolled. They were matched to Group P regarding age, sex, and trauma-related scores. Two radiologists blindly reviewed the CT images of all enrolled patients according to criteria defined by the RSNA criteria. The radiological findings were compared between Group P and Group PP; statistically significant ones were re-evaluated between Group Pa and Group Pb thereafter. Finally, the sensitivity and specificity of each significant findings were calculated. The Chi-square test was used to compare the radiological findings between Group P and Group PP.ResultsIn the Group PP, 73.7% of all ground-glass opacities (GGOs) and 80% of all multiple bilateral GGOs were detected (p < 0.001 and p = 0.25, respectively). Single bilateral GGOs were only seen among the Group PP. The Chi-square tests showed that the prevalence of diffused GGOs, multiple unilateral GGOs, multiple consolidations, and multiple bilateral consolidations were significantly higher in the Group P (p = 0.001, 0.01, 0.003, and 0.003, respectively). However, GGOs with irregular borders and single consolidations were more significant among the Group PP (p = 0.01 and 0.003, respectively). Of note, reticular distortions and subpleural spares were exclusively detected in the Group PP.ConclusionWe concluded that the criteria set by RSNA for the diagnosis of COVID-19 are not appropriate in trauma patients. The clinical signs and symptoms are not always useful either. The presence of multiple unilateral GGOs, diffused GGOs, and multiple bilateral consolidations favor COVID-19 with 88%, 97.62%, and 77.7% diagnostic accuracy. 相似文献
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Anatomy of medial plantar superficial branch artery perforators: Facilitation of medial plantar superficial branch artery perforator (MPAP) flap harvesting and design for finger pulp reconstruction 下载免费PDF全文
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Hansmann G Plouffe BD Hatch A von Gise A Sallmon H Zamanian RT Murthy SK 《Journal of molecular medicine (Berlin, Germany)》2011,89(10):971-983
The number of circulating endothelial progenitor cells (EPCs) inversely correlates with cardiovascular risk and clinical outcome,
and thus has been proposed as a valuable biomarker for risk assessment, disease progression, and response to therapy. However,
current strategies for isolation of these rare cells are limited to complex, laborious approaches. The goal of this study
was the design and validation of a disposable microfluidic platform capable of selectively capturing and enumerating EPCs
directly from human whole blood in healthy and diseased subjects, eliminating sample preprocessing. We then applied the “EPC
capture chip” clinically and determined EPC numbers in blood from patients with pulmonary arterial hypertension (PAH). Blood
was collected in tubes and injected into polymeric microfluidic chips containing microcolumns pre-coated with anti-CD34 antibody.
Captured cells were immunofluorescently stained for the expression of stem and endothelial antigens, identified and counted.
The EPC capture chip was validated with conventional flow cytometry counts (r = 0.83). The inter- and intra-day reliability of the microfluidic devices was confirmed at different time points in triplicates
over 1–5 months. In a cohort of 43 patients with three forms of PAH (idiopathic/heritable, drug-induced, and connective tissue
disease), EPC numbers are ≈50% lower in PAH subjects vs. matched controls and inversely related to two potential disease modifiers:
body mass index and postmenopausal status. The EPC capture chip (5 × 30 × 0.05 mm3) requires only 200 μL of human blood and has the strong potential to serve as a rapid bedside test for the screening and
monitoring of patients with PAH and other proliferative cardiovascular, pulmonary, malignant, and neurodegenerative diseases. 相似文献
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Feasibility of Therapeutic Effects of the Cholinergic Anti-Inflammatory Pathway on COVID-19 Symptoms
Journal of Neuroimmune Pharmacology - 相似文献
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Roham Borazjani Javad Kojuri Alireza AbdiArdekani Peyman Izadpanah Pooyan Dehghani Mehrab Sayadi Armin Attar 《Journal of clinical hypertension (Greenwich, Conn.)》2020,22(9):1627
Currently, the best treatment strategy for patients with a high‐normal blood pressure (prehypertension) is not known. The authors aimed to determine whether pharmacological reduction of systolic blood pressure (SBP) to a normal level (<120 mm Hg) would prevent cardiac morbidity and mortality in prehypertensive patients. In this secondary analysis, the authors obtained the data from SPRINT from the National Heart, Lung, and Blood Institute data repository center. Among 9361 patients enrolled in SPRINT, 289 high‐risk (ASCVD risk = 24.8% ± 13.0 [10‐65]) prehypertensive patients without previous cardiovascular disease and not receiving any antihypertensive medications were enrolled. One hundred and forty‐eight of them were assigned to standard treatment which consisted of clinical follow‐up till SBP goes above 140 mm Hg and then staring medications to keep SBP <140 mm Hg. One hundred and forty‐one were assigned to the intensive treatment receiving pharmacological SBP reduction to <120 mm Hg upon enrollment. The primary composite outcome was myocardial infarction, and other acute coronary syndromes, stroke, heart failure, or death from cardiovascular causes. Throughout the 3.06 years of follow‐up, a primary outcome event was confirmed in three participants (0.74% per year) in the intensive‐treatment group and 8 (1.61% per year) in the standard‐treatment group (hazard ratio [HR], 0.19; P = .045). Rates of serious adverse events were not increased by intensive‐treatment (HR, 0.83; P = .506). Based on this secondary post hoc analysis, intensive SBP reduction may probably be beneficial for primary prevention of cardiovascular morbidity and mortality in high‐risk prehypertensive patients. This finding needs to be evaluated in a larger trial designed specifically to answer this question. 相似文献
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Ventetuolo CE Benza RL Peacock AJ Zamanian RT Badesch DB Kawut SM 《Proceedings of the American Thoracic Society》2008,5(5):617-622
Pulmonary arterial hypertension is a rare and often devastating disease, although various effective therapies are now available. Clinical trials have used hemodynamic, cardiac imaging, laboratory, and exercise measurements as surrogate and intermediate end points in pulmonary arterial hypertension. Yet, based on the current literature, it is difficult to surmise which of these (if any) have been definitively validated. In addition, investigators have advocated the use of combined clinical end points in future clinical trials. The dependence of clinical trials and clinical management on such end points warrants a review of their use. 相似文献
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Roham Soheilian Mohammad Hossein Jabbarpour Bonyadi Hamidreza Moein Mojgan Babanejad Alireza Ramezani Mehdi Yaseri Masoud Soheilian 《International ophthalmology》2017,37(5):1161-1168