全文获取类型
收费全文 | 1499篇 |
免费 | 92篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 66篇 |
妇产科学 | 29篇 |
基础医学 | 163篇 |
口腔科学 | 10篇 |
临床医学 | 163篇 |
内科学 | 378篇 |
皮肤病学 | 39篇 |
神经病学 | 174篇 |
特种医学 | 70篇 |
外科学 | 149篇 |
综合类 | 17篇 |
预防医学 | 162篇 |
眼科学 | 21篇 |
药学 | 75篇 |
1篇 | |
中国医学 | 8篇 |
肿瘤学 | 62篇 |
出版年
2022年 | 14篇 |
2021年 | 43篇 |
2020年 | 30篇 |
2019年 | 40篇 |
2018年 | 47篇 |
2017年 | 21篇 |
2016年 | 38篇 |
2015年 | 30篇 |
2014年 | 46篇 |
2013年 | 73篇 |
2012年 | 80篇 |
2011年 | 96篇 |
2010年 | 66篇 |
2009年 | 56篇 |
2008年 | 63篇 |
2007年 | 78篇 |
2006年 | 78篇 |
2005年 | 75篇 |
2004年 | 69篇 |
2003年 | 58篇 |
2002年 | 46篇 |
2001年 | 45篇 |
2000年 | 49篇 |
1999年 | 28篇 |
1998年 | 23篇 |
1997年 | 25篇 |
1996年 | 21篇 |
1995年 | 15篇 |
1994年 | 14篇 |
1993年 | 13篇 |
1992年 | 12篇 |
1991年 | 12篇 |
1990年 | 17篇 |
1989年 | 16篇 |
1988年 | 21篇 |
1987年 | 9篇 |
1986年 | 14篇 |
1985年 | 14篇 |
1984年 | 5篇 |
1983年 | 8篇 |
1982年 | 8篇 |
1981年 | 9篇 |
1979年 | 7篇 |
1978年 | 6篇 |
1977年 | 13篇 |
1976年 | 6篇 |
1970年 | 4篇 |
1967年 | 3篇 |
1966年 | 3篇 |
1965年 | 3篇 |
排序方式: 共有1594条查询结果,搜索用时 15 毫秒
1.
G M Fleischner R Morecki T Hanaichi H Hayashi N Quintana I Sternlieb 《Hepatology (Baltimore, Md.)》1991,14(3):422-425
A 56-yr-old woman with long-standing rheumatoid arthritis exhibited jaundice, pruritus and abdominal discomfort after 8 yr of periodic gold sodium thiomalate injections amounting to a cumulative dose in excess of 2.5 gm. Histopathological examination of the liver biopsy specimen showed submassive loss of parenchyma, collapse of reticulin and mixed cellular inflammatory infiltrates. Macrophages contained dark granules, which displayed the characteristics of aurosomes when examined by transmission electron microscopy and electron microprobe analysis. It is likely that hepatocellular injury occurred when the lysosomal storage capacity for gold was exceeded. 相似文献
2.
对30例稳定性心衰患者进行放射性核素心室造影和时相分析,确定基线时和最大耐受剂量卡维地洛治疗6个月后左心室和心室间的收缩同步性。与正常人群相比,心衰患者具有明显的心室不同步。基线时具有最显著不同步的患者中第50位百分位数表明,接受卡维地洛治疗后心室同步性得到显著改善,这与舒张末期左心室容量降低呈正相关。卡维地洛对慢性心衰患者心室内和心室间同步性的影响@Castro P. F.$Dr. Faculty of Medicine, P. Catholic University of Chile, University of Chile, Santiago, Chile
@Mc-Nab P.
@Quintana J. C.
@王… 相似文献
3.
José M Quintana Inmaculada Arostegui Antonio Escobar Iratxe Lafuente Juan C Arenaza Isidoro Garcia Urko Aguirre 《BMC musculoskeletal disorders》2007,8(1):84
Background
To develop a sensitive and specific screening tool for knee and hip osteoarthritis in the general population of elderly people. 相似文献4.
