全文获取类型
收费全文 | 1204篇 |
免费 | 61篇 |
国内免费 | 47篇 |
专业分类
耳鼻咽喉 | 36篇 |
儿科学 | 73篇 |
妇产科学 | 37篇 |
基础医学 | 131篇 |
口腔科学 | 27篇 |
临床医学 | 122篇 |
内科学 | 178篇 |
皮肤病学 | 28篇 |
神经病学 | 45篇 |
特种医学 | 189篇 |
外科学 | 130篇 |
综合类 | 30篇 |
预防医学 | 73篇 |
眼科学 | 7篇 |
药学 | 75篇 |
中国医学 | 2篇 |
肿瘤学 | 129篇 |
出版年
2021年 | 9篇 |
2020年 | 5篇 |
2019年 | 8篇 |
2018年 | 7篇 |
2017年 | 8篇 |
2016年 | 12篇 |
2015年 | 36篇 |
2014年 | 42篇 |
2013年 | 86篇 |
2012年 | 42篇 |
2011年 | 34篇 |
2010年 | 38篇 |
2009年 | 35篇 |
2008年 | 37篇 |
2007年 | 65篇 |
2006年 | 27篇 |
2005年 | 37篇 |
2004年 | 42篇 |
2003年 | 25篇 |
2002年 | 47篇 |
2001年 | 27篇 |
2000年 | 28篇 |
1999年 | 24篇 |
1998年 | 23篇 |
1997年 | 27篇 |
1996年 | 19篇 |
1995年 | 32篇 |
1994年 | 20篇 |
1993年 | 14篇 |
1992年 | 34篇 |
1991年 | 31篇 |
1990年 | 26篇 |
1989年 | 35篇 |
1988年 | 25篇 |
1987年 | 28篇 |
1986年 | 21篇 |
1985年 | 26篇 |
1984年 | 20篇 |
1983年 | 22篇 |
1982年 | 21篇 |
1981年 | 14篇 |
1980年 | 20篇 |
1979年 | 16篇 |
1978年 | 8篇 |
1976年 | 14篇 |
1975年 | 5篇 |
1973年 | 5篇 |
1971年 | 9篇 |
1948年 | 4篇 |
1947年 | 6篇 |
排序方式: 共有1312条查询结果,搜索用时 31 毫秒
1.
Ann G Schwartz Geoffrey M Prysak Valerie Murphy Fulvio Lonardo Harvey Pass Jan Schwartz Sam Brooks 《Clinical cancer research》2005,11(20):7280-7287
PURPOSE: A role for estrogens in determining lung cancer risk and prognosis is suggested by reported sex differences in susceptibility and survival. Archival lung tissue was evaluated for the presence of nuclear estrogen receptor (ER)-alpha and ER-beta and the relationship between ER status, subject characteristics, and survival. EXPERIMENTAL DESIGN: Paraffin-embedded lung tumor samples were obtained from 214 women and 64 men from two population-based, case-control studies as were 10 normal lung autopsy samples from patients without cancer. Nuclear ER-alpha and ER-beta expression was determined by immunohistochemistry. Logistic regression was used to identify factors associated with ER positivity and Cox proportional hazards models were used to measure survival differences by ER status. RESULTS: Neither tumor (0 of 94) nor normal (0 of 10) lung tissue stained positive for ER-alpha. Nuclear ER-beta positivity was present in 61% of tumor tissue samples (170 of 278; 70.3% in men and 58.3% in women) and 20% of normal tissue samples (2 of 10; P = 0.01). In multivariate analyses, females were 46% less likely to have ER-beta-positive tumors than males (odds ratio, 0.54; 95% confidence interval, 0.27-1.08). This relationship was stronger and statistically significant in adenocarcinomas (odds ratio, 0.40; 95% confidence interval, 0.18-0.89). Women with ER-beta-positive tumors had a nonsignificant 73% (P = 0.1) increase in mortality, whereas men with ER-beta-positive tumors had a significant 55% (P = 0.04) reduction in mortality compared with those with ER-beta-negative tumors. CONCLUSIONS: This study suggests differential expression by sex and influence on survival in men of nuclear ER-beta in lung cancer, particularly in adenocarcinomas. 相似文献
2.
氟喹诺酮类药物不良反应168例分析 总被引:12,自引:0,他引:12
0 引言 随着氟喹诺酮类药物在临床的广泛应用,有关其应用所致不良反应的报道也日趋增多,我们通过对1990/2003年我院氟喹诺酮类药物不良反应情况报告如下,供临床参考。 相似文献
3.
Dr. Barry Pass John E. Aldrich Patricia L. Scallion 《Calcified tissue international》1990,46(3):166-168
Summary The ESR spectra produced in irradiated dentin have been studied over a range of incident radiation energies from 50 kVp to
25 MVp. The behavior of the dentin ESR signal strength is similar to that of enamel as a function of the energy of the incident
radiation. The magnitude of the dentin ESR signals are, however, up to 10 times smaller than the signals of dental enamel
for a given radiation energy. The possible contributions of radiation interaction coefficients, chemical structure, and crystallite
size to the differences in ESR spectra are discussed. 相似文献
4.
