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排序方式: 共有207条查询结果,搜索用时 15 毫秒
1.
Mohamed Hebbar 《Current colorectal cancer reports》2005,1(1):34-40
New chemotherapy drugs and, more recently, targeted therapies have significantly improved the outcome of patients with resected
stage III colon cancer (adjuvant chemotherapy) and patients with unresectable metastases (palliative therapy). These advances
raise several questions about the place of chemotherapy after and before surgery in patients with resectable liver metastases.
To date, only a combined intra-arterial plus systemic fluoropyrimidine-based chemotherapy regimen has clearly demonstrated
a relapse-free survival benefit. Yet, this approach is restricted to specialized centers, mainly because of technical difficulties
and locoregional toxicities. The role of systemic use of oxaliplatin- and irinotecan-based regimens is currently under investigation.
Planned trials will assess the role of anti-angiogenic and anti-epidermal growth factor receptor agents. We review the main
trials performed in patients with resectable metastases, and discuss their potent impact on clinical practice. 相似文献
2.
William D. Stoll Robert A. Mester James N. Fleming Joel M. Sirianni Joseph A. Abro Edward D. Colhoun David J. Taber Latha Hebbar 《Transplantation proceedings》2021,53(5):1665-1669
BackgroundLiver transplantation is a complex surgical procedure. The experience of the anesthesiologist, and its potential relationship to patient morbidity and mortality, is yet to be determined. We sought to explore this possible association using our institutional training patterns as the subject of study.MethodsThis is a single center retrospective analysis investigating the association of an anesthesiologist's experience with liver transplantation and its potential effect on early patient outcomes in adult liver transplant recipients from January 2010 to September 2016. Training of team members consisted of a 6-month period of clinical shadowing with a senior anesthesiologist and co-staffing 8 liver transplant procedures before solo staffing a liver transplant. Specifically, patient outcomes for the first 5 transplants after this training were investigated.ResultsThe only independent risk factor for early death or early graft loss was the amount of packed red blood cells administered during transplantation. With respect to secondary outcomes, the amount of packed red blood cells and hospitalization at the time of transplant were associated with the number of days on a ventilator, length of intensive care unit stay, and overall hospital length of stay.ConclusionsThe results of this study conclude that the training model currently in place for our new team members has no negative impact on patient outcomes after liver transplantation. 相似文献
3.
Administration of caffeine (1,3,7-trimethylxanthine), a major component of coffee, to Swiss mice at doses of 80 or 100 mg/kg body weight 60 min prior to whole-body lethal dose of gamma-irradiation (7.5 Gy) resulted in the survival of 70 and 63% of animals, respectively, at the above doses in contrast to absolutely no survivors (LD-100/25 days) in the group exposed to radiation alone. Pre-treatment with a lower concentration of caffeine (50 mg/kg) did not confer any radioprotection. The protection exerted by caffeine (80 mg/kg), however, was reduced from 70 to 50% if administered 30 min prior to irradiation. The trend statistics reveal that a dose of 80 mg/kg administered 60 min before whole-body exposure to 7.5 Gy is optimal for maximal radioprotection. However, caffeine (80 mg/kg) administered within 3 min after irradiation offered no protection. While there is documentation in the literature that caffeine is an antioxidant and radioprotector against the oxic pathway of radiation damage in a wide range of cells and organisms, this is the first report demonstrating unequivocally its potent radioprotective action in terms of survival of lethally whole-body irradiated mice. 相似文献
4.
B. R. Prashantha Kumar S. Sopna Jenson Verghese Bijoy Desai M. J. Nanjan 《Medicinal chemistry research》2012,21(5):624-633
We report both automated rigid and flexible ligand docking simulations performed on fifty peroxisome proliferator-activated
receptor (PPAR-γ) agonists, namely, glitazones. The binding conformations and binding affinities of these agonists were obtained
by the use of the Autodock 4.1 with Lamarckian genetic algorithm (LGA). All the 50 flexible docks are considered as well-docked
as all of them were bound to the ligand binding domain of PPAR-γ. The predicted binding affinity values (pKa) were found to
have some degree of correlation with their experimental in vivo activity values. The head group hydrogen bond interactions
via H323 and H449 histidine residues were found to play a significant role. The results obtained will be valuable in designing
newer selective PPAR-γ agonists. 相似文献
5.
Kiran B Hebbar Toni Petrillo-Albarano Wendy Coto-Puckett Micheal Heard Peter T Rycus James D Fortenberry 《Critical care (London, England)》2009,13(2):R29-8
Introduction
Severe status asthmaticus (SA) in children may require intubation and mechanical ventilation with a subsequent increased risk of death. In the patient with SA and refractory hypercapnoeic respiratory failure, use of extracorporeal life support (ECLS) has been anecdotally reported for carbon dioxide removal and respiratory support. We aimed to review the experience of a single paediatric centre with the use of ECLS in children with severe refractory SA, and to compare this with international experience from the Extracorporeal Life Support Organization (ELSO) registry. 相似文献6.