López-Giral S Quintana NE Cabrerizo M Alfonso-Pérez M Sala-Valdés M De Soria VG Fernández-Rañada JM Fernández-Ruiz E Muñoz C 《Journal of leukocyte biology》2004,76(2):462-471
B cell neoplasms present heterogeneous patterns of lymphoid organ involvement, which may be a result of the differential expression of chemokine receptors. We found that chemokine receptor (CCR)7, CXC chemokine receptor (CXCR)4, or CXCR5, the main chemokine receptors that mediate B cell entry into secondary lymphoid tissues and their homing to T cell and B cell zones therein, were highly expressed in B malignancies with widespread involvement of lymph nodes. Conversely, those pathologies with little or no nodular dissemination showed no expression to very low levels of CCR7 and CXCR5 and low to moderate levels of CXCR4. These findings provide evidence for the role of CCR7, CXCR4, and CXCR5 in determining the pattern of lymphoid organ involvement of B tumors. Functional studies were performed on B malignancies expressing different levels of CCR7, CXCR5, and CXCR4. Multiple myeloma (MM) cells did not express CCR7 nor CXCR5 and did not migrate in response to their ligands; a moderate expression of CXCR4 on MM cells was accompanied by a migratory response to its ligand, CXCL12. By contrast, cells from B cell chronic lymphocytic leukemia (B-CLL) expressed the highest levels of these chemokine receptors and efficiently migrated in response to all ligands of CCR7, CXCR4, and CXCR5. In addition, the migration index of B-CLL cells in response to both of the CCR7 ligands correlated with the presence of clinical lymphadenopathy, thus indicating that the high expression of functional chemokine receptors justifies the widespread character of B-CLL, representing a clinical target for the control of tumor cell dissemination. 相似文献
5.
Regulation of the antibody response to sheep erythrocytes by monoclonal IgG antibodies 总被引:1,自引:0,他引:1
Ilana Zalcberg Quintana Angela V. Silveira Güran Mller 《European journal of immunology》1987,17(9):1343-1349
Monoclonal antibodies directed against sheep erythrocytes of the isotypes IgG1, IgG2b and IgG2a were used to analyze the specificity of antibody-induced suppression of the immune response. It was first shown that all monoclonals reacted against different antigenic determinants and they all suppressed the immune response to sheep erythrocytes when given shortly after the antigen to more than 50% as compared to 90-96% inhibition obtained with a polyclonal antiserum. Increasing the doses of monoclonals did not increase suppression. However, two different monoclonals administered together caused an additive, but not a synergistic inhibitory effect. No enhancement of the immune response was observed with any of the Ig classes tested. These findings show that four different antigenic determinants on sheep erythrocytes induced the synthesis of corresponding antibodies, with little or no signs of a dominant determinant. Passively administered monoclonal antibodies, even at supraoptimal doses, never suppressed the immune response to the same extent as a polyclonal antiserum, suggesting that each monoclonal only suppressed the synthesis of the corresponding antibody and did not affect antibody synthesis to other determinants. 相似文献
6.
Bacon RM Gilmore RD Quintana M Piesman J Johnson BJ 《Journal of medical entomology》2003,40(4):590-592
Amblyomma americanum collected near Lake Wappapello, Missouri, tested positive for Borrelia lonestari using polymerase chain reaction and sequence analyses of B. lonestari 16S rRNA and flagellin (flaB) genes. Twelve pools containing a total of 214 nymph or adult ticks contained evidence of infection with B. lonestari (minimum prevalence 5.6%). These data suggest that persons in southeast Missouri are at risk for exposure to B. lonestari after A. americanum tick bite, a possible cause of erythema migrans-like rash illness in this region. Derivation of the complete coding sequence for B. lonestari flaB is also reported. 相似文献
7.
