全文获取类型
收费全文 | 278篇 |
免费 | 19篇 |
专业分类
儿科学 | 7篇 |
妇产科学 | 8篇 |
基础医学 | 39篇 |
口腔科学 | 1篇 |
临床医学 | 28篇 |
内科学 | 65篇 |
神经病学 | 17篇 |
特种医学 | 5篇 |
外科学 | 33篇 |
综合类 | 2篇 |
预防医学 | 29篇 |
眼科学 | 19篇 |
药学 | 33篇 |
肿瘤学 | 11篇 |
出版年
2023年 | 2篇 |
2022年 | 2篇 |
2021年 | 3篇 |
2020年 | 3篇 |
2019年 | 7篇 |
2018年 | 2篇 |
2017年 | 3篇 |
2016年 | 8篇 |
2015年 | 6篇 |
2014年 | 8篇 |
2013年 | 11篇 |
2012年 | 16篇 |
2011年 | 14篇 |
2010年 | 5篇 |
2009年 | 10篇 |
2008年 | 18篇 |
2007年 | 23篇 |
2006年 | 10篇 |
2005年 | 14篇 |
2004年 | 15篇 |
2003年 | 12篇 |
2002年 | 7篇 |
2001年 | 3篇 |
2000年 | 12篇 |
1999年 | 7篇 |
1998年 | 2篇 |
1997年 | 1篇 |
1996年 | 4篇 |
1993年 | 1篇 |
1992年 | 5篇 |
1990年 | 6篇 |
1989年 | 4篇 |
1988年 | 5篇 |
1987年 | 5篇 |
1986年 | 8篇 |
1985年 | 3篇 |
1984年 | 4篇 |
1983年 | 2篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1979年 | 3篇 |
1978年 | 3篇 |
1977年 | 1篇 |
1976年 | 4篇 |
1975年 | 3篇 |
1974年 | 5篇 |
1973年 | 1篇 |
1972年 | 1篇 |
1968年 | 1篇 |
排序方式: 共有297条查询结果,搜索用时 15 毫秒
1.
2.
Objectives
For individuals not on antiretroviral therapy, the risk of heterosexual transmission of HIV appears negligible when blood plasma (BP) viral loads are <1500 HIV‐1 RNA copies/mL. It is not clear whether this observation can be extrapolated to individuals on highly active antiretroviral therapy (HAART). Because of differential tissue penetration, antiretroviral drug concentrations may be sufficient to maintain an undetectable viral load in the BP yet not achieve adequate levels to suppress HIV in the genital tract. Therefore, we wanted to correlate HIV viral loads and drug concentrations in semen plasma (SP) and BP.Methods
Thirty‐three men were included. All were on combination antiretroviral therapy with an undetectable BP viral load for at least 1 year. Blood and semen samples were collected within 2 h of each other and tested for HIV RNA by the NucliSens QT (bioMerieux, St Laurent, QC, Canada) method; drug concentrations were determined by liquid chromatography tandem mass spectrometry.Results
Two of the 33 patients (6.1%) with BP viral loads below detection had time‐matched HIV viral loads in SP ≥700 copies/mL. Both patients were on efavirenz, the SP concentrations of which were ≤10% of the levels in BP and well below the minimal therapeutic drug monitoring target concentration required to suppress HIV.Conclusions
Because, at least in part, of poor drug penetration into the genital tract, an undetectable HIV viral load in the BP does not guarantee an undetectable viral load in semen. In view of this, caution should be taken in concluding that patients on HAART with suppressed viraemia are sexually non‐infectious. 相似文献3.
