全文获取类型
收费全文 | 1058篇 |
免费 | 87篇 |
国内免费 | 26篇 |
专业分类
儿科学 | 28篇 |
妇产科学 | 25篇 |
基础医学 | 131篇 |
口腔科学 | 10篇 |
临床医学 | 117篇 |
内科学 | 177篇 |
皮肤病学 | 15篇 |
神经病学 | 77篇 |
特种医学 | 64篇 |
外科学 | 196篇 |
综合类 | 56篇 |
一般理论 | 1篇 |
预防医学 | 95篇 |
眼科学 | 37篇 |
药学 | 82篇 |
中国医学 | 3篇 |
肿瘤学 | 57篇 |
出版年
2022年 | 8篇 |
2021年 | 18篇 |
2020年 | 15篇 |
2019年 | 19篇 |
2018年 | 17篇 |
2017年 | 15篇 |
2016年 | 28篇 |
2015年 | 15篇 |
2014年 | 23篇 |
2013年 | 46篇 |
2012年 | 37篇 |
2011年 | 41篇 |
2010年 | 39篇 |
2009年 | 39篇 |
2008年 | 47篇 |
2007年 | 60篇 |
2006年 | 41篇 |
2005年 | 38篇 |
2004年 | 45篇 |
2003年 | 22篇 |
2002年 | 34篇 |
2001年 | 20篇 |
2000年 | 29篇 |
1999年 | 33篇 |
1998年 | 25篇 |
1997年 | 28篇 |
1996年 | 27篇 |
1995年 | 30篇 |
1994年 | 18篇 |
1993年 | 29篇 |
1992年 | 20篇 |
1991年 | 24篇 |
1990年 | 22篇 |
1989年 | 27篇 |
1988年 | 17篇 |
1987年 | 14篇 |
1986年 | 15篇 |
1985年 | 19篇 |
1984年 | 13篇 |
1983年 | 10篇 |
1982年 | 8篇 |
1981年 | 5篇 |
1980年 | 5篇 |
1979年 | 8篇 |
1978年 | 7篇 |
1977年 | 5篇 |
1976年 | 7篇 |
1973年 | 5篇 |
1971年 | 5篇 |
1969年 | 7篇 |
排序方式: 共有1171条查询结果,搜索用时 15 毫秒
1.
Joseph M. Northey Kate L. Pumpa Clare Quinlan Ashley Ikin Kellie Toohey Disa J. Smee Ben Rattray 《Journal of Science and Medicine in Sport》2019,22(5):580-585
Objectives
The current study investigated the effects of two exercise interventions on cognitive function amongst breast cancer survivors.Design
Pilot randomised-controlled trial.Methods
Seventeen female cancer survivors (mean: 62.9 ± 7.8 years) were randomised into three groups: high-intensity interval training (HIIT, n = 6); moderate-intensity continuous training (MOD, n = 5); or wait-list control (CON, n = 6). The HIIT and MOD groups exercised on a cycle ergometer 3 days/week for 12-weeks. Primary outcomes were cognitive function assessments utilising CogState. Secondary outcomes were resting middle cerebral artery blood flow velocity, cerebrovascular reactivity and aerobic fitness (VO2peak). Data were analysed with General Linear Mixed Models and Cohen’s d effect sizes were calculated.Results
All 17 participants who were randomised were available for follow-up analysis and adherence was similar for HIIT and MOD (78.7 ± 13.2% vs 79.4 ± 12.0%; p = 0.93). Although there were no significant differences in the cognitive and cerebrovascular outcomes, HIIT produced moderate to large positive effects in comparison to MOD and CON for outcomes including episodic memory, working memory, executive function, cerebral blood flow and cerebrovascular reactivity. HIIT significantly increased VO2peak by 19.3% (d = 1.28) and MOD had a non-significant 5.6% (d = 0.72) increase, compared to CON which had a 2.6% decrease.Conclusions
This study provides preliminary evidence that HIIT may be an effective exercise intervention to improve cognitive performance, cerebrovascular function and aerobic fitness in breast cancer survivors. Considering the sample size is small, these results should be confirmed through larger clinical trials. 相似文献2.
P C Walsh D M Quinlan R A Morton M S Steiner 《The Urologic clinics of North America》1990,17(3):679-684
The striated urethral sphincter is the predominant muscular structure divided posteriorly during the apical dissection in radical prostatectomy. The authors have long realized the value of this maneuver in obtaining excellent apical surgical margins and in identifying the correct plane on the anterior surface of the rectum. Recently, they also have recognized the importance of incorporating this musculature into the vesicourethral anastomosis to fix the bladder neck and thus re-establish anatomic continuity. Identification of the striated urethral sphincter ranks in importance with elucidation of the anatomy of the dorsal vein complex and the anatomic identification of the neurovascular bundle in improving the patient's quality of life postoperatively. 相似文献
3.
