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de França Juliane Santos de Sales-Neto José Marreiro Carvalho Deyse Cristina Madruga de Almeida Lima Éssia Olegário Tayná Rodrigues Mendes Rhuan Karlos Santos Lima-Junior Claudio Gabriel de Almeida Vasconcellos Mário Luiz Araújo Rodrigues-Mascarenhas Sandra 《Inflammation》2021,44(3):899-907
Inflammation - Morita-Baylis-Hillman adducts (MBHA) are synthetic molecules with several biological actions already described in the literature. It has been previously described that adduct... 相似文献
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José Guilherme F. M. Galvão Luiz Henrique Agra Cavalcante-Silva Deyse Cristina M. Carvalho Laércia Karla D. P. Ferreira Talissa Mozzini Monteiro Adriano Francisco Alves Larissa Adiles M. P. Ferreira Francisco Allysson A. F. Gadelha Marcia Regina Piuvezam Sandra Rodrigues-Mascarenhas 《Inflammation research》2018,67(3):277-277
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P. L. Jacob J. A. Leite A. K. A. Alves Y. K. S. Rodrigues F. M. Amorim P. L. N. Néris M. R. Oliveira S. Rodrigues-Mascarenhas 《Parasitology research》2013,112(3):1313-1321
Ouabain is a cardiotonic steroid identified as an endogenous substance of human plasma, being produced by the adrenal, pituitary, and hypothalamus. Despite the studies demonstrating the ability of ouabain to modulate inflammation and other aspects of the immune response, the effects of this substance in Leishmaniasis is unknown. The purpose of this work was to understand the immunomodulatory activity of ouabain in experimental Leishmaniasis in Swiss mice. It was demonstrated that ouabain reduced total cell numbers in the peritoneal cavity as a reflex of the inhibition of neutrophil migration induced by Leishmania (L.) Amazonensis. Furthermore, ouabain reduced TNF-α and IFN-γ levels, without cytotoxicity against peritoneal macrophages. These data showed the anti-inflammatory role of ouabain in the early events of the immune response triggered by Leishmania (L.) Amazonensis infection in murine model. 相似文献
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José Guilherme F. M. Galvão Luiz Henrique Agra Cavalcante-Silva Deyse Cristina M. Carvalho Laércia Karla D. P. Ferreira Talissa Mozzini Monteiro Adriano Francisco Alves Larissa Adilis M. P. Ferreira Francisco Allysson A. F. Gadelha Marcia Regina Piuvezam Sandra Rodrigues-Mascarenhas 《Inflammation research》2017,66(12):1117-1130
Purpose
Ouabain, an Na+/K+-ATPase inhibitor hormone, presents immunomodulatory actions, including anti-inflammatory effect on acute inflammation models.Methods
In the present study, the effect of ouabain in a model of allergic airway inflammation induced by ovalbumin (OVA) was assessed.Results
Initially, it was observed that ouabain treatment inhibited cellular migration induced by OVA on bronchoalveolar lavage fluid (BALF), mostly granulocytes, without modulating macrophage migration. In addition, it was observed, by flow cytometry, that ouabain reduces CD3high lymphocytes cells on BALF. Furthermore, treatment with ouabain decreased IL-4 and IL-13 levels on BALF. Ouabain also promoted pulmonary histological alterations, including decreased cell migration into peribronchiolar and perivascular areas, and reduced mucus production in bronchioles regions observed through hematoxylin–eosin (HE) and by periodic acid-Schiff stain, respectively. Allergic airway inflammation is characterized by high OVA-specific IgE serum titer. This parameter was also reduced by the treatment with ouabain.Conclusions
Therefore, our data demonstrate that ouabain negatively modulates allergic airway inflammation induced by OVA.
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