全文获取类型
收费全文 | 1750篇 |
免费 | 112篇 |
国内免费 | 32篇 |
专业分类
耳鼻咽喉 | 20篇 |
儿科学 | 74篇 |
妇产科学 | 45篇 |
基础医学 | 200篇 |
口腔科学 | 66篇 |
临床医学 | 184篇 |
内科学 | 446篇 |
皮肤病学 | 21篇 |
神经病学 | 60篇 |
特种医学 | 285篇 |
外国民族医学 | 2篇 |
外科学 | 184篇 |
综合类 | 31篇 |
预防医学 | 68篇 |
眼科学 | 53篇 |
药学 | 67篇 |
肿瘤学 | 88篇 |
出版年
2023年 | 12篇 |
2022年 | 29篇 |
2021年 | 50篇 |
2020年 | 27篇 |
2019年 | 36篇 |
2018年 | 72篇 |
2017年 | 33篇 |
2016年 | 19篇 |
2015年 | 32篇 |
2014年 | 65篇 |
2013年 | 56篇 |
2012年 | 80篇 |
2011年 | 77篇 |
2010年 | 68篇 |
2009年 | 54篇 |
2008年 | 49篇 |
2007年 | 71篇 |
2006年 | 70篇 |
2005年 | 41篇 |
2004年 | 48篇 |
2003年 | 52篇 |
2002年 | 26篇 |
2001年 | 22篇 |
2000年 | 19篇 |
1999年 | 28篇 |
1998年 | 66篇 |
1997年 | 80篇 |
1996年 | 87篇 |
1995年 | 51篇 |
1994年 | 44篇 |
1993年 | 45篇 |
1992年 | 22篇 |
1991年 | 18篇 |
1990年 | 23篇 |
1989年 | 46篇 |
1988年 | 47篇 |
1987年 | 35篇 |
1986年 | 35篇 |
1985年 | 36篇 |
1984年 | 13篇 |
1983年 | 16篇 |
1982年 | 15篇 |
1981年 | 12篇 |
1980年 | 12篇 |
1979年 | 3篇 |
1978年 | 5篇 |
1977年 | 15篇 |
1976年 | 11篇 |
1975年 | 7篇 |
1963年 | 5篇 |
排序方式: 共有1894条查询结果,搜索用时 15 毫秒
1.
Isolated patellofemoral arthritis is an increasingly recognized entity, and is usually associated with previous patellofemoral dysplasia or instability. Patellofemoral arthroplasty (PFA) has evolved significantly in recent years, both in terms of implant design and importantly in the understanding of appropriate patient selection. This review outlines the indications and investigations for PFA, provides a brief history of the development of contemporary implants, and presents the clinical outcomes for the prostheses most commonly used in the UK. In addition, it provides a detailed surgical technique for implantation of an onlay implant, with tips on how to optimize patellofemoral biomechanics and thus achieve a consistently good outcome. 相似文献
2.
3.
Sonoelasticity imaging of prostate cancer: in vitro results 总被引:2,自引:0,他引:2
4.
5.
6.
7.
Steven N Singh X Charlene Tang Bramah N Singh Paul Dorian Domenic J Reda Crystal L Harris Ross D Fletcher Satish C Sharma J Edwin Atwood Alan K Jacobson H Daniel Lewis Becky Lopez Dennis W Raisch Michael D Ezekowitz 《Journal of the American College of Cardiology》2006,48(4):721-730
OBJECTIVES: The purpose of this study was to determine quality of life (QOL) and exercise performance (EP) in patients with persistent atrial fibrillation (AF) converted to sinus rhythm (SR) compared with those remaining in or reverting to AF. BACKGROUND: Restoration of SR in patients with AF improving QOL and EP remains controversial. METHODS: Patients with persistent AF were randomized double-blind to amiodarone, sotalol, or placebo. Those not achieving SR at day 28 were cardioverted and classified into SR or AF groups at 8 weeks (n = 624) and 1 year (n = 556). The QOL (SF-36), symptom checklist (SCL), specific activity scale (SAS), AF severity scale (AFSS), and EP were assessed. RESULTS: Favorable changes were seen in SR patients at 8 weeks in physical functioning (p < 0.001), physical role limitations (p = 0.03), general health (p = 0.002), and vitality (p < 0.001), and at 1 year in general health (p = 0.007) and social functioning (p = 0.02). Changes in the scores for SCL severity (p = 0.01), functional capacity (p = 0.003), and AFSS symptom burden (p < 0.001) at 8 weeks and in SCL severity (p < 0.01) and AF symptom burden (p < 0.001) at 1 year showed significant improvements in SR versus AF. Symptomatic patients were more likely to have improvement. The EP in SR versus AF was greater from baseline to 8 weeks (p = 0.01) and to 1 year (p = 0.02). The EP correlated with physical functioning and functional capacity except in the AF group at 1 year. CONCLUSIONS: In patients with persistent AF, restoration and maintenance of SR was associated with improvements in QOL measures and EP. There was a strong correlation between QOL measures and EP. 相似文献
8.
9.
Ten thrombocytopenic patients (platelets < 10–24 × 10(9)/L) who were refractory to platelet transfusion were investigated for their responsiveness to staphylococcal protein A column therapy. Nine patients had previously been treated with steroids, intravenous immune globulin, and/or other forms of immunosuppressive therapy without improvement in their transfusion response. All patients were receiving multiple platelet transfusions without achieving 1-hour corrected count increments (CCIs) > or = 7500. Eight patients had antibodies that reacted with platelets and were directed against HLA class I antigens, ABO antigens, and/or platelet-specific alloantigens. Plasma (500-2000 mL) from each patient was passed over a protein A silica gel column and then returned to the patient. Patients received from 1 to 14 treatments. A positive response to protein A therapy was defined as at least a doubling of the pretreatment platelet count and/or two successive 10- to 120-minute posttransfusion CCIs > or = 7500. Following plasma treatments, 6 of 10 patients responded with daily platelet counts that averaged 48 +/− 11 × 10(9) per L as compared with counts of 16 +/− 7 × 10(9) per L (p < 0.0005) before treatment. Posttransfusion CCI values determined in four of these patients averaged 2480 +/− 810 and 10,010 +/− 3540 (p < 0.005) before and after treatment, respectively. In contrast, among the four unresponsive patients, platelet counts averaged 10 +/− 9 and 13 +/− 10 × 10(9) per L (p = NS), respectively, while posttransfusion CCIs were 700 +/− 1410 and 1520 +/− 2460 (p = NS), respectively.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
10.
目的 探索LDH实验检测细胞活力的可行性。方法 原代培养骨髓细胞和软骨细胞,用LDH实验测定上述两组细胞的活力,并与镜下活体观察到细胞的生长状况相比较。与目前比较成熟的测定细胞活力的MTS实验的测得的值相比较。结果 LDH实验对上述两组细胞的活力的测定结果与镜下活体观察到的结果相符合。与MTS实验的测得的结果经统计学处理无显著差异。结论 LDH实验可用于细胞活力的直接测定,而对活细胞的生存、繁殖无影响。 相似文献