Creation of a circumferentially protruding urinary intestinal stoma is an important aspect to prevent stomal regression, stenosis and parastomal herniation. Furthermore, an improperly fashioned stoma may make fitting of an ostomy appliance difficult, resulting in urinary leakage with secondary dermatitis and incrustation. The major difficulty in fashioning the stoma is everting the mucosa over the intestinal mesentery. We describe our method of stoma formation that creates a circumferentially symmetrical protruding stoma free of tension that has been used successfully even in obese patients. This technique has made the use of a Turnbull stoma unnecessary in our recent experience. 相似文献
4.
5.
Asbestos causes translocation of p65 protein and increases NF-kappa B DNA binding activity in rat lung epithelial and pleural mesothelial cells.
下载免费PDF全文
![点击此处可从《The American journal of pathology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
6.
7.
Timothy J Beebe Stephen E Asche Patricia A Harrison Kathryn B Quinlan 《The Journal of adolescent health》2004,35(2):116-123
PURPOSE: To profile adolescent Internet chat room users in terms of demographic characteristics, psychological and environmental factors, and behavioral risk factors. METHODS: The study sample was drawn from respondents to an anonymous statewide survey of 50,168 9th-grade public school students and included 40,376 students who reported Internet access at home and 19,511 who accessed chat rooms. Data were collected by the Minnesota Student Survey (MSS), a survey that has been administered triennially by the state's education department to public school students in grades 6, 9, and 12 since 1989. The MSS includes more than 117 questions (300 variables) addressing attitudinal, behavioral, and environmental issues. Data analysis consisted of comparing the odds of a particular characteristic or behavior for chat room users with that of nonusers. Analyses were run separately for boys and girls. The homogeneity of odd ratios was tested with the Breslow-Day statistic using SPSS for Windows. RESULTS: For boys and girls, use of Internet chat rooms was associated with psychological distress, a difficult living environment, and a higher likelihood of risky behaviors. Although most chat room users did not report serious problems, this group included a disproportionate number of troubled individuals. CONCLUSIONS: Because chat room use serves as an indicator of heightened vulnerability and risk-taking, parents and others need to be aware of potential dangers posed by online contact between strangers and youth. 相似文献
8.
CA von Arnim R Spoelgen ID Peltan M Deng S Courchesne M Koker T Matsui H Kowa SF Lichtenthaler MC Irizarry BT Hyman 《The Journal of neuroscience》2006,26(39):9913-9922
The beta-amyloid (Abeta) precursor protein (APP) is cleaved sequentially by beta-site of APP-cleaving enzyme (BACE) and gamma-secretase to release the Abeta peptides that accumulate in plaques in Alzheimer's disease (AD). GGA1, a member of the Golgi-localized gamma-ear-containing ARF-binding (GGA) protein family, interacts with BACE and influences its subcellular distribution. We now report that overexpression of GGA1 in cells increased the APP C-terminal fragment resulting from beta-cleavage but surprisingly reduced Abeta. GGA1 confined APP to the Golgi, in which fluorescence resonance energy transfer analyses suggest that the proteins come into close proximity. GGA1 blunted only APP but not notch intracellular domain release. These results suggest that GGA1 prevented APP beta-cleavage products from becoming substrates for gamma-secretase. Direct binding of GGA1 to BACE was not required for these effects, but the integrity of the GAT (GGA1 and TOM) domain of GGA1 was. GGA1 may act as a specific spatial switch influencing APP trafficking and processing, so that APP-GGA1 interactions may have pathophysiological relevance in AD. 相似文献
9.
Mathy Mezey Eileen Quinlan Susan Fairchild Maria Vezina 《Journal for nurses in staff development》2006,22(1):2-10
Nurses in staff development are responsible for assuring nurses' competence in the delivery of care. Older patients are the predominant population in hospitals, yet there are no instruments that specifically assess the competency of nurses to deliver care to older patients. This article reports on the development and testing of an instrument, Geriatric Competencies for RNs in Hospitals, and makes recommendations as to how staff development educators can use the geriatric competency instrument with staff nurses. 相似文献
10.
应用放射配体结合法证实大鼠胸腺内存在降黑素特异结合部位,该结合位点可以满足特异结合部位的基本条件:1.低结合容量;2.高亲和力;3.可饱和性;4.可逆性;5.对降黑素高度特异性。此外,该特异结合位点具昼夜节律;亚细胞分布的研究表明以细胞核含量最高,线粒体次之,并具有年龄依赖性降低,以出生时最高。 相似文献