Factors influencing women to undergo screening mammography 总被引:2,自引:0,他引:2
5.
6.
H W Pogrebniak M J Merino S M Hahn J B Mitchell H I Pass 《Surgery》1992,112(2):130-9; discussion 138-9
7.
Monoclonal antibody K1 reacts with epithelial mesothelioma but not with lung adenocarcinoma. 总被引:8,自引:0,他引:8
K Chang L H Pai H Pass H W Pogrebniak M S Tsao I Pastan M C Willingham 《The American journal of surgical pathology》1992,16(3):259-268
Immunoperoxidase histochemical staining of cryostat sections from human tumor tissues revealed that a murine monoclonal antibody (MAb), K1, can distinguish epithelial mesotheliomas from lung adenocarcinomas. All of 15 epithelial-type mesotheliomas and all four mixed type mesothelioma samples, but none of 23 lung adenocarcinomas with different degrees of histologic differentiation demonstrated reactivity with antibody K1. Of the cell populations in each mesothelioma tested, 80% to 100% showed strong and homogeneous staining with MAb K1. Immunofluorescence analysis of live cultured cells from an epithelioid mesothelioma (H-meso) and several lung carcinoma cell lines as well as a pleural effusion of a patient with mesothelioma also showed selective reactivity of K1 with the mesothelioma cells. These data indicate that K1 can be useful as a mesothelial cell marker for the differential pathological diagnosis of the epithelial form of mesothelioma; K1 may also be useful in the study of the pathogenesis, immunodiagnosis, and immunotherapy of epithelial-type and mixed-type human malignant mesothelioma. 相似文献
8.
Dr. Harvey I. Pass MD Karen Kranda RN Barbara K. Temeck MD Irwin Feuerstein MD Seth M. Steinberg PhD 《Annals of surgical oncology》1997,4(3):215-222
Background: We analyzed morbidity and mortality, sites of recurrence, and possible prognostic factors in 95 (78 male, 17 female) patients
with MPM on phase I–III trials since 1990. A debulking resection to a requisite, residual tumor thickness of ≤ 5 mm was required
for inclusion.
Methods: Preoperative tumor volumes were determined by three-dimensional reconstruction of chest computerized tomograms. Pleurectomy
(n=39) or extrapleural pneumonectomy (EPP; n=39) was performed. Seventeen patients could not be debulked. Preoperative EPP
platelet counts (404,000) and mean tumor volume (491 cm3) were greater than that seen for pleurectomy (344,000, 114 cm3).
Results: Median survival for all patients was 11.2 months, with that for pleurectomy 14.5 months, that for EPP 9.4 months, and that
for unresectable patients 5.0 months. Arrhythmia (n=14; 15%) was the most common complication, and there were two deaths related
to surgery (2.0%). Tumor volume of >100 ml, biphasic histology, male sex, and elevated platelet count were associated with
decreased survival (p<0.05). Both EPP and pleurectomy had equivalent recurrence rates (27 of 39 [69%] and 31 of 39 [79%],
respectively); however, 17 of 27 EPP recurrences as opposed to 28 of 31 pleurectomy recurrences were locoregional (p2=0.013).
Conclusions: Debulking resections for MPM can be performed with low operative mortality. Size and platelet count are important preoperative
prognostic parameters for MPM. Patients with poor prognostic indicators should probably enter nonsurgical, innovative trials
where toxicity or response to therapy can be evaluated.
Presented at the 49th Annual Cancer Symposium of The Society of Surgical Oncology, Atlanta, Georgia, March 21–24, 1996. 相似文献
9.
Friction, capacitance and transepidermal water loss (TEWL) in dry atopic and normal skin 总被引:2,自引:0,他引:2
MARIE LODÉN HÅKAN OLSSON TONY AXÉLL YLVA WERNER LINDE† 《The British journal of dermatology》1992,126(2):137-141
The biophysical properties of non-eczematous skin at three locations in atopics and non-atopics were characterized using non-invasive physical methods. Skin friction was measured with a newly developed sliding friction instrument, the degree of hydration with a capacitance meter (Corneometer CM 820), and the transepidermal water loss (TEWL) was determined using an Evaporimeter EP1. The areas examined (dorsum of the hand, volar forearm and lower back) showed lower values of friction and capacitance in the atopic patients than did corresponding sites in the normal controls. In most areas a significant correlation between friction and capacitance was found. The TEWL was increased in atopic skin, but TEWL seems to correlate neither to friction nor to capacitance. 相似文献
10.
Rechtsanwalt Dr. iur. Matthias Dann LL.M. 《MedR Medizinrecht》2007,25(11):638-643
Ohne Zusammenfassung 相似文献