Naive non-obese diabetic (NOD/LtJ) mice spontaneously produce natural IgG autoantibodies against self-antigens associated with the experimental autoimmune diseases to which they are susceptible: insulin-dependant diabetes mellitus, systemic lupus erythematosus and experimental autoimmune encephalomyelitis. We discovered recently that NOD/LtJ mice also spontaneously produce IgG antibodies to the acetylcholine receptor (AchR), an antigen that can induce experimental autoimmune myasthenia gravis (EAMG) in susceptible rodents. However, there are no reports indicating that NOD/LtJ mice are susceptible to EAMG. To test whether the presence of spontaneous IgG autoantibodies can predict susceptibility to an autoimmune disease, we challenged NOD/LtJ mice using a standard protocol to induce EAMG. We now report that NOD/LtJ mice developed EAMG, although to a somewhat lesser degree than did C57BL/6 mice, a strain regarded as highly susceptible to the disease. Both strains produced comparable levels of immune antibodies to AchR of the complement-fixing isotypes IgG2a and IgG2b; however, NOD/LtJ mice produced significantly more IgG1. An antigen-specific T cell proliferative response to AchR of the same magnitude was detected in both strains, together with the secretion of similar amounts of IFN-gamma. Thus, NOD/LtJ mice are susceptible to EAMG and disease induction is accompanied by immune responses comparable to those seen in the susceptible strain C57BL/6. These results support the association between specific, natural IgG autoantibodies and susceptibility to the induction of a particular autoimmune disease. 相似文献
8.
The role of size, sequence and haplotype in the stability of FRAXA and FRAXE alleles during transmission 总被引:2,自引:5,他引:2
Murray A; Macpherson JN; Pound MC; Sharrock A; Youings SA; Dennis NR; McKechnie N; Linehan P; Morton NE; Jacobs PA 《Human molecular genetics》1997,6(2):173-184
Factors involved in the stability of trinucleotide repeats during
transmission were studied in 139 families in which a full mutation,
premutation or intermediate allele at either FRAXA or FRAXE was
segregating. The transmission of alleles at FRAXA, FRAXE and four
microsatellite loci were recorded for all individuals. Instability within
the minimal and common ranges (0-40 repeats for FRAXA, 0-30 repeats for
FRAXE) was extremely rare; only one example was observed, an increased in
size at FRAXA from 29 to 39 repeats. Four FRAXA and three FRAXE alleles in
the intermediate range (41-60) repeats for FRAXA, 31-60 for FRAXE) were
unstably transmitted. Instability was more frequent for FRAXA intermediate
alleles that had a tract of pure CGG greater than 37 although instability
only occurred in two of 13 such transmissions: the changes observed were
limited to only one or two repeats. Premutation FRAXA alleles over 100
repeats expanded to a full mutation during female transmission in 100% of
cases, in agreement with other published series. There was no clear
correlation between haplotype and probability of expansion of FRAXA
premutations. Instability at FRAXA or FRAXE was more often observed in
conjunction with a second instability at an independent locus suggesting
genomic instability as a possible mechanism by which at least some FRAXA
and FRAXE mutations arise.
相似文献
9.
Dr. J. Quintana 《Journal of neural transmission (Vienna, Austria : 1996)》1985,64(3-4):271-284
Summary Calcium has been shown to enter cholinergic synaptosomes transiently during potassium-induced depolarization, in which ACh and ATP are released together. Because junctional ATP is rapidly hydrolyzed by extracellular ATPases, I studied and compared the roles of ATP, ADP, AMP, and adenosine (Ade) on the control of calcium uptake during depolarization.Pure cholinergic synaptosomes of Torpedo fish electric organ were depolarized by high potassium concentrations and the amount of calcium uptake was then measured in the presence of equal concentrations of Ade and its related nucleotides. Calcium uptake was more inhibited when the nucleotide was less phosphorylated. Thus, Ade was the greatest inhibitor.Because Ade is quickly and actively taken up from the extracellular medium by synaptosomes and converted intracellularly to ATP, I also measured the capacity of Ade, after its initial inhibitory action, to reactivate the calcium uptake. After a short preincubation with Ade, the later uptake of calcium was enhanced. The combined results support a complete role of adenosine and related nucleotides in the control of calcium movement across the presynaptic membrane. 相似文献
10.