Kyndt X Launay D Hebbar M Hatron PY Fournier C Michon-Pasturel U Hachulla E Devulder B 《La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne》1999,20(12):1088-1092
PURPOSE: The present study was aimed at assessing the influence of age on clinical and biological features of systemic sclerosis. METHODS: This retrospective study included 151 consecutive patients with systemic sclerosis. The median age at diagnosis was 50.0 years (range: 10-84 years). Patients were divided into two groups according to their age (lower than 50.0 years of age: 73 patients, equal to or above 50 years of age: 78 patients). The following features were compared between the two groups: gender, disease duration, extent of skin sclerosis, Crest syndrome, lung fibrosis, secondary Sj?gren's syndrome, antinuclear, anticentromere, and anti-Scl70 antibodies. RESULTS: The disease duration was significantly higher in patients over 50 years of age (7.1 +/- 6.8 years vs 5.5 +/- 5.0 years, P < 0.05). Crest syndrome, secondary Sj?gren's syndrome and anticentromere antibodies were significantly more common in patients over 50 years of age (17/73 vs 30/78, P < 10(-2); 9/73 vs 20/78, P < 10(-2), and 19/73 vs 31/78, P < 0.05; respectively). Anti-Scl70 antibodies were significantly more common in patients under 50 years of age (17/73 vs 10/78, P < 10(-2)). No significant difference was found in regard to the other features. CONCLUSION: The clinical and biological patterns of systemic sclerosis are different according to the age at disease onset. Crest syndrome including anticentromere antibodies and Sj?gren's syndrome is more common in elderly patients, while anti- Scl-70 antibodies are more common in younger patients. This suggests the involvement of various mechanisms in the pathogenesis of systemic sclerosis, and that these mechanisms may depend on the age. 相似文献
7.
Vinay Kumaran Naimish N. Mehta Vibha Varma Shashank Pandey Prashantha S. Rao Barun Nath Ashwin Mallya Naresh Bansal Samarjit Ghuman Sunita Bhalla Samiran Nundy 《Indian journal of gastroenterology》2012,31(4):179-185
Aim
We describe the first living donor intestinal transplant (LDIT) in India and discuss the indications and problems of this complex procedure.Methods
A 43-year-old male patient required massive bowel resection for gangrene due to thrombosis of the superior mesenteric artery. He was maintained on parenteral nutrition but developed cholestasis and well as repeated catheter related infections with progressive loss of venous access due to thrombosis of central veins. A LDIT was performed using 200?cm of small intestine from the patient's son. The graft was based on the continuation of the superior mesenteric vessels beyond the ileocolic branch. The artery was anastomosed directly to the aorta and the vein to the venacava.Results
The graft functioned well and he was weaned off parenteral nutrition. However, he later developed complications (wound dehiscence and enterocutaneous fistula) and developed sepsis. He succumbed to sepsis with a functioning graft 6?weeks after the transplant. The donor recovered uneventfully and was discharged on the 4th postoperative day.Conclusions
LDIT can be life saving in patients with intestinal failure and failure of parenteral nutrition. There is a need to introduce this modality in India. In a setting of scarcity of deceased donor organs the living donor option has advantages. 相似文献8.
Sharat Damodar Prashantha Bhat Praveen Kumar Rajesh TR Ratan Gupta 《Indian journal of hematology & blood transfusion》2014,30(1):64-67
Acute leukemia, secondary myelodysplasia and paroxysmal nocturnal hemoglobinuria evolving from severe aplastic anemia (AA) following immunosuppressive therapy are well recognized. However, severe AA occurring after complete remission of acute promyelocytic leukemia (APL) has been documented only once in 2009. We report a case of 30-year-old male diagnosed with APL who achieved complete cytogenetic remission with all-trans retinoic acid based induction regimen and developed severe AA few months later during maintenance therapy. 相似文献
9.
10.
Vikram Palimar Vinod C. Nayak M. Arun Pradeep G. Kumar Prashantha Bhagavath 《Journal of Forensic and Legal Medicine》2010,17(4):220-222
In a case of firearm fatality, the autopsy surgeon is required to opine as to the range of fire in addition to the cause of death which will help in reconstruction of the events. Problems may arise in estimating the range of fire based on wound ballistics when there is an alteration or modification in the internal ballistics. We encountered such a case in the department of Forensic Medicine, Kasturba Medical College, Manipal, which is discussed. 相似文献