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1.
Mathur SK Singh S Marwah N Jindal R Arora B Rattan KN 《Indian journal of pathology & microbiology》2004,47(2):261-263
Pancreatoblastoma or infantile pancreatic carcinoma is a rare pancreatic tumor with distinct acinar and squamoid cell differentiation that generally affects infants and young children. Ultrasound and CT scan may be useful but preoperative diagnosis is often quite difficult. The outcome is generally favourable. A such case of 10 years old boy with an abdominal mass is being presented. 相似文献
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Junxi Liu Rebecca C. Richmond Jack Bowden Ciarrah Barry Hassan S. Dashti Iyas Daghlas Jacqueline M. Lane Samuel E. Jones Andrew R. Wood Timothy M. Frayling Alison K. Wright Matthew J. Carr Simon G. Anderson Richard A. Emsley David W. Ray Michael N. Weedon Richa Saxena Deborah A. Lawlor Martin K. Rutter 《Diabetes care》2022,45(4):772
OBJECTIVETo examine the effects of sleep traits on glycated hemoglobin (HbA1c).RESEARCH DESIGN AND METHODSThis study triangulated evidence across multivariable regression (MVR) and one- (1SMR) and two-sample Mendelian randomization (2SMR) including sensitivity analyses on the effects of five self-reported sleep traits (i.e., insomnia symptoms [difficulty initiating or maintaining sleep], sleep duration, daytime sleepiness, napping, and chronotype) on HbA1c (in SD units) in adults of European ancestry from the UK Biobank (for MVR and 1SMR analyses) (n = 336,999; mean [SD] age 57 [8] years; 54% female) and in the genome-wide association studies from the Meta-Analyses of Glucose and Insulin-Related Traits Consortium (MAGIC) (for 2SMR analysis) (n = 46,368; 53 [11] years; 52% female).RESULTSAcross MVR, 1SMR, 2SMR, and their sensitivity analyses, we found a higher frequency of insomnia symptoms (usually vs. sometimes or rarely/never) was associated with higher HbA1c (MVR 0.05 SD units [95% CI 0.04–0.06]; 1SMR 0.52 [0.42–0.63]; 2SMR 0.24 [0.11–0.36]). Associations remained, but point estimates were somewhat attenuated after excluding participants with diabetes. For other sleep traits, there was less consistency across methods, with some but not all providing evidence of an effect.CONCLUSIONSOur results suggest that frequent insomnia symptoms cause higher HbA1c levels and, by implication, that insomnia has a causal role in type 2 diabetes. These findings could have important implications for developing and evaluating strategies that improve sleep habits to reduce hyperglycemia and prevent diabetes. 相似文献
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Malik Nassan Iyas Daghlas John W. Winkelman Hassan S. Dashti International Suicide Genetics Consortium Richa Saxena 《Neuropsychopharmacology》2022,47(9):1672
Insomnia and restless leg syndrome (RLS) are associated with increased risk for suicidal behavior (SB), which is often comorbid with mood or thought disorders; however, it is unclear whether these relationships are causal. We performed a two-sample Mendelian randomization study using summary-level genetic associations with insomnia symptoms and RLS against the outcomes of risk of major depressive disorder (MDD), bipolar disorder (BP), schizophrenia (SCZ), and SB. The inverse-variance weighted method was used in the main analysis. We performed replication and sensitivity analyses to examine the robustness of the results. We identified outcome cohorts for MDD (n = 170,756 cases/329,443 controls), BP (n = 20,352/31,358), SCZ (n = 69,369/236,642), SB-Cohort-2019 (n = 6569/14,996 all with MDD, BP or SCZ; and SB within individual disease categories), and SB-Cohort-2020 (n = 29,782/519,961). Genetically proxied liability to insomnia symptoms significantly associated with increased risk of MDD (odds ratio (OR) = 1.23, 95% confidence interval (CI) = 1.2–1.26, P = 1.37 × 10–61), BP (OR = 1.15, 95% CI = 1.07–1.23, P = 5.11 × 10–5), SB-Cohort-2019 (OR = 1.17, 95% CI = 1.07–1.27, P = 2.30 × 10–4), SB-Cohort-2019 in depressed patients (OR = 1.34, 95% CI = 1.16–1.54, P = 5.97 × 10–5), and SB-Cohort-2020 (OR = 1.24, 95% CI = 1.18–1.3, P = 1.47 × 10–18). Genetically proxied liability to RLS did not significantly influence the risk of any of the outcomes (all corrected P > 0.05). Results were replicated for insomnia with MDD and SB in Mass General Brigham Biobank and were consistent in multiple lines of sensitivity analyses. In conclusion, human genetic evidence supports for the first time a potentially independent and causal effect of insomnia on SB and encourages further clinical investigation of treatment of insomnia for prevention or treatment of SB.Subject terms: Genetic markers, Risk factors, Psychiatric disorders 相似文献
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Mohit K Joshi Richa Joshi Manish Chadha Shan E Alam Hemant Varshneya Sunil Kumar 《Indian Journal of Palliative Care》2013,19(2):113-115
Skeletal metastasis as a primary presentation of gall bladder carcinoma is rare. A 50-year-old lady presented with neck pain and weakness in her right upper limb of 3 months duration. Clinical and imaging work-up suggested locally advanced gall bladder carcinoma with metastasis to cervical vertebra and sternum. Only one case till date has been reported where the patient presented with neurological symptoms due to pathological fracture secondary to metastasis from an occult gall bladder carcinoma. Although rare, an occult gall bladder cancer may present with neurological symptoms due to pathological fracture of spine secondary to metastasis. We present a brief review of literature of patients who presented with skeletal metastases in clinically silent gall bladder malignancy. Palliative care issues in advanced gall bladder carcinoma have also been discussed. 相似文献
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Richa Rai Madhoolika Agrawal 《Proceedings of the National Academy of Sciences, India. Section B.》2012,82(2):241-257
Tropospheric ozone (O3) is the most important regional atmospheric pollutant causing risk to food production across the globe due to its phytotoxicity and prevalence over agricultural areas. Peak O3 concentrations have declined in Europe and North America due to reductions in precursors during the last decades, however, emissions of O3 precursors have increased in Asia. The current critical level of ozone is determined by the threshold for yield loss which is based on the seasonal sum of the external concentration above 40?ppb. In the present article, the impact of tropospheric O3 on crop photosynthesis, defense mechanism, growth, reproductive processes and yield of crop plants have been documented. O3 upon its entry into the leaf intercellular spaces rapidly forms reactive oxygen species and reacts with components of the leaf apoplast to initiate a complex set of responses that constitute variable countermeasures by antioxidative enzymes. Ozone affects photosynthetic process by influencing photosynthetic pigments, chlorophyll fluorescence kinetics and electron transport as well as carbon fixation in terms of decreased Rubisco activity and quantity. Translocation and allocation pattern of photosynthate also get influenced under O3, which affect reproductive processes and yield of crops. Plant species and cultivars exhibit a range of sensitivity to O3, which is identifiable in terms of biochemical, physiological, molecular and yield responses. Hence, understanding of cultivar sensitivity in context to O3 would be helpful in development of potential O3 biomarkers and O3 tolerant variables. 相似文献
9.
Richa H Camerlo A Campanile M Hardwigsen J Le Treut YP 《Hepato-gastroenterology》2008,55(85):1365-1366
After radical resection of cancer of the right colonic flexure, a parietal defect can be created in case of duodenal invasion. In this paper the authors describe an "easy and safe" duodenoplasty surgical technique using an ileal patch. 相似文献
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