N. Griffon C. Pilon F. Sautel J. -C. Schwartz P. Sokoloff 《Journal of neural transmission (Vienna, Austria : 1996)》1996,103(10):1163-1175
Summary In NG 108-15 cells expressing the recombinant human D3 receptor, dopamine agonists enhance [3H]thymidine incorporation and decrease cAMP accumulation. In these cells, but not in wild type cells, haloperidol, fluphenazine, and various other antipsychotics inhibited basal [3H]thymidine incorporation in a concentration-dependent manner. In contrast, other dopamine antagonists such as nafadotride or (+)AJ 76, two D3-preferring antagonists, were without effect. The concentration-response curve of haloperidol was shifted to the right in presence of nafadotride, with a potency compatible with its nanomolar apparent affinity as neutral antagonist. Pertussis toxin treatment abolished or markedly reduced the responses to haloperidol or fluphenazine. In contrast, no significant enhancement of cAMP accumulation could be observed, under the influence of haloperidol or eticlopride. These data indicate that some dopamine antagonists behave as inverse agonists, and thus appear to inhibit an agonist-independent activity of the D3 receptor on [3H]thymidine incorporation pathway, but not on the cAMP pathway. 相似文献
4.
5.
Richard S. Surwit Marilyn N. Bradner Cynthia H. Fenton Robert N. Pilon 《Psychophysiology》1978,15(4):320-323
The purpose of the present study was to assess the relationship between lateralization of body image and right versus left vasomotor activity. Fifteen right-handed female patients suffering from idiopathic Raynaud's disease demonstrated a relationship between the extent of right lateralization of body image and bilateral digital skin temperature during a controlled temperature stress test. In addition, subjects showing a reliable right side awareness demonstrated more unilateral vasospastic attacks in their right hand than their left hand white subjects showing no clear right lateralization by body image reported more left hand attacks than right hand attacks. These results were taken as consistent with previous work on the relationship between skin conductance and lateralization of body image. 相似文献
6.
Early studies found that electroencephalographic (EEG) recordings during somnambulistic episodes were characterized by a combination of alpha, theta, and delta frequencies, without evidence of clear wakefulness. Three postarousal EEG patterns associated with slow-wave sleep (SWS) arousals were recently identified in adults with sleepwalking and sleep terrors. The goal of the present study was to evaluate the distribution of these postarousal EEG patterns in 10 somnambulistic patients (three males, seven females, mean age: 25.1, SD: 4.1) evaluated at baseline and following 38 h of sleep deprivation. A total of 44 behavioral arousals were recorded in the laboratory; seven episodes at baseline (five from SWS, two from stage 2 sleep) and 37 episodes during recovery sleep (30 from SWS, seven from stage 2 sleep). There was no significant difference in the distribution of postarousal EEG patterns identified during baseline and recovery sleep. One pattern, comprised of diffuse rhythmic and synchronous delta activity, was preferentially associated with relatively simple behavioral episodes but did not occur during episodes from stage 2 sleep. Overall, delta activity was detected in 48% of the behavioral episodes from SWS and in 22% of those from stage 2. There was no evidence of complete awakening during any of the episodes. The results support the view of somnambulism as a disorder of arousal and suggest that sleepwalkers' atypical arousal reactions can manifest themselves in stage 2 sleep in addition to SWS. 相似文献
7.
1. After 2 years of employee participation, a computerized health risk assessment program managed by occupational health nurses was evaluated to determine whether health risk factor levels had undergone any significant change. 2. Data on 387 hospital employees were examined. Statistically significant reductions in risk factor levels were found for diastolic blood pressure, serum cholesterol, and smoking. The risk factor "weight" remained unchanged from year 1 to year 2 for both groups. 3. These findings suggest that the nursing interventions of focused, written feedback on risk factors, private counseling, and risk reduction education classes may have been important in motivating employees to make significant lifestyle changes. 相似文献
8.
9.
10.
Christiane Gaudreau Sapha Barkati Jean-Michel Leduc Pierre A. Pilon Julie Favreau Sadjia Bekal 《Emerging infectious diseases》2014,20(5):854-856
During 2012–2013 in Montreal, Canada, 4 locally acquired Shigella spp. pulse types with the mph(A) gene and reduced susceptibility to azithromycin were identified from 9 men who have sex with men, 7 of whom were HIV infected. Counseling about prevention of enteric sexually transmitted infections might help slow transmission of these organisms. 相似文献