Epidemiology of atherogenic dyslipoproteinaemias in pubertal children (a prospective study)

The study presents the results of a two-year prospective study of a random representative sample of 772 Moscow pupils, aged 10-13 years. Response rate at entry was 95%, one year later--83%, and 80% two years later. The epidemiological situation regarding various atherogenic dyslipoproteinaemias in pubertal children was studied. The most threatening, i.e., stable dyslipoproteinaemias were detected most often in children with an increased number of risk factors of ischaemic heart disease. Dyslipoproteinaemia stabilization is affected mainly by physical and sexual development of children and their physical activity. These findings can be used for targeted non-medicamentous prevention in pubertal children.     

Effect of micronized fenofibrate (Lipanthyl-200M) on cholesterol synthesis in peripheral blood lymphocytes in hyperlipidemic patients with coronary heart disease

The rate of cholesterol synthesis in peripheral blood lymphocytes and plasma lipid and lipoprotein spectra are studied in patients with isolated hypercholesterolemia and combined hyperlipidemias (IIa and IIb hyperlipidemias according to Frederickson classification).¹⁴C-acetate incorporation into cholesterol in peripheral blood lymphocytes is considerably higher in patients with type IIb hyperlipidemia. Lipanthyl-200M reduces the rate of cholesterol synthesis in lymphocytes of both groups. A direct correlation is established between serum triglyceride level and the rate of cholesterol synthesis. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 5, pp. 569–573, May, 1998     

Dynamics of formation of primary and secondary lipid peroxidation products upon copper-dependent oxidation of low-density lipoproteins isolated from blood serum of patients with ischemic heart disease

The kinetics of copper-induced oxidation of lipids in serum low-density lipoproteins from healthy subjects and patients with ischemic heart disease and documented coronary atherosclerosis is studied. After a 4-h incubation with 40 μM CuSO₄, the oxidizability of patients' lipoproteins is higher, judging from the contents of diene conjugates and oxidation products reacting with thiobarbituric acid. Intergroup differences in the kinetics of the diene conjugate formation are revealed. Statistical analysis shows that in all studied individuals there is no relationship between the oxidizability of low-density lipoproteins and the cholesterol content in lipoproteins and serum. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 7, pp. 32–36, July, 1996     

The clinical and legal characteristics of managing medical documentation in dental implantology

Legislative basis of medical service is developing in Russia and implantation methods of treatment are introduced in practical dentistry; documents regulating legal relations between the patient and doctor (institution) in cases with treatment involving implantation are offered. The proposed clinical examinations can lay the basis for creation of a universal information network which will help develop the references for evaluating the efficacy of types and systems of implants and objectively study the causes of failures in dental implantology.     

Recent advances in diagnosis and management of pulmonary hypertension in chronic lung disease

Pulmonary hypertension with elevated pulmonary vascular resistance is a common cardiovascular complication associated with increased morbidity and mortality in preterm infants with chronic lung disease. Injury to the developing pulmonary circulation results in structural and functional abnormalities of the pulmonary vasculature. Animal studies have demonstrated that disruption of angiogenesis may contribute to the failure of normal alveolarisation in chronic lung disease. Levels of vascular endothelial growth factor in bronchoalveolar lavage fluid are lower in infants with chronic lung disease compared to preterm controls. Supplemental oxygen is commonly used to prevent and treat pulmonary hypertension, although optimal arterial oxygen saturation levels remain uncertain. Other vasodilators such as inhaled nitric oxide appear promising, but as yet have not been evaluated in the form of randomised controlled trials. Further studies are required to investigate the long-term effectiveness of pulmonary vasodilator therapy.     

Relationship of Quality of Life with Disability Grade in Obsessive Compulsive Disorder and Dysthymic Disorder

Background:

There is paucity of information on the relationship of quality of life (QOL) in obsessive compulsive disorder (OCD) and dysthymic disorder (DD) with disability grade in India.

Aim:

To assess the relation of QOL with disability level in OCD and DD.

Materials and Methods:

This hospital based study was conducted in a medical institution in Davanagere, Karnataka, India. Data was collected by using Diagnostic and Statistical Manual IV Text Revision (DSM IV TR) criteria, WHO QOL BREF and IDEAS. Relationship between disability grade and QOL was assessed by independent sample t test.

Results:

Mild disabled OCD patients had a significantly better QOL in the Q1 domain i.e. perception on quality of life as compared to moderately disabled patients (P < 0.05), while in other domains of QOL, there was no statistically significant difference (P > 0.05). But, QOL score in physical domain showed significant difference across disability grades (56.00, SD = 6.89; 48.50, SD = 12.28) in DD, but not in other domains.

Conclusion:

Perception of QOL is better in those with mild disability in OCD, but in DD, physical domain of QOL score is more in mild disability compared to moderate disability.     

Antimicrobial Activity of Lyophilized Aqueous Extract from Caragana Jubata (Pall.) Poir.

Pharmaceutical Chemistry Journal - The flavonoid profile of the lyophilized aqueous extract of Caragana jubata shoots was established based on previous studies. The antimicrobial activity of the...     

Changes in the indices of plasma lipoprotein and apolipoprotein spectra in patients with myocardial infarct and unstable stenocardia over the course of a year's observation

Over the period of one year the authors examined the changes in the parameters of the plasma spectrum of lipoproteins and apolipoproteins in 46 patients with acute macrofocal myocardial infarction and 35 patients with labile angina. In six cases variations in these parameters were studied in the course of unstable angina and in the post-infarction period. It was established that myocardial infarction induced specific alterations in the plasma lipoprotein system not only in the immediate post-infarction period but also at more long-term periods. Myocardial infarction causes deep and prolonged disorders in the apolipoprotein system which may contribute to the progression of atherosclerotic damage to the coronary arteries.